公开(公告)号：US20250042951A1

公开(公告)日：2025-02-06

申请号：US18895059

申请日：2024-09-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Andrea CARFI

IPC: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US20230357371A1

公开(公告)日：2023-11-09

申请号：US18323192

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230303669A1

公开(公告)日：2023-09-28

申请号：US18323215

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230287056A1

公开(公告)日：2023-09-14

申请号：US18308583

申请日：2023-04-27

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Andrea CARFI

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/155

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/53

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US20220372115A1

公开(公告)日：2022-11-24

申请号：US17848176

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20240239845A1

公开(公告)日：2024-07-18

申请号：US18596426

申请日：2024-03-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Andrea CARFI

IPC: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/53 ,  C07K2319/735 ,  C12N2760/18522 ,  C12N2760/18534

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US20230357369A1

公开(公告)日：2023-11-09

申请号：US18323177

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  C07K16/10

CPC classification number: C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20210269489A1

公开(公告)日：2021-09-02

申请号：US17314649

申请日：2021-05-07

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Andrea CARFI

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/155

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US20180237476A1

公开(公告)日：2018-08-23

申请号：US15789074

申请日：2017-10-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Kurt SWANSON ,  Andrea CARFI

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/155

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/53 ,  C07K2319/735 ,  C12N2760/18522 ,  C12N2760/18534

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US20240034773A1

公开(公告)日：2024-02-01

申请号：US18323166

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K2039/5252 ,  C07K14/005 ,  A61K39/12

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.