公开(公告)号：US20220196647A1

公开(公告)日：2022-06-23

申请号：US17690177

申请日：2022-03-09

Applicant: FUJIFILM Corporation

Inventor： Yoshihiro ABURAYA ,  Naoyuki NISHIKAWA ,  Junichi KATADA ,  Atsuhiko WADA ,  Dai UJIHARA

IPC: G01N33/543 ,  G01N1/40

Abstract: An immunochromatography including steps of mixing an antigen-containable specimen and modified magnetic particles, which are magnetic particles modified with a monoclonal antibody X; collecting the magnetic particles from the mixture using magnetism; dissociating the modified magnetic particles to obtain an antigen-containing solution; neutralizing the antigen-containing solution to obtaina neutralized antigen-containing solution; spreading gold particle composite bodies on an insoluble carrier having a reaction site at which a monoclonal antibody Z has been immobilized, wherein the gold particle composite body is a composite body of the antigen and a modified gold particle which is a gold particle modified with a monoclonal antibody Y; capturing the gold particle composite bodies at the reaction site; and silver-amplifying the gold particle composite body, in which the antibody X and the antibody Y are different from each other, and the antibody X and the antibody Z are different from each other.

公开(公告)号：US20220011303A1

公开(公告)日：2022-01-13

申请号：US17487534

申请日：2021-09-28

Applicant: FUJIFILM Corporation

Inventor： Yoshihiro ABURAYA ,  Naoyuki NISHIKAWA ,  Junichi KATADA ,  Dai UJIHARA ,  Atsuhiko WADA

IPC: G01N33/543

Abstract: An object of the present invention is to provide immunochromatography exhibiting excellent magnetic detection sensitivity. The immunochromatography of the present invention is immunochromatography including a mixing step of mixing a specimen that is capable of containing a test substance with a modified composite particle that is a composite particle modified with a first binding substance that is capable of binding to the test substance, to obtain a complex of the test substance in the specimen and the modified composite particle; a developing step of developing the complex on an insoluble carrier having a reaction site at which a second binding substance capable of binding to the test substance is immobilized; a capturing step of capturing the complex at the reaction site of the insoluble carrier; and a silver amplification step of silver-amplifying the complex captured in the capturing step, where the composite particle is a composite particle of a magnetic particle and a gold particle carried on a surface of the magnetic particle.

公开(公告)号：US20210263030A1

公开(公告)日：2021-08-26

申请号：US17187264

申请日：2021-02-26

Applicant: FUJIFILM Corporation

Inventor： Tomoya OHARA ,  Natsuki OYABU ,  Atsuhiko WADA ,  Junichi KATADA ,  Dai UJIHARA

IPC: G01N33/569 ,  G01N33/548 ,  C07K16/12

Abstract: An object of the present invention is to provide an immunochromatographic kit and a method, which are capable of detecting Mycobacterium tuberculosis with high-sensitivity and specificity. According to the present invention, an immunochromatographic kit for detecting Mycobacterium tuberculosis is provided, the kit including: a label substance modified with a first antibody against lipoarabinomannan; a porous carrier having a reaction site holding a second antibody against lipoarabinomannan; a compound containing silver; and a reducing agent reducing silver ions, in which at least one of the first antibody or the second antibody is a monoclonal antibody.

公开(公告)号：US20210208138A1

公开(公告)日：2021-07-08

申请号：US17205649

申请日：2021-03-18

Applicant: FUJIFILM Corporation

Inventor： Yoshihiro ABURAYA ,  Naoyuki NISHIKAWA ,  Junichi KATADA ,  Hiroyuki CHIKU ,  Ayumi ERA

IPC: G01N33/543 ,  C01G49/08 ,  G01N33/531 ,  G01N33/553

Abstract: An object of the present invention is to provide a composite particle for an immunochromatography which has excellent spreadability, a method for manufacturing the same, and an immunochromatography using the composite particle for an immunochromatography. A composite particle for an immunochromatography of the present invention is a composite particle for an immunochromatography in which magnetic particles having an average particle size of 500 nm or less and gold particles having an average particle size of 500 nm or less are bound via an organic substance.

公开(公告)号：US20190224693A1

公开(公告)日：2019-07-25

申请号：US16367807

申请日：2019-03-28

Applicant: FUJIFILM Corporation

Inventor： Atsuhiko WADA ,  Keiji SHIGESADA ,  Junichi KATADA

IPC: B05B1/10 ,  B01L3/02 ,  G01N33/543 ,  G01N1/10

Abstract: A nozzle includes a mounting opening that is to be connected to an opening portion of a container, an outlet that jets liquid stored in the container, a side face that connects the mounting opening to the outlet, and a liquid storage portion that stores a part of the liquid stored in the container in the nozzle without jetting a part of the liquid from the outlet in a case where the liquid is to be jetted from the dispensing container, that is, in a case where the outlet faces downward in the direction of gravity.