公开(公告)号：US11795478B2

公开(公告)日：2023-10-24

申请号：US17742221

申请日：2022-05-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC: C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  C07K14/005 ,  A61P31/18 ,  A61P31/14 ,  A61K39/00

CPC classification number: C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61P31/14 ,  A61P31/18 ,  C07K14/005 ,  A61K2039/572 ,  C12N2710/10343 ,  C12N2740/16034 ,  C12N2740/16234 ,  C12N2760/20134

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US11352643B2

公开(公告)日：2022-06-07

申请号：US16756373

申请日：2018-10-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano Colloca

IPC: C12N15/86 ,  C12N15/861 ,  A61P37/04 ,  A61K39/155 ,  A61K39/00

Abstract: A new promoter comprising: (i) an hCMV enhancer sequence; (ii) an hCMV promoter sequence; (iii) a splice donor region; (iv) a cell-derived enhancer sequence; and (v) a splice acceptor region.

公开(公告)号：US20170044571A1

公开(公告)日：2017-02-16

申请号：US15339225

申请日：2016-10-31

Applicant: The Government of the United States of America as Represented by the Secretary of the Department of ,  GlaxoSmithKline Biologicals SA

Inventor： Nancy J. Sullivan ,  Gary J Nabel ,  Clement Asiedu ,  Cheng Cheng ,  Alfredo Nicosia ,  Riccardo Cortese ,  Virginia Ammendola ,  Stefano Colloca

IPC: C12N15/86 ,  C12N7/00 ,  C07K14/005

Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).

Abstract translation: 本发明提供用于诱导免疫应答的疫苗和针对用于人类预防性疫苗的禽流感病毒感染的保护。 特别地，本发明提供了表达来自不同的埃博病毒（EBOV）或马尔堡病毒（MARV）病毒的病毒蛋白的黑猩猩腺病毒载体。

公开(公告)号：US12180512B2

公开(公告)日：2024-12-31

申请号：US18453078

申请日：2023-08-21

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano Colloca

IPC: C12N15/00 ,  A61K39/235 ,  C12N7/00 ,  C12N15/86 ,  A61K39/00

Abstract: A simian adenoviral vector comprising two expression cassettes, wherein each expression cassette comprises a transgene and a promoter, and wherein the first expression cassette is inserted in the E1 region of the simian adenoviral vector, and the second expression cassette is inserted in a region of the adenoviral vector that is compatible with vector replication.

公开(公告)号：US11414679B2

公开(公告)日：2022-08-16

申请号：US16466683

申请日：2017-12-07

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC: C12N15/86 ,  C07K14/005 ,  A61K39/21 ,  A61K39/12 ,  A61P31/18 ,  A61P31/14 ,  A61K39/00

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US10584355B2

公开(公告)日：2020-03-10

申请号：US15339225

申请日：2016-10-31

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Nancy J. Sullivan ,  Gary J Nabel ,  Clement Asiedu ,  Cheng Cheng ,  Alfredo Nicosia ,  Riccardo Cortese ,  Virginia Ammendola ,  Stefano Colloca

IPC: C12N15/86 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

Abstract: This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).

公开(公告)号：US11702674B2

公开(公告)日：2023-07-18

申请号：US16973630

申请日：2019-06-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia Ammendola ,  Stefania Capone ,  Stefano Colloca ,  Antonella Folgori ,  Rossella Merone

IPC: C12N15/86 ,  A61K39/235 ,  A61P37/04 ,  A61K39/21 ,  A61K39/00 ,  A61K39/12

CPC classification number: C12N15/86 ,  A61K39/235 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61P37/04 ,  C12N2710/10322 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2740/16034 ,  C12N2740/16071

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US11254711B2

公开(公告)日：2022-02-22

申请号：US15735872

申请日：2016-06-10

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Virginia Ammendola ,  Stefano Colloca ,  Riccardo Cortese ,  Fabiana Grazioli ,  Alfredo Nicosia ,  Alessandra Vitelli

IPC: C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  A61K39/12 ,  A61K39/21 ,  C07K14/75 ,  C12N15/861 ,  A61K39/155 ,  C12N7/00 ,  A61K39/00

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of:
(a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,
(b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US11254710B2

公开(公告)日：2022-02-22

申请号：US15735839

申请日：2016-06-10

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Stefano Colloca ,  Virginia Ammendola ,  Fabiana Grazioli ,  Alessandra Franz Vitelli ,  Alfredo Nicosia ,  Riccardo Cortese

IPC: C07H21/04 ,  C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  C07K14/75 ,  A61K39/12 ,  C12N15/861 ,  A61K39/155 ,  A61K39/21 ,  C12N7/00 ,  A61K39/00

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US11214599B2

公开(公告)日：2022-01-04

申请号：US16710131

申请日：2019-12-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano Colloca ,  Alfredo Nicosia ,  Riccardo Cortese ,  Virginia Ammendola ,  Maria Ambrosio

IPC: C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N15/861 ,  A61K39/12 ,  A61K39/235 ,  A61K48/00 ,  A61K39/00

Abstract: The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.