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公开(公告)号：US07393845B2
公开(公告)日：2008-07-01
申请号：US11758511
申请日：2007-06-05
申请人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/536 , A61K31/496 , C07D405/12 , C07D413/12
CPC分类号： C07D401/12 , C07D405/12 , C07D409/14 , C07D413/12
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis
摘要翻译： 具有式（I）的杂芳基衍生物。 本发明的化合物被认为可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社会恐惧症和进食障碍，以及神经系统疾病如精神病
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公开(公告)号：US07342015B2
公开(公告)日：2008-03-11
申请号：US10482762
申请日：2002-06-27
申请人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/497 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12 , C07D409/14
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis
摘要翻译： 具有式（I）的杂芳基衍生物。 本发明的化合物被认为可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社会恐惧症和进食障碍，以及神经系统疾病如精神病
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3.发明授权公开(公告)号：US06699864B2
公开(公告)日：2004-03-02
申请号：US10177261
申请日：2002-06-20
申请人： Thomas Ruhland , Christian Krog-Jensen , Mario Rottländer , Gitte Mikkelsen , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Christian Krog-Jensen , Mario Rottländer , Gitte Mikkelsen , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K315377
CPC分类号： C07D405/12 , C07D209/14 , C07D471/04
摘要： The present invention provides compounds of the formula: wherein R1-R8, X, Y, Z, n and m are defined in the application. The compounds of the invention have affinity for the 5-HT1A receptor.
摘要翻译： 本发明提供下式的化合物：其中R 1 -R 8，X，Y，Z，n和m定义在本申请中。本发明化合物对5-HT 1A受体具有亲和力。
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公开(公告)号：US20060258678A1
公开(公告)日：2006-11-16
申请号：US10482762
申请日：2002-06-27
申请人： Mario Rottländer , Ejner Moltzen , Ivan Mikkelsen , Thomas Tuhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Moltzen , Ivan Mikkelsen , Thomas Tuhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/496 , C07D403/14
CPC分类号： C07D401/12 , C07D403/12 , C07D409/14
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis.
摘要翻译： 具有式（I）的杂芳基衍生物。 认为本发明的化合物可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社交恐惧症和进食障碍以及神经障碍如精神病。
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公开(公告)号：US20080027071A1
公开(公告)日：2008-01-31
申请号：US11758511
申请日：2007-06-05
申请人： Mario Rottlander , Ejner Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottlander , Ejner Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/496 , A61K31/506 , A61P25/00 , C07D401/14 , C07D403/14 , C07D405/14
CPC分类号： C07D401/12 , C07D405/12 , C07D409/14 , C07D413/12
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis.
摘要翻译： 具有式（I）的杂芳基衍生物。 认为本发明的化合物可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社交恐惧症和进食障碍以及神经障碍如精神病。
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公开(公告)号：US20120302553A1
公开(公告)日：2012-11-29
申请号：US13367065
申请日：2012-02-06
申请人： Thomas Ruhland , Garrick P. Smith , Benny Bang-Anderson , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick P. Smith , Benny Bang-Anderson , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/551 , A61K31/495 , C07D243/08 , C07D213/32 , C07D241/04 , C07D211/20 , A61K31/451 , A61P25/24 , A61P25/22 , A61P25/00 , C07D295/096 , A61K31/4418
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US08110567B2
公开(公告)日：2012-02-07
申请号：US12700521
申请日：2010-02-04
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ejner Knud Moltzen , Kim Andersen , Ask Puschl
IPC分类号： A61P25/22 , A61K31/55 , C07D403/00 , C07D243/00
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US07683053B2
公开(公告)日：2010-03-23
申请号：US11551188
申请日：2006-10-19
IPC分类号： A61P25/00 , A61K31/55 , C07D243/08
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US07144884B2
公开(公告)日：2006-12-05
申请号：US10488280
申请日：2002-10-02
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/495 , C07D295/096 , C07D241/04 , C07D211/54 , C07D211/70
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症和恐慌症以及强迫症
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公开(公告)号：US07138407B2
公开(公告)日：2006-11-21
申请号：US11296835
申请日：2005-12-06
申请人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K31/4409 , C07D211/70
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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