公开(公告)号：US20180201693A1

公开(公告)日：2018-07-19

申请号：US15742803

申请日：2016-07-01

Applicant: GENMAB A/S

Inventor： Richard G. HIBBERT ,  Aran F. LABRIJN ,  Arnout F. GERRITSEN ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/46

CPC classification number: C07K16/468 ,  C07K16/2863 ,  C07K16/2887 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2317/94

Abstract: Bispecific and multispecific antibodies having differentially modified light chains, that allows for isolation of the bispecific or multispecific antibodies based on a differential affinity towards an affinity reagent.

公开(公告)号：US20170369594A1

公开(公告)日：2017-12-28

申请号：US15599395

申请日：2017-05-18

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Bart DE GOEIJ ,  Aran Frank LABRIJN ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/46 ,  A61K39/395 ,  C07K1/113 ,  C07K16/10 ,  C07K16/28 ,  A61K47/68 ,  C07K16/32 ,  A61K39/00

Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.

公开(公告)号：US20170327597A1

公开(公告)日：2017-11-16

申请号：US15536143

申请日：2015-12-18

Applicant: GENMAB A/S

Inventor： Aran F. LABRIJN ,  Joyce I. MEESTERS ,  Janine SCHUURMAN ,  Paul PARREN ,  Anthony ARMSTRONG ,  Matthew BUNCE ,  Mark CHIU ,  Thomas NESSPOR ,  Adam ZWOLAK

IPC: C07K16/46 ,  C07K16/40 ,  A61K49/00 ,  C07K16/28

CPC classification number: C07K16/462 ,  A61K49/0008 ,  C07K16/00 ,  C07K16/2809 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/64 ,  C07K2317/73

Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.

公开(公告)号：US20170240640A1

公开(公告)日：2017-08-24

申请号：US15420824

申请日：2017-01-31

Applicant: GENMAB A/S

Inventor： Janine SCHUURMAN ,  Catharina Emanuele Gerarda HAVENITH ,  Paul PARREN ,  Jan G. J. VAN DE WINKEL ,  Denise Leah WILLIAMS ,  Jørgen PETERSEN ,  Ole BAADSGAARD

IPC: C07K16/28 ,  G01N33/569 ,  C07K16/42 ,  G01N33/68 ,  A61K45/06 ,  A61K39/395

Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US20150259424A1

公开(公告)日：2015-09-17

申请号：US14592558

申请日：2015-01-08

Applicant: GENMAB A/S

Inventor： Janine SCHUURMAN ,  Catharina Emanuele Gerarda HAVENITH ,  Paul PARREN ,  Jan G.J. VAN DE WINKEL ,  Denise Leah WILLIAMS ,  Jørgen PETERSEN ,  Ole BAADSGAARD

IPC: C07K16/28 ,  A61K45/06 ,  A61N5/06 ,  C07K16/46 ,  G01N33/574 ,  A61K39/395 ,  C07K16/42

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61N5/062 ,  C07K16/4258 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/56966 ,  G01N33/57492 ,  G01N33/6854 ,  G01N33/6869 ,  G01N2333/70596 ,  G01N2333/715 ,  G01N2333/7155

Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

Abstract translation: 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。

公开(公告)号：US20240209117A1

公开(公告)日：2024-06-27

申请号：US18507869

申请日：2023-11-13

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Edwald T. J. VAN DER BREMER ,  Joost J. NEIJSSEN ,  Patrick VAN BERKEL ,  Bart DE GOEIJ ,  Tom VINK ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/46 ,  A61K39/00 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  G01N33/68

CPC classification number: C07K16/468 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/40 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins

公开(公告)号：US20230295335A1

公开(公告)日：2023-09-21

申请号：US18184120

申请日：2023-03-15

Applicant: Genmab A/S ,  BioNTech SE

Inventor： Andreea IOAN ,  Esther Cornelia Wilhelmina BREIJ ,  Lars GUELEN ,  David P.E. SATIJN ,  Ugur SAHIN ,  Alexander MUIK ,  Kristina SCHÖDEL ,  Sina FELLERMEIER-KOPF ,  Bart-Jan DE KREUK ,  Richard HIBBERT ,  Janine SCHUURMAN ,  Aran Frank LABRIJN

IPC: C07K16/30 ,  C07K16/28

CPC classification number: C07K16/30 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/92

Abstract: The present invention provides a binding agent that binds to EpCAM and to CD137 which is useful to treat or prevent a tumor or cancer, or to prevent progression of a tumor or cancer.

公开(公告)号：US20210061919A1

公开(公告)日：2021-03-04

申请号：US16947021

申请日：2020-07-15

Applicant: GENMAB A/S

Inventor： Jan VAN DE WINKEL ,  Tom VINK ,  Janine SCHUURMAN ,  Paul PARREN ,  Rob AALBERSE ,  Marijn VAN DER NEUT KOLFSCHOTEN

IPC: C07K16/28 ,  A61K51/10 ,  C07K16/00 ,  A61K47/68 ,  C07K16/16 ,  C07K16/18

Abstract: The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

公开(公告)号：US20200262932A1

公开(公告)日：2020-08-20

申请号：US16777053

申请日：2020-01-30

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Ewald T. J. VAN DEN BREMER ,  Joost J. NEIJSSEN ,  Patrick VAN BERKEL ,  Bart DE GOEIJ ,  Tom VINK ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/46 ,  G01N33/68 ,  C07K16/40 ,  C07K16/32 ,  C07K16/28 ,  C07K16/10

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins

公开(公告)号：US20190284278A1

公开(公告)日：2019-09-19

申请号：US15744317

申请日：2016-07-14

Applicant: GENMAB A/S

Inventor： Rik RADEMAKER ,  Isil ALTINTAS ,  Patrick ENGELBERTS ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/28 ,  C07K16/32

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.