IMMUNOCHROMATOGRAPHY
    1.
    发明申请

    公开(公告)号:US20220334111A1

    公开(公告)日:2022-10-20

    申请号:US17852053

    申请日:2022-06-28

    Abstract: An immunochromatography includes steps of mixing a specimen capable of containing an antigen and a modified particle, which is a particle modified with a substance having a specific affinity to the antigen, to obtain a mixture containing particle composite bodies; sedimenting the particle composite bodies in the mixture using a centrifuge; dissociating the sedimented particle composite bodies into the particles and the antigen by mixing the sedimented particle composite bodies with a dissociation solution, recovering an antigen-concentrated solution by sedimenting the dissociated particles using a centrifuge; neutralizing the antigen-concentrated solution using a neutralization solution; spreading particle composite bodies for labeling on an insoluble carrier having a reaction site, in a state where the particle composite bodies for labeling, which are composite bodies of the antigen in the neutralized antigen-concentrated solution and a modified particle for labeling, are formed; and capturing the particle composite bodies for labeling at the reaction site.

    IMMUNOLOGICAL TEST METHOD
    2.
    发明申请

    公开(公告)号:US20220341926A1

    公开(公告)日:2022-10-27

    申请号:US17859292

    申请日:2022-07-07

    Abstract: An immunological test method includes a concentration step of mixing a solution capable of containing an antigen, a superabsorbent polymer, and a labeled antibody against the antigen, to obtain a concentrated and mixed solution which is a concentrated mixed solution containing composite bodies of the antigen and the labeled antibody and a detection step of detecting the composite bodies in the concentrated and mixed solution using an antigen-antibody reaction, in which a swelling ratio of the superabsorbent polymer is more than 0.2 g/g and less than 800 g/g.

    METHOD FOR IMMOBILIZATION, PHYSIOLOGICALLY ACTIVE SUBSTANCE-IMMOBILIZED CARRIER, CARRIER FOR IMMOBILIZATION, CARRIER, AND PROCESS FOR PRODUCING CARRIER
    3.
    发明申请
    METHOD FOR IMMOBILIZATION, PHYSIOLOGICALLY ACTIVE SUBSTANCE-IMMOBILIZED CARRIER, CARRIER FOR IMMOBILIZATION, CARRIER, AND PROCESS FOR PRODUCING CARRIER 有权
    用于固定的化学方法,生理活性物质固定载体,用于固定载体,载体和用于生产载体的方法

    公开(公告)号:US20130150562A1

    公开(公告)日:2013-06-13

    申请号:US13759463

    申请日:2013-02-05

    CPC classification number: C07F7/1804 G01N33/54353 G01N33/54393 Y10T428/2991

    Abstract: An immobilization method for immobilizing a physiologically active substance on a solid phase carrier, the method including: bringing the solid phase carrier into contact with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I); and carrying out a process of binding of the physiologically active substance to the acid anhydride functional group while maintaining the solid phase carrier after the contact at a temperature within the range of 0° C. to 60° C.; a physiologically active substance-immobilized carrier, and a carrier for immobilization are provided. Further, a carrier including a porous material treated with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I), a blocking agent that is immobilized to the porous material; and a method for producing it is provided.

    Abstract translation: 一种用于将生理活性物质固定在固相载体上的固定方法,所述方法包括:使固相载体与由下式(I)表示的含酸酐官能团的硅烷偶联剂接触; 并且在0℃至60℃的范围内的温度下,将生理活性物质与酸酐官能团结合,同时保持接触后的固相载体; 提供生理活性物质固定化载体和用于固定的载体。 此外,包括用下述通式(I)表示的含酸酐官能团的硅烷偶联剂处理的多孔材料的载体,固定在多孔材料上的封端剂; 并提供其制造方法。

    IMMUNOCHROMATOGRAPHIC DEVICE
    4.
    发明申请

    公开(公告)号:US20130137190A1

    公开(公告)日:2013-05-30

    申请号:US13749148

    申请日:2013-01-24

    Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.

    CONCENTRATION DEVICE, SAMPLE SOLUTION CONCENTRATION METHOD, SAMPLE SOLUTION EXAMINATION METHOD, AND EXAMINATION KIT

    公开(公告)号:US20230251248A1

    公开(公告)日:2023-08-10

    申请号:US18182227

    申请日:2023-03-10

    CPC classification number: G01N33/543 B01D69/02 B01D67/0079

    Abstract: There are provided a concentration device that makes it possible to concentrate a sample solution in a short time, a sample solution concentration method using the concentration device to concentrate a sample solution, a sample solution concentration method using the sample solution examination method, and an examination kit including the concentration device and the detection device. The concentration device for concentrating a sample solution which is an aqueous solution containing a high-molecular-weight molecule contained in a biological fluid is a concentration device including a first container containing a super absorbent polymer and a second container, in which a part of the first container is constituted of a discharge unit consisting of a porous membrane having a hole diameter of 0.05 μm or more and 10 μm or less, the super absorbent polymer absorbs a solution contained in the sample solution injected into the first container to generate, in the first container, a sample solution concentrated solution which is a concentrated solution of the sample solution, and the second container recovers the sample solution concentrated solution discharged from the discharge unit.

    IMMUNOLOGICAL TEST METHOD AND CONCENTRATION JIG

    公开(公告)号:US20220196643A1

    公开(公告)日:2022-06-23

    申请号:US17690101

    申请日:2022-03-09

    Abstract: The immunological test method includes a concentration step of concentrating an antigen-containable solution by mixing the antigen-containable solution with a superabsorbent polymer to obtain an antigen-concentrated solution, and a detection step of detecting an antigen in the antigen-concentrated solution using an antigen-antibody reaction, in which a swelling ratio of the superabsorbent polymer is more than 0.2 g/g and less than 800 g/g, and an antibody that is used in the antigen-antibody reaction is a monoclonal antibody.

    IMMUNOCHROMATOGRAPHY
    8.
    发明申请

    公开(公告)号:US20220196523A1

    公开(公告)日:2022-06-23

    申请号:US17690854

    申请日:2022-03-09

    Abstract: An immunochromatography including steps of mixing an antigen-containable specimen and modified magnetic particles, which are magnetic particles modified with a substance having a specific affinity to the antigen; collecting the magnetic particles using magnetism; dissociating the modified magnetic particles to obtain an antigen-concentrated solution by mixing the collected magnetic particles with a dissociation solution, an amount of which is smaller than the antigen-containable specimen; obtaining a neutralized antigen-concentrated solution; spreading gold particle composite bodies on an insoluble carrier having a reaction site at which a second binding substance has been immobilized, in a state where the gold particle composite bodies which are composite bodies of an antigen in the neutralized antigen-concentrated solution and modified gold particles which are gold particles modified with a first binding substance are formed; capturing the gold particle composite bodies at the reaction site; and silver-amplifying the gold particle composite body.

    IMMUNOCHROMATOGRAPHY
    10.
    发明申请

    公开(公告)号:US20220326227A1

    公开(公告)日:2022-10-13

    申请号:US17851215

    申请日:2022-06-28

    Abstract: An immunochromatography includes a concentration step of concentrating a solution capable of containing an antigen by ultrafiltration to obtain an antigen-concentrated solution; a spreading step of spreading particle composite bodies on an insoluble carrier having a reaction site at which a second binding substance capable of binding to an antigen in the antigen-concentrated solution has been immobilized, in a state where the particle composite bodies which are composite bodies of the antigen and a modified particle which is a particle modified with a first binding substance capable of binding to the antigen are formed; a capturing step of capturing the particle composite bodies at the reaction site of the insoluble carrier; and an amplification step of amplifying information of the particle composite bodies captured in the capturing step.

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