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公开(公告)号：US10800780B2
公开(公告)日：2020-10-13
申请号：US16065397
申请日：2016-12-23
Applicant: Genentech, Inc. , NewLink Genetics Corporation
Inventor： Xingyu Lin , Po-wai Yuen , Rohan Mendonca , Brendan Parr , Richard Pastor , Zhonghua Pei , Lewis Gazzard , Firoz Jaipuri , Sanjeev Kumar , Xiaokai Li , Roheeth Pavana , Hima Potturi , Venkata Velvadapu , Jesse Waldo , Zuhui Zhang , Guosheng Wu , Benjamin Douglas Sellers
IPC: A61K31/4188 , A61K31/407 , A61K31/4035 , C07D487/04 , C07D519/00 , A61P35/00 , A61K45/06 , A61K38/16
Abstract: Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
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公开(公告)号：US20180298033A1
公开(公告)日：2018-10-18
申请号：US15842642
申请日：2017-12-14
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US09605005B2
公开(公告)日：2017-03-28
申请号：US15074100
申请日：2016-03-18
Applicant: Genentech, Inc.
Inventor： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Jason Burch
IPC: C07D401/00 , C07D513/04 , C07D401/14 , C07D413/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
CPC classification number: C07D513/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
Abstract: The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
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公开(公告)号：US20150057260A1
公开(公告)日：2015-02-26
申请号：US14466176
申请日：2014-08-22
Applicant: Genentech, Inc.
Inventor： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Xingyu Lin , Jason Burch
IPC: C07D495/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D491/107 , C07D403/14 , C07D401/10
CPC classification number: C07D401/10 , A61K31/395 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/107 , C07D495/04 , C07D495/06
Abstract: The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
Abstract translation: 本发明涉及式（O）的化合物：其中A1-A8，R4和R5各自具有如本文所述的含义。 式（0）的化合物及其药物组合物可用于治疗其中观察到NF-kB信号传导的不期望或过度活化的疾病和病症。
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公开(公告)号：US20220306635A1
公开(公告)日：2022-09-29
申请号：US17068574
申请日：2020-10-12
Applicant: Genentech, Inc. , NewLink Genetics Corporation
Inventor： Xingyu Lin , Po-wai Yuen , Rohan Mendonca , Brendan Parr , Richard Pastor , Zhonghua Pei , Lewis Gazzard , Firoz Jaipuri , Sanjeev Kumar , Xiaokai Li , Roheeth Pavana , Hima Potturi , Venkata Velvadapu , Jesse Waldo , Zuhui Zhang , Guosheng Wu , Benjamin Douglas Sellers
IPC: C07D487/04 , A61P35/00 , A61K38/16 , A61K45/06 , C07D519/00
Abstract: Presently provided are inhibitors of cellularly expressed TD02 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
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Patent Agency Ranking
公开(公告)号：US20190233441A1
公开(公告)日：2019-08-01
申请号：US16373435
申请日：2019-04-02
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20190016726A1
公开(公告)日：2019-01-17
申请号：US16065397
申请日：2016-12-23
Applicant: Genentech, Inc. , NewLink Genetics Corporation
Inventor： Xingyu Lin , Po-wai Yuen , Rohan Mendonca , Brendan Parr , Richard Pastor , Zhonghua Pei , Lewis Gazzard , Firoz Jaipuri , Sanjeev Kumar , Xiaokai Li , Roheeth Pavana , Hima Potturi , Venkata Velvadapu , Jesse Waldo , Zuhui Zhang , Guosheng Wu
IPC: C07D487/04 , A61P35/00 , C07D519/00 , A61K38/16
Abstract: Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
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公开(公告)号：US09873709B2
公开(公告)日：2018-01-23
申请号：US15499662
申请日：2017-04-27
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20170210724A1
公开(公告)日：2017-07-27
申请号：US15481852
申请日：2017-04-07
Applicant: Genentech, Inc.
Inventor： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Xingyu Lin , Jason Burch
IPC: C07D401/10 , C07D401/14 , C07D491/107 , C07D409/14 , C07D405/14 , C07D495/04 , C07D495/06 , C07D471/04 , C07D487/04 , C07D413/10 , C07D403/10 , C07D405/10 , C07D417/14 , C07D491/048 , C07D413/14
CPC classification number: C07D401/10 , A61K31/395 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/107 , C07D495/04 , C07D495/06
Abstract: The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
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公开(公告)号：US20170145034A1
公开(公告)日：2017-05-25
申请号：US15425698
申请日：2017-02-06
Applicant: Genentech, Inc.
Inventor： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Jason Burch
IPC: C07D513/04 , C07D401/14 , C07D491/052 , C07D471/04 , C07D413/10 , C07D491/048 , C07D403/14 , C07D413/14 , C07D495/04 , C07D487/04 , C07D417/10 , C07D403/10 , C07D401/10
CPC classification number: C07D513/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
Abstract: The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
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