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公开(公告)号：US20220213177A1
公开(公告)日：2022-07-07
申请号：US17564962
申请日：2021-12-29
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Kurt SWANSON , Philip R. DORMITZER
IPC: C07K16/10 , A61K39/155 , A61K39/12 , C07K14/005
Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
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