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公开(公告)号：US20110009423A1
公开(公告)日：2011-01-13
申请号：US12700521
申请日：2010-02-04
申请人： Thomas Ruhland , Garrick P. Smith , Benny Bang-Andersen , Ask Puschl , Ejner K. Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick P. Smith , Benny Bang-Andersen , Ask Puschl , Ejner K. Moltzen , Kim Andersen
IPC分类号： A61K31/495 , C07D211/30 , A61K31/451 , C07D211/70 , A61K31/4418 , C07D241/04 , A61P25/00
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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12.发明申请4-(2-Phenylsulfanyl-phenyl)-1,2,3,6- tetrahydropyridine derivatives as serotonin reuptake inhibitors 审中-公开4-（2-苯硫基 - 苯基）-1,2,3,6-四氢吡啶衍生物作为血清素再摄取抑制剂公开(公告)号：US20070173522A1
公开(公告)日：2007-07-26
申请号：US10551869
申请日：2004-04-02
申请人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
发明人： Ask Puschl , Benny Bang-Andersen , Morten Jorgensen , Karsten Juhl , Thomas Ruhland , Kim Andersen , Jan Kehler
IPC分类号： A61K31/44 , C07D211/70
CPC分类号： C07D211/70 , C07D405/12
摘要： The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式（I）表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US07138407B2
公开(公告)日：2006-11-21
申请号：US11296835
申请日：2005-12-06
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/4409 , C07D211/70
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号：US07342015B2
公开(公告)日：2008-03-11
申请号：US10482762
申请日：2002-06-27
申请人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/497 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12 , C07D409/14
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis
摘要翻译： 具有式（I）的杂芳基衍生物。 本发明的化合物被认为可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社会恐惧症和进食障碍，以及神经系统疾病如精神病
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公开(公告)号：US06492374B2
公开(公告)日：2002-12-10
申请号：US09874392
申请日：2001-06-04
申请人： Kim Andersen , Mario Rottländer , Klaus Peter Bøgesø , Henrik Pedersen , Thomas Ruhland , Robert Dancer
发明人： Kim Andersen , Mario Rottländer , Klaus Peter Bøgesø , Henrik Pedersen , Thomas Ruhland , Robert Dancer
IPC分类号： C07D40506
CPC分类号： C07D307/87 , C07D405/12 , C07D405/14 , C07D407/12 , C07D471/04
摘要： The present invention relates to benzofuran derivatives having general Formula (I) wherein A is selected from (1), (2), (3), (4) wherein Z is O or S; s is 0 or 1; q is 0 or 1; R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C26-alkynyl, C1-6-alkyl-aryl, or C1-6-alkyl-O-aryl; D is a spacer group selected from branched or straight chain C1-6-alkylene, C2-6-alkenylene and C2-6-alkynylene; its enantiomers, and pharmaceutically acceptable acid addition salt thereof. The compounds are potently binding to the 5-HT1A receptor.
摘要翻译： 本发明涉及具有通式（I）的苯并呋喃衍生物，其中A选自（1），（2），（3），（4）其中Z是O或S; s为0或1; q为0或1; R 4是氢，C 1-6 - 烷基，C 2-6烯基，C 2-6炔基，C 1-6 - 烷基 - 芳基或C 1-6 - 烷基-O-芳基; D是选自支链或直链C 1-6 - 亚烷基，C 2-6亚烯基和C 2-6亚炔基的间隔基; 其对映体及其药学上可接受的酸加成盐。 这些化合物与5-HT1A受体有很强的结合。
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公开(公告)号：US20120302553A1
公开(公告)日：2012-11-29
申请号：US13367065
申请日：2012-02-06
申请人： Thomas Ruhland , Garrick P. Smith , Benny Bang-Anderson , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick P. Smith , Benny Bang-Anderson , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/551 , A61K31/495 , C07D243/08 , C07D213/32 , C07D241/04 , C07D211/20 , A61K31/451 , A61P25/24 , A61P25/22 , A61P25/00 , C07D295/096 , A61K31/4418
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US08110567B2
公开(公告)日：2012-02-07
申请号：US12700521
申请日：2010-02-04
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
IPC分类号： A61P25/22 , A61K31/55 , C07D403/00 , C07D243/00
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US07683053B2
公开(公告)日：2010-03-23
申请号：US11551188
申请日：2006-10-19
IPC分类号： A61P25/00 , A61K31/55 , C07D243/08
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US07144884B2
公开(公告)日：2006-12-05
申请号：US10488280
申请日：2002-10-02
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/495 , C07D295/096 , C07D241/04 , C07D211/54 , C07D211/70
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症和恐慌症以及强迫症
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公开(公告)号：US07148238B2
公开(公告)日：2006-12-12
申请号：US11296836
申请日：2005-12-06
申请人： Thomas Ruhland , Benny Bang-Andersen , Ask Puschl
发明人： Thomas Ruhland , Benny Bang-Andersen , Ask Puschl
IPC分类号： A61K31/451 , C07D211/22
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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