公开(公告)号：US20190136301A1

公开(公告)日：2019-05-09

申请号：US16245301

申请日：2019-01-11

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Doron Lipson ,  Geoffrey Alan Otto ,  Alexander Nevin Parker ,  Philip James Stephens ,  Sean R. Downing ,  Mirna Jarosz ,  Mikhail G. Shapiro ,  Roman Yelensky

IPC: C12Q1/6827 ,  C12Q1/6874

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

公开(公告)号：US20190032118A1

公开(公告)日：2019-01-31

申请号：US15897824

申请日：2018-02-15

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Doron Lipson ,  Geoffrey Alan Otto ,  Alexander N. Parker ,  Philip James Stephens ,  Sean R. Downing ,  Mirna Jarosz ,  Mikhail G. Shapiro ,  Roman Yelensky

IPC: C12Q1/6827 ,  C12Q1/6874

Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

公开(公告)号：US20140243390A1

公开(公告)日：2014-08-28

申请号：US14187280

申请日：2014-02-23

Applicant: FOUNDATION MEDICINE, INC.

Inventor： Sean R. Downing ,  Matthew J. Hawryluk ,  Doron Lipson ,  Alexander N. Parker ,  Philip James Stephens

IPC: C12N15/113 ,  A61K31/47 ,  A61K31/513 ,  A61K31/517 ,  A61K31/444 ,  A61K31/4412 ,  A61K31/404

CPC classification number: A61K31/517 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/444 ,  A61K31/47 ,  A61K31/513 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/14 ,  C12N15/1135 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Novel RET fusion molecules and uses are disclosed.

Abstract translation: 公开了新型RET融合分子和用途。