公开(公告)号：US20160178577A1

公开(公告)日：2016-06-23

申请号：US14577511

申请日：2014-12-19

Applicant: Genia Technologies, Inc.

Inventor： Roger J.A. Chen ,  Hui Tian ,  Bill Maney

IPC: G01N27/447 ,  C12Q1/68 ,  B01L3/00

CPC classification number: G01N27/44791 ,  B01L3/50273 ,  B01L2400/0421 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N33/48721 ,  C12Q2565/607 ,  C12Q2565/631

Abstract: A method of analyzing a molecule in a nanopore is disclosed. A voltage is applied across a nanopore that is inserted in a membrane by coupling the nanopore to a voltage source. The nanopore is decoupled from the voltage source. After the decoupling, a rate of decay of the voltage across the nanopore is determined. A molecule in the nanopore is distinguished from other possible molecules based on the determined rate of decay of the voltage across the nanopore.

Abstract translation: 公开了分析纳米孔中分子的方法。 通过将纳米孔耦合到电压源，跨越插入膜中的纳米孔施加电压。 纳米孔与电压源分离。 在解耦之后，确定纳米孔上电压的衰减速率。 基于确定的纳米孔上的电压衰减速率，纳米孔中的分子与其它可能的分子区分开来。

公开(公告)号：US20160178576A1

公开(公告)日：2016-06-23

申请号：US14575938

申请日：2014-12-18

Applicant: Genia Technologies, Inc.

Inventor： Bill Maney ,  David Bruce Robinson ,  Markus Wallgren ,  Robert A. Yuan

IPC: G01N27/447 ,  G01N27/403

CPC classification number: G01N27/44791 ,  C12Q1/6869 ,  G01N27/403 ,  G01N33/48721 ,  C12Q2527/125 ,  C12Q2565/607 ,  C12Q2565/629 ,  C12Q2565/631

Abstract: A nanopore based sequencing chip package is disclosed. The nanpore based sequencing chip package includes a reservoir defined by a plurality of surfaces. The chip package includes a nanopore cell array comprising a plurality of nanopore sensor cells enclosed by the reservoir. Each nanopore sensor cell has a working electrode. At least one surface of the reservoir is configured to be in contact with a conducting fluid when the conducting fluid is flowing through the reservoir. The chip package further includes a counter electrode disposed on the at least one surface of the reservoir.

Abstract translation: 公开了一种基于纳米孔的测序芯片封装。 基于纳基的测序芯片封装包括由多个表面限定的储存器。 芯片封装包括纳米孔单元阵列，其包括由储存器封闭的多个纳米孔传感器单元。 每个纳米孔传感器单元具有工作电极。 当导电流体流过储存器时，储存器的至少一个表面被配置为与导电流体接触。 芯片封装还包括设置在储存器的至少一个表面上的对电极。