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公开(公告)号：US5811523A
公开(公告)日：1998-09-22
申请号：US956240
申请日：1997-10-22
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
CPC分类号： C07K14/5434 , C07K14/52 , A61K38/00
摘要： A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
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公开(公告)号：US06555658B2
公开(公告)日：2003-04-29
申请号：US09924703
申请日：2001-08-09
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译： 本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。
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公开(公告)号：US06300478B1
公开(公告)日：2001-10-09
申请号：US09325958
申请日：1999-06-04
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： Antibodies reactive with a novel homogeneous human cytokine, Natural Killer Stimulatory Factor, (NKSF), NKSF having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译： 与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子，天然杀伤刺激因子（NKSF），NKSF反应的抗体以及含有该抗体的药物制剂。
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公开(公告)号：US06251957B1
公开(公告)日：2001-06-26
申请号：US08894488
申请日：1997-08-22
申请人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
发明人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
IPC分类号： A01N4304
CPC分类号： A61K35/761 , A61K31/00 , A61K38/208 , A61K38/217 , A61K39/395 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/10332 , C12N2710/10343 , Y10S514/885 , A61K2300/00
摘要： A method of reducing immune response to a viral vector containing a selected transgene is provided. The method involves co-administration of the viral vector and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.
摘要翻译： 提供了减少对含有所选转基因的病毒载体的免疫应答的方法。 该方法包括在重复给药时共同给予病毒载体和能够抑制中和抗体形成和/或CTL消除的选择的免疫调节剂。
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公开(公告)号：US06168923A
公开(公告)日：2001-01-02
申请号：US09260173
申请日：1999-03-01
申请人： Phillip Scott , Giorgio Trinchieri
发明人： Phillip Scott , Giorgio Trinchieri
IPC分类号： C12Q168
CPC分类号： A61K39/39 , A61K38/208 , A61K39/0011 , A61K39/008 , A61K2039/55516 , A61K2039/55538 , A61K2039/57 , C07K16/2818 , C07K2317/74 , Y02A50/383 , Y02A50/388 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/466 , A61K38/20 , A61K2300/00
摘要： Improved vaccine compositions and methods of making same are provided, which vaccines are characterized by an antigen from a pathogen and an effective adjuvanting amount of Interleukin-12. These IL-12 adjuvanted vaccines are capable of increasing the vaccinated host's cell mediated immune response to provide an increased and protective immune response to the pathogen. Also disclosed are methods for vaccinating hosts by administering a vaccine containing an antigen from a pathogenic microorganism and co-administering an adjuvanting amount of IL-12. Vaccines or therapeutic compositions directed against a cancer may also be adjuvanted with IL-12 according to this invention.
摘要翻译： 提供了改进的疫苗组合物及其制备方法，这些疫苗的特征在于来自病原体的抗原和有效佐剂量的白细胞介素-12。 这些IL-12佐剂疫苗能够增加接种宿主的细胞介导的免疫应答，从而为病原体提供增加的和保护性的免疫应答。 还公开了通过从病原微生物施用含有抗原的疫苗并共同施用佐剂量的IL-12来接种宿主的方法。 针对癌症的疫苗或治疗组合物也可以用根据本发明的IL-12佐剂化。
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16.发明授权Peptide-based inhibitor of interleukin-10 or interferon-gamma signaling 有权基于肽的白细胞介素-10或干扰素-γ信号传导抑制剂公开(公告)号：US09475839B2
公开(公告)日：2016-10-25
申请号：US13697259
申请日：2011-05-11
申请人： Nadya I. Tarasova , Giorgio Trinchieri , Howard A. Young , C. Andrew Stewart , Marco A. Cardone , Alan O. Perantoni
发明人： Nadya I. Tarasova , Giorgio Trinchieri , Howard A. Young , C. Andrew Stewart , Marco A. Cardone , Alan O. Perantoni
IPC分类号： C07K7/08 , C07K14/00 , C07K7/06 , C07K14/47 , C07K14/715
CPC分类号： C07K7/08 , C07K7/06 , C07K14/001 , C07K14/4703 , C07K14/7155 , C07K14/7156
摘要： A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and compositions, as well as methods for the use thereof to inhibit cytokine signaling.
摘要翻译： 包含基于IL10或IFN-γ受体序列的保守区的氨基酸序列以及相关化合物和组合物的肽或肽模拟物，以及其用于抑制细胞因子信号传导的方法。
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公开(公告)号：US06372208B1
公开(公告)日：2002-04-16
申请号：US09407490
申请日：1999-09-28
申请人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
发明人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
IPC分类号： A61K4800
CPC分类号： C12N15/86 , A61K39/39541 , A61K48/00 , A61K2039/505 , C07K16/2812 , C07K16/2875 , C12N2710/10343 , A61K2300/00
摘要： A method of reducing immune response to a viral vector containing a selected transgene is provided. The method involves co-administration of the viral vector and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.
摘要翻译： 提供了减少对含有所选转基因的病毒载体的免疫应答的方法。 该方法包括在重复给药时共同给予病毒载体和能够抑制中和抗体形成和/或CTL消除的选择的免疫调节剂。
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18.发明授权
公开(公告)号：US6086876A
公开(公告)日：2000-07-11
申请号：US19862
申请日：1998-02-06
CPC分类号： C07K16/2845 , A61K38/162 , A61K38/1725 , C07K16/2896 , A61K2039/505 , A61K39/00 , A61K48/00
摘要： The invention includes compositions and methods for selective suppression of IL-12 production in a cell. Methods of treating a human having a disease associated with dysregulated IL-12 production are also provided.
摘要翻译： 本发明包括用于选择性抑制细胞中IL-12产生的组合物和方法。 还提供了治疗与失调的IL-12产生相关疾病的人的方法。
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公开(公告)号：US5976539A
公开(公告)日：1999-11-02
申请号：US965688
申请日：1997-11-06
申请人： Phillip Scott , Giorgio Trinchieri
发明人： Phillip Scott , Giorgio Trinchieri
IPC分类号： A61K35/14 , A61K38/00 , A61K38/20 , A61K39/00 , A61K39/008 , A61K39/295 , A61K39/39 , A61P37/04 , C07K16/28 , A61K39/38 , A61K39/21 , A61K39/02
CPC分类号： A61K39/39 , A61K38/208 , A61K39/0011 , A61K39/008 , C07K16/2818 , A61K2039/55516 , A61K2039/55538 , A61K2039/57 , C07K2317/74
摘要： Improved vaccine compositions and methods of making same are provided, which vaccines are characterized by an antigen from a pathogen and an effective adjuvanting amount of Interleukin-12. These IL-12 adjuvanted vaccines are capable of increasing the vaccinated host's cell mediated immune response to provide an increased and protective immune response to the pathogen. Also disclosed are methods for vaccinating hosts by administering a vaccine containing an antigen from a pathogenic microorganism and co-administering an adjuvanting amount of IL-12. Vaccines or therapeutic compositions directed against a cancer may also be adjuvanted with IL-12 according to this invention.
摘要翻译： 提供了改进的疫苗组合物及其制备方法，这些疫苗的特征在于来自病原体的抗原和有效佐剂量的白细胞介素-12。 这些IL-12佐剂疫苗能够增加接种宿主的细胞介导的免疫应答，从而为病原体提供增加的和保护性的免疫应答。 还公开了通过从病原微生物施用含有抗原的疫苗并共同施用佐剂量的IL-12来接种宿主的方法。 针对癌症的疫苗或治疗组合物也可以用根据本发明的IL-12佐剂化。
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公开(公告)号：US5872154A
公开(公告)日：1999-02-16
申请号：US394032
申请日：1995-02-24
申请人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
发明人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
IPC分类号： A61K35/76 , A61K35/761 , A61K38/20 , A61K38/21 , A61K39/395 , A61K48/00 , C12N15/861 , A61K38/00 , A61K39/235
CPC分类号： C12N15/86 , A61K35/761 , A61K38/208 , A61K38/217 , A61K39/395 , A61K48/00 , C12N7/00 , C12N2710/10332 , C12N2710/10343
摘要： A method of reducing an immune response to a recombinant adenovirus which involves co-administration of the recombinant adenovirus and a selected immune modulator. The immune modulator functions by inhibiting the formation of neutralizing antibodies and/or reducing CTL killing of the virally infected cells. The method additionally encompasses the step of re-administering the recombinant adenovirus.
摘要翻译： 一种降低对重组腺病毒的免疫应答的方法，其涉及共同给予重组腺病毒和选定的免疫调节剂。 免疫调节剂通过抑制中和抗体的形成和/或减少病毒感染细胞的CTL杀伤而起作用。 该方法还包括重新施用重组腺病毒的步骤。
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