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公开(公告)号：US10258603B2
公开(公告)日：2019-04-16
申请号：US15592012
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: A61K31/40 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10150767B2
公开(公告)日：2018-12-11
申请号：US15592017
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: C07D471/04 , A61K31/437 , C07D519/00 , A61K31/4985 , A61K31/496 , A61K31/4545 , A61K45/06
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10308614B2
公开(公告)日：2019-06-04
申请号：US15686028
申请日：2017-08-24
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor
IPC: C07D237/20 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D498/10 , A61K31/50 , A61K31/51 , C07D401/12 , C07D237/22 , C07D417/14 , C07D413/12 , C07D451/02 , C07D487/04 , A61K45/06 , A61K31/337 , A61K31/437 , A61K31/501
Abstract: The present invention relates to compounds of formula (I): and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM and/or PB1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various BRG1-mediated disorders, BRM-mediated disorders and/or PB1-mediated disorders.
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公开(公告)号：US10206931B2
公开(公告)日：2019-02-19
申请号：US15482581
申请日：2017-04-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： F. Anthony Romero , Steven R. Magnuson , Richard Pastor , Vickie Hsiao-Wei Tsui , Jeremy Murray , Terry Crawford , Daniel J. Burdick , Brian K. Albrecht , Alexandre Cote , Alexander M. Taylor , Christopher G. Nasveschuck , Yves LeBlanc , Michael Charles Hewitt , Kwong Wah Lai , Kevin Chen
IPC: A61K31/551 , C07D243/12 , C07D403/04 , C07D403/14 , A61K31/55 , C07D223/16 , C07D267/14 , C07D401/14 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/10 , C07D243/24 , C07D471/04 , C07D495/04 , A61K45/06 , A61K31/337 , A61K31/5513
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US20170340604A1
公开(公告)日：2017-11-30
申请号：US15592012
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: A61K31/40 , C07D471/04
CPC classification number: A61K31/40 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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Patent Agency Ranking
公开(公告)号：US20170333406A1
公开(公告)日：2017-11-23
申请号：US15667227
申请日：2017-08-02
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Marc Adler , Brian K. Albrecht , Sarah Bronner , Kevin X. Chen , Alexandre Côté , Terry Crawford , Patrick Cyr , Jackson Egen , Steven Kauder , Kwong Wah Lai , Jiangpeng Liao , Steven Magnuson , Jeremy Murray , Richard Pastor , F. Anthony Romero , Alexander M. Taylor , Vickie Hsiao-Wei Tsui , Fei Wang , Bing-Yan Zhu
IPC: A61K31/437 , C07D471/04 , A61K45/06 , A61K31/55 , A61K31/5415 , A61K31/5377 , A61K31/4375 , A61K31/506 , A61K31/498 , A61K31/496 , A61K31/4725 , A61K31/4709 , C07D519/00 , A61K31/538
CPC classification number: A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US09592235B2
公开(公告)日：2017-03-14
申请号：US15184310
申请日：2016-06-16
Applicant: Genentech, Inc.
Inventor： Huifen Chen , Terry Crawford , Seth F. Harris , Steven R. Magnuson , Chudi Ndubaku , Lan Wang
IPC: A61K31/551 , A61K31/519 , C07D239/94 , C07D471/04 , C07D403/12 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/12 , C07D239/95 , C07D413/12 , A61K31/5377 , A61K31/553
CPC classification number: A61K31/519 , A61K31/5377 , A61K31/551 , A61K31/553 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
Abstract: The invention provides a method of treating cancer in a patient by administering a compound of formula (I): wherein R1 R2 and R3 are as defined herein, compositions including the compounds and methods of using the compounds.
Abstract translation: 本发明提供具有以下通式的新化合物：其中A，R 1，R 2和R 3如本文所定义，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US09586956B2
公开(公告)日：2017-03-07
申请号：US14448941
申请日：2014-07-31
Applicant: Genentech, Inc.
Inventor： Huifen Chen , Terry Crawford , Steven R. Magnuson , Chudi Ndubaku , Lan Wang
IPC: C07D471/04 , C07D401/12 , C07D413/12 , C07D217/22 , C07D217/26 , C07D401/04 , C07D413/04
CPC classification number: C07D471/04 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12
Abstract: The invention provides novel compounds having the general formula: wherein A, R1 and R2 are as described herein, compositions including the compounds and methods of using the compounds.
Abstract translation: 本发明提供具有以下通式的新化合物：其中A，R 1和R 2如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US20160158207A1
公开(公告)日：2016-06-09
申请号：US14952821
申请日：2015-11-25
Applicant: Constellation Pharmaceuticals, Inc. , Genentech, Inc.
Inventor： Marc Adler , Brian K. Albrecht , Sarah Bronner , Kevin X. Chen , Alexandre Côté , Terry Crawford , Patrick Cyr , Jackson Egen , Steven Kauder , Kwong Wah Lai , Jiangpeng Liao , Steven Magnuson , Jeremy Murray , Richard Pastor , F. Anthony Romero , Alexander M. Taylor , Vickie Hsiao-Wei Tsui , Fei Wang , Bing-Yan Zhu
IPC: A61K31/437 , A61K31/538 , A61K31/5415 , A61K31/4709 , A61K31/498 , A61K45/06 , A61K31/55 , C07D519/00 , A61K31/4375 , A61K31/4725 , A61K31/496 , A61K31/5377 , C07D471/04 , A61K31/506
CPC classification number: A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
Abstract translation: 本发明涉及式（I）或式（II）化合物及其盐，其中式（I）的R 1 -R 4和式（II）的R 1 -R 3具有本文定义的任何值，组合物 及其用途。 该化合物可用作CBP和/或EP300的抑制剂。 还包括包含式（II）的式（I）化合物或其药学上可接受的盐的药物组合物，以及在治疗各种CBP和/或EP300介导的病症中使用这些化合物和盐的方法。
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20.发明申请公开(公告)号：US20160024504A1
公开(公告)日：2016-01-28
申请号：US14776051
申请日：2014-03-14
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Terry Crawford , Benjamin Fauber , Hon-Ren Huang , Jose M. Lora , Steven Magnuson , Christopher G. Nasveschuk , Andres Salmeron , Robert J. Sims, III , Alexander M. Taylor
IPC: C12N15/113 , G01N33/50 , A61K31/444 , A61K31/437 , A61K31/496
CPC classification number: C12N15/113 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/713 , C07K14/4702 , C12N2310/14 , C12N2320/30 , G01N33/505 , G01N2333/52 , G01N2500/04 , G01N2500/10 , Y02A50/422
Abstract: The invention provides methods for treating Th2 cytokine-mediated diseases by inhibiting bromodomain function.
Abstract translation: 本发明提供了通过抑制溴结构域功能来治疗Th2细胞因子介导的疾病的方法。
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