公开(公告)号：US20200063218A1

公开(公告)日：2020-02-27

申请号：US16672224

申请日：2019-11-01

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/686 ,  C12Q1/6851

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US10508313B2

公开(公告)日：2019-12-17

申请号：US15816036

申请日：2017-11-17

Applicant: GEN-PROBE INCORPORATED

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q1/6851

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US11268159B2

公开(公告)日：2022-03-08

申请号：US15618598

申请日：2017-06-09

Applicant: GEN-PROBE INCORPORATED

Inventor： Kui Gao ,  Jeffrey M. Linnen ,  Kurt C. Norton ,  Patricia C. Gordon ,  Dat Do ,  Tan N. Le

IPC: C12Q1/70

Abstract: Nucleic acid oligomers specific for human parvovirus genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus genotypes 1, 2 and 3 nucleic acid in biological specimens is disclosed. Compositions for amplifying and detecting the presence of human parvovirus genotypes 1, 2 and 3 genomic DNA in human biological specimens are disclosed.

公开(公告)号：US11162091B2

公开(公告)日：2021-11-02

申请号：US16094070

申请日：2017-04-26

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jijumon Chelliserry ,  Jeffrey Linnen

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/70

Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.

公开(公告)号：US20180334727A1

公开(公告)日：2018-11-22

申请号：US16019829

申请日：2018-06-27

Applicant: Gen-Probe Incorporated

Inventor： Jijumon Chelliserry ,  Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/6893 ,  C12N1/06 ,  G01N33/48

Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.

公开(公告)号：US10047406B2

公开(公告)日：2018-08-14

申请号：US14460180

申请日：2014-08-14

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Edgar O. Ong ,  Jennifer Cole ,  Jeffrey M. Linnen

IPC: C07H21/04 ,  C12Q1/70

CPC classification number: C12Q1/707

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

公开(公告)号：US20250154612A1

公开(公告)日：2025-05-15

申请号：US19025006

申请日：2025-01-16

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/6851 ,  C12Q1/686

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US20220074003A1

公开(公告)日：2022-03-10

申请号：US17529876

申请日：2021-11-18

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/686 ,  C12Q1/6851

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US11220719B2

公开(公告)日：2022-01-11

申请号：US16672224

申请日：2019-11-01

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q1/6851

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US20220002707A1

公开(公告)日：2022-01-06

申请号：US17485599

申请日：2021-09-27

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jijumon Chelliserry ,  Jeffrey Linnen

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/70

Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.