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公开(公告)号：US10053451B2
公开(公告)日：2018-08-21
申请号：US15164102
申请日：2016-05-25
Applicant: Genentech, Inc.
Inventor： Sharada Labadie , Jun Liang , Daniel Fred Ortwine , Xiaojing Wang , Birong Zhang , Nicholas D. Smith , Steven P. Govek , Mehmet Kahraman , Andiliy G. Lai , Johnny Y. Nagasawa , Simon Charles Goodacre , Nicholas Charles Ray
IPC: C07D405/14 , A61K31/497 , A61K31/397 , C07D491/052 , A61K31/4162 , C07D405/12 , A61K31/4439 , A61K31/416 , C07D405/04
CPC classification number: C07D405/14 , A61K31/397 , A61K31/416 , A61K31/4162 , A61K31/4439 , A61K31/497 , C07D405/04 , C07D405/12 , C07D491/052
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US10227334B2
公开(公告)日：2019-03-12
申请号：US15620304
申请日：2017-06-12
Applicant: Genentech, Inc.
Inventor： Mehmet Kahraman , Steven P. Govek , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: C07D405/12 , A61K31/397 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/38 , A61K9/00 , A61K9/20 , A61K9/48
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20160347742A1
公开(公告)日：2016-12-01
申请号：US15164102
申请日：2016-05-25
Applicant: Genentech, Inc.
Inventor： Sharada Labadie , Jun Liang , Daniel Fred Ortwine , Xiaojing Wang , Birong Zhang , Nicholas D. Smith , Steven P. Govek , Mehmet Kahraman , Andiliy G. Lai , Johnny Y. Nagasawa , Simon Charles Goodacre , Nicholas Charles Ray
IPC: C07D405/14 , A61K31/497 , A61K31/397 , C07D491/052 , A61K31/4162 , C07D405/12 , A61K31/4439 , A61K31/416
CPC classification number: C07D405/14 , A61K31/397 , A61K31/416 , A61K31/4162 , A61K31/4439 , A61K31/497 , C07D405/04 , C07D405/12 , C07D491/052
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
Abstract translation: 本文描述的是雌激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。
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公开(公告)号：US09845291B2
公开(公告)日：2017-12-19
申请号：US14972333
申请日：2015-12-17
Applicant: Genentech, Inc.
Inventor： Jun Liang , Daniel Fred Ortwine , Xiaojing Wang , Steven P. Govek , Mehmet Kahraman , Johnny Y. Nagasawa , Nicholas D. Smith , Simon Charles Goodacre , Nicholas Charles Ray
IPC: A61K31/397 , C07D205/04 , C07D403/12 , A61K31/404 , A61K45/06 , C07D207/04 , A61K31/40 , C07D409/12 , A61K31/4025 , C07D413/12 , A61K31/422 , C07D417/12 , A61K31/427 , C07D401/14 , A61K31/4439 , C07D411/12
CPC classification number: C07D205/04 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/416 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/5415 , A61K45/06 , C07D207/04 , C07D207/08 , C07D401/14 , C07D403/02 , C07D403/12 , C07D403/14 , C07D409/02 , C07D409/12 , C07D411/02 , C07D411/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D493/04 , A61K2300/00
Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20160175284A1
公开(公告)日：2016-06-23
申请号：US14972336
申请日：2015-12-17
Applicant: Genentech, Inc.
Inventor： Sharada Labadie , Jun Li , Jun Liang , Daniel Fred Ortwine , Xiaojing Wang , Jason Zbieg , Steven P. Govek , Mehmet Kahraman , Johnny Y. Nagasawa , Nicholas D. Smith
IPC: A61K31/4025 , C07D401/12 , A61K31/4184 , C07D401/14 , A61K31/404 , A61K45/06 , A61K31/397
CPC classification number: A61K31/4025 , A61K31/397 , A61K31/404 , A61K31/4184 , A61K45/06 , C07D311/14 , C07D401/12 , C07D401/14
Abstract: Described herein are compounds that are estrogen receptor modulators of Formula I: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
Abstract translation: 本文描述的是作为式I的雌激素受体调节剂的化合物：及其立体异构体，互变异构体或其药学上可接受的盐，以及本文所述的取代基和结构特征。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。
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Patent Agency Ranking
公开(公告)号：US20160090377A1
公开(公告)日：2016-03-31
申请号：US14963653
申请日：2015-12-09
Applicant: Genentech, Inc.
Inventor： Steven P. Govek , Mehmet Kahraman , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: C07D405/12 , A61K45/06 , A61K31/397
CPC classification number: A61K31/397 , A61K9/0014 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K45/06 , C07D405/12
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US09868704B2
公开(公告)日：2018-01-16
申请号：US15186246
申请日：2016-06-17
Applicant: GENENTECH, INC.
Inventor： Nicholas D. Smith , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Mark R. Herbert , Karensa L. Douglas
IPC: C07D231/56 , A61K31/416 , C07D209/08 , C07D249/18 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07D215/227 , C07D217/24 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D409/10 , C07D471/04 , C07D495/04 , C07D401/12 , C07D403/10 , C07D413/10 , C07D417/10 , C07C215/10
CPC classification number: C07D231/56 , A61K31/416 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07C215/10 , C07D209/08 , C07D215/227 , C07D217/24 , C07D249/18 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D495/04
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20170275273A1
公开(公告)日：2017-09-28
申请号：US15620304
申请日：2017-06-12
Applicant: Genentech, Inc.
Inventor： Mehmet Kahraman , Steven P. Govek , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: C07D405/12 , A61K9/00 , A61K47/10 , A61K45/06 , A61K47/14 , A61K31/397 , A61K9/48 , A61K47/38 , A61K9/20
CPC classification number: C07D405/12 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/2054 , A61K9/4866 , A61K31/397 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/38 , A61K2300/00
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US09655880B2
公开(公告)日：2017-05-23
申请号：US15256879
申请日：2016-09-06
Applicant: Genentech, Inc.
Inventor： Steven P. Govek , Mehmet Kahraman , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: A61K31/397 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48 , A61K45/06 , A61K9/06 , C07D405/12
CPC classification number: A61K31/397 , A61K9/0014 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K45/06 , C07D405/12
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20160367526A1
公开(公告)日：2016-12-22
申请号：US15256879
申请日：2016-09-06
Applicant: Genentech, Inc.
Inventor： Steven P. Govek , Mehmet Kahraman , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
CPC classification number: A61K31/397 , A61K9/0014 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K45/06 , C07D405/12
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
Abstract translation: 本文描述的是雌激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。
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