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18 条记录 (耗时 0.02 秒)

    Indole derivatives with antibacterial and antimycotic properties
    12.
    发明授权
    Indole derivatives with antibacterial and antimycotic properties 失效
    吲哚衍生物具有抗菌和抗真菌性能

    公开(公告)号：US5569668A

    公开(公告)日：1996-10-29

    申请号：US412455

    申请日：1995-03-29

    申请人： John M. Webster ,  Jianxiong Li ,  Genhui Chen

    发明人： John M. Webster ,  Jianxiong Li ,  Genhui Chen

    IPC分类号： C07D209/14 ,  A61K31/40

    CPC分类号： C07D209/14

    摘要： The invention is drawn to an antibiotic, NEMATOPHIN, 3-indoleethyl 3'-methyl-2-oxo-pentanamide (+stereoisomer, -stereoisomer and racemic mixture) and its derivatives, 3-indoleethyl 2-oxo-alkanamides, 3-indoleethyl 2-oxo-alkanoates with or without substitute(s) on the indole ring, produced by bacterial symbiont Xenorhabdus nematophilus and/or other Xenorhabdus species or synthesized by reaction of tryptamine or substituted tryptamine and 2-oxo-alkanoic acid or its derivative, the additional salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including antibiotic-resistant Staphylococcus.

    摘要翻译： 本发明涉及抗生素NEMATOPHIN，3-吲哚乙基3'-甲基-2-氧代戊酰胺（+立体异构体，立体异构体和外消旋混合物）及其衍生物3-吲哚乙基2-氧代 - 链烷酰胺，3-吲哚乙基2 由吲哚环上有或没有取代基的异硫氰酸酯，由细菌共生型罗氏假单胞菌和/或其他Xenorhabdus物种产生，或通过色胺或取代的色胺和2-氧代 - 链烷酸或其衍生物的反应合成， 其盐，其药物组合物及其作为药物的用途，特别是用于治疗涉及对其敏感的微生物的感染性疾病，包括抗生素抗性葡萄球菌。

    Anticancer property of dithiolopyrrolones
    13.
    发明授权
    Anticancer property of dithiolopyrrolones 失效
    二硫代吡咯啉酮的抗癌性质

    公开(公告)号：US6020360A

    公开(公告)日：2000-02-01

    申请号：US716593

    申请日：1996-09-18

    申请人： John M. Webster ,  Jianxiong Li ,  Genhui Chen

    发明人： John M. Webster ,  Jianxiong Li ,  Genhui Chen

    IPC分类号： A61K31/407 ,  A61K31/40

    CPC分类号： A61K31/407

    摘要： The invention is drawn to a novel use of a group of known compounds with the formula shown below, ##STR1## wherein R.sub.1, R.sub.2 =hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl, aralkyl, or heterocyclic group; R.sub.3 =hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclic group, the salts thereof, the compositions thereof and their use as medicaments, particularly in the treatment of human and animal cancers.

    摘要翻译： 本发明涉及一组具有下列结构的已知化合物的新用途，其中R1，R2 =氢，取代或未取代的烷基，环烷基，酰基，芳基，芳烷基或杂环基; R3 =氢，烷基，环烷基，芳烷基，芳基或杂环基，其盐，其组合物及其作为药物的用途，特别是用于治疗人和动物癌症。

    Antineoplastic agents
    14.
    发明授权
    Antineoplastic agents 有权
    抗肿瘤药

    公开(公告)号：US06583171B1

    公开(公告)日：2003-06-24

    申请号：US09519871

    申请日：2000-03-06

    申请人： John Malcolm Webster ,  Jianxiong Li ,  Genhui Chen

    发明人： John Malcolm Webster ,  Jianxiong Li ,  Genhui Chen

    IPC分类号： A61K3140

    CPC分类号： A61K31/407

    摘要： Compounds, isolated from the bacteria Xenorhabdus bovienil, have antineoplastic activity. The invention provides pharmaceutical compositions containing the compounds and the methods for employing them as medicaments, particularly in the treatment of human and animal cancers.

    摘要翻译： 从细菌Xenorhabdus bovienil分离的化合物具有抗肿瘤活性。 本发明提供含有这些化合物的药物组合物及其用作药物的方法，特别是用于治疗人和动物癌症。

    Heterocyclic compounds with antibacterial and antimycotic properties
    15.
    发明授权
    Heterocyclic compounds with antibacterial and antimycotic properties 失效
    具有抗菌和抗真菌性质的杂环化合物

    公开(公告)号：US06316476B1

    公开(公告)日：2001-11-13

    申请号：US08685211

    申请日：1996-07-23

    申请人： John M. Webster ,  Jianxiong Li ,  Genhui Chen

    发明人： John M. Webster ,  Jianxiong Li ,  Genhui Chen

    IPC分类号： C07D28501

    CPC分类号： C07D495/04 ,  C12P17/185

    摘要： The invention is drawn to novel antibiotics, XENORXIDES of formula shown below, wherein R1, R2=hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl, aralkyl, or heterocyclyl group; R3=hydrogen, alkyl cycloalkyl, aralkyl or aryl group, produced by bacterial symbiont Xenorhabdus bovienii and/or other Xenorhabdus species, and/or by oxidation of the corresponding dithiolopyrrolone derivatives with oxygen and Xenorhabdus species, and/or its cell-free filtrate, the additional salts thereof, the compositions thereof and their use as medicaments and/or agrochemicals, particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including drug-resistant Staphylococcus.

    摘要翻译： 本发明涉及新型抗生素，下文所示的XENORXIDES，其中R1，R2 =氢，取代或未取代的烷基，环烷基，酰基，芳基，芳烷基或杂环基; R3是氢，烷基环烷基，芳烷基或芳基，由细菌共生的罗氏假单胞菌和/或其他异蟑螂属物种产生，和/或通过用氧和异蟑螂种类氧化相应的二硫代吡咯烷酮衍生物和/或其无细胞滤液， 其附加盐，其组合物及其作为药物和/或农用化学品的用途，特别是用于治疗涉及对其敏感的微生物的感染性疾病，包括耐药葡萄球菌。