公开(公告)号：US11254711B2

公开(公告)日：2022-02-22

申请号：US15735872

申请日：2016-06-10

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Virginia Ammendola ,  Stefano Colloca ,  Riccardo Cortese ,  Fabiana Grazioli ,  Alfredo Nicosia ,  Alessandra Vitelli

IPC: C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  A61K39/12 ,  A61K39/21 ,  C07K14/75 ,  C12N15/861 ,  A61K39/155 ,  C12N7/00 ,  A61K39/00

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of:
(a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,
(b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US11254710B2

公开(公告)日：2022-02-22

申请号：US15735839

申请日：2016-06-10

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Stefano Colloca ,  Virginia Ammendola ,  Fabiana Grazioli ,  Alessandra Franz Vitelli ,  Alfredo Nicosia ,  Riccardo Cortese

IPC: C07H21/04 ,  C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  C07K14/75 ,  A61K39/12 ,  C12N15/861 ,  A61K39/155 ,  A61K39/21 ,  C12N7/00 ,  A61K39/00

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US11214599B2

公开(公告)日：2022-01-04

申请号：US16710131

申请日：2019-12-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano Colloca ,  Alfredo Nicosia ,  Riccardo Cortese ,  Virginia Ammendola ,  Maria Ambrosio

IPC: C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N15/861 ,  A61K39/12 ,  A61K39/235 ,  A61K48/00 ,  A61K39/00

Abstract: The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.