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    Nanopore-based sequencing with varying voltage stimulus
    4.
    发明授权
    Nanopore-based sequencing with varying voltage stimulus 有权
    具有不同电压刺激的基于纳米孔的测序

    公开(公告)号：US09557294B2

    公开(公告)日：2017-01-31

    申请号：US14577511

    申请日：2014-12-19

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J. A. Chen ,  Hui Tian ,  Bill Maney

    IPC: G01N27/447 ,  B01L3/00 ,  C12Q1/68 ,  G01N33/487

    CPC classification number: G01N27/44791 ,  B01L3/50273 ,  B01L2400/0421 ,  C12Q1/6869 ,  G01N27/44743 ,  G01N33/48721 ,  C12Q2565/607 ,  C12Q2565/631

    Abstract: A method of analyzing a molecule in a nanopore is disclosed. A voltage is applied across a nanopore that is inserted in a membrane by coupling the nanopore to a voltage source. The nanopore is decoupled from the voltage source. After the decoupling, a rate of decay of the voltage across the nanopore is determined. A molecule in the nanopore is distinguished from other possible molecules based on the determined rate of decay of the voltage across the nanopore.

    Abstract translation: 公开了分析纳米孔中分子的方法。 通过将纳米孔耦合到电压源，跨越插入膜中的纳米孔施加电压。 纳米孔与电压源分离。 在解耦之后，确定纳米孔上电压的衰减速率。 基于确定的纳米孔上的电压衰减速率，纳米孔中的分子与其它可能的分子区分开来。

    DIFFERENTIAL OUTPUT OF ANALOG MEMORIES STORING NANOPORE MEASUREMENT SAMPLES
    5.
    发明申请
    DIFFERENTIAL OUTPUT OF ANALOG MEMORIES STORING NANOPORE MEASUREMENT SAMPLES 审中-公开

    公开(公告)号：US20190025238A1

    公开(公告)日：2019-01-24

    申请号：US16141658

    申请日：2018-09-25

    Applicant: Genia Technologies, Inc.

    Inventor： Bill Maney ,  Hui Tian ,  Santiago Fernandez-Gomez

    IPC: G01N27/26 ,  G01N33/487 ,  B82Y35/00

    Abstract: A nanopore measurement circuit includes a first analog memory configured to store a first electrical value corresponding to a first measurement sample of a nanopore and a second analog memory configured to store a second electrical value corresponding to a second measurement sample of the nanopore. The nanopore measurement circuit also includes a measurement circuitry configured to provide an output indicating a difference between the first electrical value of the first analog memory and the second electrical value of the second analog memory.

    NANOPORE-BASED SEQUENCING WITH VARYING VOLTAGE STIMULUS
    6.
    发明申请
    NANOPORE-BASED SEQUENCING WITH VARYING VOLTAGE STIMULUS 有权
    基于纳米级的测量与变化的电压STIMULUS

    公开(公告)号：US20160178554A1

    公开(公告)日：2016-06-23

    申请号：US14971667

    申请日：2015-12-16

    Applicant: Genia Technologies, Inc.

    Inventor： Roger J.A. Chen ,  Hui Tian ,  Bill Maney

    IPC: G01N27/22 ,  C12Q1/68 ,  G01N33/487 ,  G01N27/447

    CPC classification number: G01N27/228 ,  C12Q1/6869 ,  G01N27/3273 ,  G01N27/44791 ,  G01N33/48721 ,  C12Q2527/125 ,  C12Q2565/607 ,  C12Q2565/629 ,  C12Q2565/631

    Abstract: A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.

    Abstract translation: 公开了分析分子的方法。 使用由复位信号控制的开关，电压源选择性地连接到电容器或从电容器断开。 当电压源连接到电容器时，电容被存储在电容器中。 当电压源与电容器断开时，电容器通过膜中的纳米孔排出。 确定复位信号的占空比，使得电压源和电容器连接至复位信号周期的至少十分之一，并且对于复位信号周期的剩余部分断开，使得跨越纳米孔的电压 在维持连接的复位信号周期的部分期间保持在比不保持连接的复位信号周期的剩余部分期间更高的电平。

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