公开(公告)号：US20160304450A1

公开(公告)日：2016-10-20

申请号：US14972333

申请日：2015-12-17

Applicant: Genentech, Inc.

Inventor： Jun Liang ,  Daniel Fred Ortwine ,  Xiaojing Wang ,  Steven P. Govek ,  Mehmet Kahraman ,  Johnny Y. Nagasawa ,  Nicholas D. Smith ,  Simon Charles Goodacre ,  Nicholas Charles Ray

IPC: C07D205/04 ,  A61K31/404 ,  A61K45/06 ,  A61K31/397 ,  C07D207/04 ,  A61K31/40 ,  C07D409/12 ,  A61K31/4025 ,  C07D413/12 ,  A61K31/422 ,  C07D417/12 ,  A61K31/427 ,  C07D401/14 ,  A61K31/4439 ,  C07D411/12 ,  C07D403/12

CPC classification number: C07D205/04 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/416 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5415 ,  A61K45/06 ,  C07D207/04 ,  C07D207/08 ,  C07D401/14 ,  C07D403/02 ,  C07D403/12 ,  C07D403/14 ,  C07D409/02 ,  C07D409/12 ,  C07D411/02 ,  C07D411/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D493/04 ,  A61K2300/00

Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US20160297767A1

公开(公告)日：2016-10-13

申请号：US15186246

申请日：2016-06-17

Applicant: GENENTECH, INC.

Inventor： Nicholas D. Smith ,  Mehmet Kahraman ,  Steven P. Govek ,  Johnny Y. Nagasawa ,  Andiliy G. Lai ,  Jackaline D. Julien ,  Mark R. Herbert ,  Celine Bonnefous ,  Karensa L. Douglas

IPC: C07D231/56 ,  C07C215/10

CPC classification number: C07D231/56 ,  A61K31/416 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  C07C215/10 ,  C07D209/08 ,  C07D215/227 ,  C07D217/24 ,  C07D249/18 ,  C07D265/18 ,  C07D277/68 ,  C07D279/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D495/04

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US20160090378A1

公开(公告)日：2016-03-31

申请号：US14963658

申请日：2015-12-09

Applicant: Genentech, Inc.

Inventor： Mehmet Kahraman ,  Steven P. Govek ,  Nicholas D. Smith ,  Jeffrey H. Hager ,  Edna Chow Maneval

IPC: C07D405/12 ,  A61K45/06 ,  A61K31/397

CPC classification number: C07D405/12 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/2054 ,  A61K9/4866 ,  A61K31/397 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K2300/00

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US09873684B2

公开(公告)日：2018-01-23

申请号：US14963658

申请日：2015-12-09

Applicant: Genentech, Inc.

Inventor： Mehmet Kahraman ,  Steven P. Govek ,  Nicholas D. Smith ,  Jeffrey H. Hager ,  Edna Chow Maneval

IPC: C07D405/12 ,  A61K45/06 ,  A61K31/397 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K9/20 ,  A61K9/48

CPC classification number: C07D405/12 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/2054 ,  A61K9/4866 ,  A61K31/397 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K2300/00

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US20170197915A9

公开(公告)日：2017-07-13

申请号：US14972333

申请日：2015-12-17

Applicant: Genentech, Inc.

Inventor： Jun Liang ,  Daniel Fred Ortwine ,  Xiaojing Wang ,  Steven P. Govek ,  Mehmet Kahraman ,  Johnny Y. Nagasawa ,  Nicholas D. Smith ,  Simon Charles Goodacre ,  Nicholas Charles Ray

IPC: C07D205/04 ,  A61K31/404 ,  A61K45/06 ,  A61K31/397 ,  C07D207/04 ,  A61K31/40 ,  C07D409/12 ,  A61K31/4025 ,  C07D413/12 ,  A61K31/422 ,  C07D417/12 ,  A61K31/427 ,  C07D401/14 ,  A61K31/4439 ,  C07D411/12 ,  C07D403/12

CPC classification number: C07D205/04 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/416 ,  A61K31/422 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5415 ,  A61K45/06 ,  C07D207/04 ,  C07D207/08 ,  C07D401/14 ,  C07D403/02 ,  C07D403/12 ,  C07D403/14 ,  C07D409/02 ,  C07D409/12 ,  C07D411/02 ,  C07D411/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D493/04 ,  A61K2300/00

Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US09475798B2

公开(公告)日：2016-10-25

申请号：US14963653

申请日：2015-12-09

Applicant: Genentech, Inc.

Inventor： Steven P. Govek ,  Mehmet Kahraman ,  Nicholas D. Smith ,  Jeffrey H. Hager ,  Edna Chow Maneval

IPC: C07D405/12 ,  A61K45/06 ,  A61K31/397

CPC classification number: A61K31/397 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K45/06 ,  C07D405/12

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract translation: 本文描述的是雌激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。