公开(公告)号：US20140303356A1

公开(公告)日：2014-10-09

申请号：US14353962

申请日：2012-10-26

Applicant: GENMAB A/S

Inventor： Michael Gramer ,  Amitava Kundu ,  Ewald T. J. Van Den Bremer ,  Muriel Van Kamper ,  Patrick Priem ,  Aran Frank Labrijn ,  Joyce I. Meesters ,  Joost J. Neijssen ,  Janine Schuurman ,  Paul Parren ,  Patrick Van Berkel ,  Werner L. Vos ,  Arnout Gerritsen

IPC: C07K1/113 ,  C07K16/46

CPC classification number: C07K1/1133 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/90

Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.

Abstract translation: 本发明涉及用于生产异二聚体蛋白质的体外方法。

公开(公告)号：US11578141B2

公开(公告)日：2023-02-14

申请号：US16667369

申请日：2019-10-29

Applicant: GENMAB A/S

Inventor： Joost J. Neijssen ,  Joyce I. Meesters ,  Bart De Goeij ,  Aran Frank Labrijn ,  Paul Parren ,  Janine Schuurman

IPC: C07K16/46 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K39/395 ,  C07K1/113 ,  A61K39/00

Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.

公开(公告)号：US11512140B2

公开(公告)日：2022-11-29

申请号：US16548883

申请日：2019-08-23

Applicant: GENMAB A/S

Inventor： Joost J. Neijssen ,  Bart De Goeij ,  Edward Norbert Van Den Brink ,  Aran Frank Labrijn ,  Rene Hoet ,  Janine Schuurman ,  Paul Parren ,  Jan Van De Winkel

IPC: C07K16/30 ,  G01N33/574 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  C07K16/40 ,  A61K39/00

Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US11485796B2

公开(公告)日：2022-11-01

申请号：US16783720

申请日：2020-02-06

Applicant: GENMAB A/S

Inventor： Aran Frank Labrijn ,  Joyce I. Meesters ,  Joost J. Neijssen ,  Edward Norbert Van Den Brink ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/00 ,  C07K16/40 ,  C07K16/28 ,  C07K16/10 ,  C07K16/36 ,  C07K16/32 ,  C07K16/12 ,  A61K39/00

Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.