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公开(公告)号：US07393845B2
公开(公告)日：2008-07-01
申请号：US11758511
申请日：2007-06-05
申请人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/536 , A61K31/496 , C07D405/12 , C07D413/12
CPC分类号： C07D401/12 , C07D405/12 , C07D409/14 , C07D413/12
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis
摘要翻译： 具有式（I）的杂芳基衍生物。 本发明的化合物被认为可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社会恐惧症和进食障碍，以及神经系统疾病如精神病
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公开(公告)号：US07342015B2
公开(公告)日：2008-03-11
申请号：US10482762
申请日：2002-06-27
申请人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/497 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12 , C07D409/14
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis
摘要翻译： 具有式（I）的杂芳基衍生物。 本发明的化合物被认为可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社会恐惧症和进食障碍，以及神经系统疾病如精神病
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公开(公告)号：US20060258678A1
公开(公告)日：2006-11-16
申请号：US10482762
申请日：2002-06-27
申请人： Mario Rottländer , Ejner Moltzen , Ivan Mikkelsen , Thomas Tuhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Moltzen , Ivan Mikkelsen , Thomas Tuhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/496 , C07D403/14
CPC分类号： C07D401/12 , C07D403/12 , C07D409/14
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis.
摘要翻译： 具有式（I）的杂芳基衍生物。 认为本发明的化合物可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社交恐惧症和进食障碍以及神经障碍如精神病。
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公开(公告)号：US20080027071A1
公开(公告)日：2008-01-31
申请号：US11758511
申请日：2007-06-05
申请人： Mario Rottlander , Ejner Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottlander , Ejner Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/496 , A61K31/506 , A61P25/00 , C07D401/14 , C07D403/14 , C07D405/14
CPC分类号： C07D401/12 , C07D405/12 , C07D409/14 , C07D413/12
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis.
摘要翻译： 具有式（I）的杂芳基衍生物。 认为本发明的化合物可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社交恐惧症和进食障碍以及神经障碍如精神病。
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5.发明授权4,5,6 and 7-indole and indoline derivatitives, their preparation and use 失效4,5,6和7-吲哚和二氢吲哚衍生物，其制备和用途公开(公告)号：US06391882B1
公开(公告)日：2002-05-21
申请号：US09719849
申请日：2001-02-02
IPC分类号： A61K31495
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14
摘要： A substituted 4-, 5-, 6-, and 7-indole derivative of Formula (I) wherein A is a group having formula (IIA), (IIB), (IIC) wherein X, U, Y, R3 to R12, Z, W, n and m are as defined above. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
摘要翻译： 其中A是具有式（IIA），（IIB），（IIC）的基团的取代的4-，5-，6-和7-吲哚衍生物，其中X，U，Y，R 3至R 12， Z，W，n和m如上所定义。 该化合物是有效的5-羟色胺再摄取抑制剂，具有5-HT1A受体拮抗作用。
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6.发明授权公开(公告)号：US06476035B1
公开(公告)日：2002-11-05
申请号：US09491204
申请日：2000-01-25
IPC分类号： A61K31496
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
摘要翻译： 本发明涉及具有式（I）的吲哚和2,3-二氢吲哚衍生物或其任何对映体或其任何混合物或其酸加成盐，其中A，R 1，R 2，R 3，W，X ，Y和Z如说明书所述。 该化合物是有效的5-羟色胺再摄取抑制剂，具有5-HT1A受体拮抗作用。
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7.发明授权公开(公告)号：US06727263B2
公开(公告)日：2004-04-27
申请号：US10223046
申请日：2002-08-16
IPC分类号： A61K314439
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
摘要翻译： 本发明涉及具有式（I）的吲哚和2,3-二氢吲哚衍生物或其任何对映体或其任何混合物或其酸加成盐，其中A，R 1，R 2， R 3，W，X，Y和Z如说明书所述。 该化合物是有效的5-羟色胺再摄取抑制剂，具有5-HT1A受体拮抗作用。
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公开(公告)号：US06352988B2
公开(公告)日：2002-03-05
申请号：US09814037
申请日：2001-03-21
申请人： Jens Kristian Perregaard , Benny Bang-Andersen , Henrik Pedersen , Ivan Mikkelsen , Robert Dancer
发明人： Jens Kristian Perregaard , Benny Bang-Andersen , Henrik Pedersen , Ivan Mikkelsen , Robert Dancer
IPC分类号： A61K31496
CPC分类号： C07D401/04 , C07D209/08 , C07D209/14 , C07D401/14 , C07D491/04 , G11C5/025 , G11C7/1048
摘要： The present invention relates to substituted indane or dihydroindole compounds of Formula (I) wherein A is an indole. These compounds have high affinity for D4 receptors.
摘要翻译： 本发明涉及式（I）的取代的茚满或二氢吲哚化合物，其中A是吲哚。 这些化合物对D4受体具有高亲和力。
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公开(公告)号：US06262087B1
公开(公告)日：2001-07-17
申请号：US09331560
申请日：1999-06-21
申请人： Jens Kristian Perregaard , Benny Bang-Andersen , Henrik Pedersen , Ivan Mikkelsen , Robert Dancer
发明人： Jens Kristian Perregaard , Benny Bang-Andersen , Henrik Pedersen , Ivan Mikkelsen , Robert Dancer
IPC分类号： A61K31445
CPC分类号： C07D401/04 , C07D209/08 , C07D209/14 , C07D401/14 , C07D491/04 , G11C5/025 , G11C7/1048
摘要： The present invention relates to substituted indane or dihydroindole compounds of Formula (I) wherein A is an indole. These compounds have high affinity for D4 receptors.
摘要翻译： 本发明涉及式（I）的取代的茚满或二氢吲哚化合物，其中A是吲哚。 这些化合物对D4受体具有高亲和力。
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公开(公告)号：US06436940B1
公开(公告)日：2002-08-20
申请号：US09915680
申请日：2001-07-26
IPC分类号： A61K31496
摘要： The present invention relates to substituted indane or dihydroindole compounds of Formula (I), wherein A and B are independently O or S; D is an optionally substituted methylene group; X is N or optionally substituted C; and W is a spacer group. The compounds are either selective dopamine D4 ligands or they have combined effects at dopamine D4 and serotonergic receptors and/or the serotonergic transporter. These compounds are therefore useful in the treatment of certain psychiatric and neurologic disorders, including psychosis, depression and anxiety.
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