公开(公告)号：US11821046B2

公开(公告)日：2023-11-21

申请号：US17032310

申请日：2020-09-25

Applicant: GEN-PROBE INCORPORATED

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Zika virus nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

公开(公告)号：US10689713B2

公开(公告)日：2020-06-23

申请号：US16019829

申请日：2018-06-27

Applicant: Gen-Probe Incorporated

Inventor： Jijumon Chelliserry ,  Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/68 ,  C12Q1/6893 ,  C12N1/06 ,  G01N33/48 ,  C12Q1/6806

Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.

公开(公告)号：US20250154612A1

公开(公告)日：2025-05-15

申请号：US19025006

申请日：2025-01-16

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/6851 ,  C12Q1/686

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US20220074003A1

公开(公告)日：2022-03-10

申请号：US17529876

申请日：2021-11-18

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/686 ,  C12Q1/6851

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US11220719B2

公开(公告)日：2022-01-11

申请号：US16672224

申请日：2019-11-01

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/70 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q1/6851

Abstract: This disclosure provides oligomers, compositions, and kits for detecting and quantifying Hepatitis B virus (HBV), including different genotypes and variants thereof, and related methods and uses. In some embodiments, oligomers target the P and/or S open reading frames of HBV and are configured to provide substantially equivalent quantification of different genotypes and variants of HBV.

公开(公告)号：US10745767B2

公开(公告)日：2020-08-18

申请号：US15879921

申请日：2018-01-25

Applicant: GEN-PROBE INCORPORATED

Inventor： Jeffrey M. Linnen ,  Daniel P. Kolk ,  Janel M. Dockter ,  Damon K. Getman ,  Tadashi Yoshimura ,  Martha K. Ho-Sing-Loy ,  Reinhold B. Pollner ,  Leslie A. Stringfellow

IPC: C12Q1/68 ,  C12Q1/70

Abstract: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.

公开(公告)号：US20180334734A1

公开(公告)日：2018-11-22

申请号：US16015539

申请日：2018-06-22

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Edgar O. Ong ,  Jennifer Cole ,  Jeffrey M. Linnen

IPC: C12Q1/70

CPC classification number: C12Q1/707

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

公开(公告)号：US10093989B2

公开(公告)日：2018-10-09

申请号：US14918131

申请日：2015-10-20

Applicant: Gen-Probe Incorporated

Inventor： Jijumon Chelliserry ,  Kui Gao ,  Jeffrey M. Linnen

IPC: C12Q1/68 ,  C12Q1/6893 ,  C12N1/06 ,  G01N33/48

Abstract: The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing.

公开(公告)号：US10053742B2

公开(公告)日：2018-08-21

申请号：US14911667

申请日：2014-08-14

Applicant: GEN-PROBE INCORPORATED

Inventor： Kui Gao ,  Edgar O. Ong ,  Jennifer Cole ,  Jeffrey M. Linnen

IPC: C07H21/04 ,  C12Q1/70

CPC classification number: C12Q1/707

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.

公开(公告)号：US11572596B2

公开(公告)日：2023-02-07

申请号：US17012946

申请日：2020-09-04

Applicant: Gen-Probe Incorporated

Inventor： Kui Gao ,  Edgar O. Ong ,  Jennifer Cole ,  Jeffrey M. Linnen

IPC: C12Q1/70

Abstract: Disclosed are nucleic acid oligomers, including amplification oligomers, capture probes, and detection probes, for detection of Hepatitis E Virus (HEV) nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding reaction mixtures and kits.