公开(公告)号：US20230357371A1

公开(公告)日：2023-11-09

申请号：US18323192

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230357369A1

公开(公告)日：2023-11-09

申请号：US18323177

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  C07K16/10

CPC classification number: C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230303669A1

公开(公告)日：2023-09-28

申请号：US18323215

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20220372115A1

公开(公告)日：2022-11-24

申请号：US17848176

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20240299527A1

公开(公告)日：2024-09-12

申请号：US18667046

申请日：2024-05-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Philip R. DORMITZER

IPC: A61K39/155 ,  A61K39/00 ,  A61K39/12 ,  A61P31/14

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61P31/14 ,  A61K2039/545 ,  A61K2039/55 ,  C12N2760/18634

Abstract: The invention relates to an immunization regimen whereby an infant is protected against respiratory syncytial virus (RSV) through administration of a first anti-RSV immune response inducing composition to his or her mother during pregnancy, followed by administration of a second anti-RSV immune response inducing composition to the infant after birth.

公开(公告)号：US20240034773A1

公开(公告)日：2024-02-01

申请号：US18323166

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K2039/5252 ,  C07K14/005 ,  A61K39/12

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230357370A1

公开(公告)日：2023-11-09

申请号：US18323185

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230348575A1

公开(公告)日：2023-11-02

申请号：US18323209

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230348574A1

公开(公告)日：2023-11-02

申请号：US18173006

申请日：2023-02-22

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20220340645A1

公开(公告)日：2022-10-27

申请号：US17848205

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.