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    Methods of identifying patients having an altered immune status
    4.
    发明授权
    Methods of identifying patients having an altered immune status 失效
    识别具有改变的免疫状态的患者的方法

    公开(公告)号：US5965366A

    公开(公告)日：1999-10-12

    申请号：US880671

    申请日：1997-06-23

    申请人： Augusto C. Ochoa ,  Howard A. Young ,  Dan L. Longo ,  Paritosh Ghosh

    发明人： Augusto C. Ochoa ,  Howard A. Young ,  Dan L. Longo ,  Paritosh Ghosh

    IPC分类号： G01N33/53 ,  C12Q1/02 ,  C12Q1/24 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/564 ,  G01N33/569 ,  G01N33/68

    CPC分类号： G01N33/68 ,  G01N33/5091 ,  G06F19/3431

    摘要： Methods of identifying a patient having an altered immune status involve determining an immune status index for the patient and comparing it to the immune status index in healthy individuals. In general, an immune status index is the ratio of the amount of a protein that varies significantly in a patient with an altered immune status to the amount of another protein that is substantially invariant in both healthy and immune-altered individuals. Variable proteins can be TCR subunit proteins, T lymphocyte signal transduction pathway proteins, polynucleotide binding proteins or biological response modifiers (BRM). In addition, the ratio of a TH-1-type BRM to a TH-2-type BRM, the ratio of cytoplasmic to nuclear levels of polynucleotide binding proteins, the pattern of protein binding to an oligonucleotide probe that comprises the protein binding region of a gene for a BRM, or the pattern of distribution of T lymphocytes in a density gradient following density gradient centrifugation are also suitable as an immune status index. The methods are useful in identifying patients exhibiting immunosuppression, hyperimmunity and autoimmunity, as well as in assessing the immune status of a patient undergoing organ transplant.

    摘要翻译： 识别具有改变的免疫状态的患者的方法包括确定患者的免疫状态指数并将其与健康个体的免疫状态指数进行比较。 通常，免疫状态指数是在具有改变的免疫状态的患者中显着变化的蛋白质的量与健康和免疫改变个体中基本上不变的另一蛋白质的量的比率。 可变蛋白可以是TCR亚基蛋白，T淋巴细胞信号转导通路蛋白，多核苷酸结合蛋白或生物反应调节剂（BRM）。 此外，TH-1型BRM与TH-2型BRM的比例，多核苷酸结合蛋白质的细胞质与核水平的比例，蛋白质与寡核苷酸探针结合的模式，其包含蛋白质结合区域 用于BRM的基因或密度梯度离心后的密度梯度中T淋巴细胞的分布模式也适合作为免疫状态指数。 该方法可用于鉴定表现出免疫抑制，超免疫和自身免疫的患者以及评估接受器官移植的患者的免疫状态。

    Methods of identifying patients having an altered immune status
    6.
    发明授权
    Methods of identifying patients having an altered immune status 失效
    识别具有改变的免疫状态的患者的方法

    公开(公告)号：US5658744A

    公开(公告)日：1997-08-19

    申请号：US277299

    申请日：1994-07-22

    申请人： Augusto C. Ochoa ,  Howard A. Young ,  Dan L. Longo ,  Paritosh Ghosh ,  Richard Robb ,  Mary Neville

    发明人： Augusto C. Ochoa ,  Howard A. Young ,  Dan L. Longo ,  Paritosh Ghosh ,  Richard Robb ,  Mary Neville

    IPC分类号： G01N33/53 ,  C12Q1/02 ,  C12Q1/24 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/564 ,  G01N33/569 ,  G01N33/68

    CPC分类号： G01N33/68 ,  G01N33/5091 ,  G06F19/3431

    摘要： Methods of identifying a patient having an altered immune status involve determining an immune status index for the patient and comparing it to the immune status index in healthy individuals. In general, an immune status index is the ratio of the amount of a protein that varies significantly in a patient with an altered immune status to the amount of another protein that is substantially invariant in both healthy and immune-altered individuals. Variable proteins can be TCR subunit proteins, T lymphocyte signal transduction pathway proteins, polynucleotide binding proteins or biological response modifiers (BRM). In addition, the ratio of a TH-1-type BRM to a TH-2-type BRM, the ratio of cytoplasmic to nuclear levels of polynucleotide binding proteins, the pattern of protein binding to an oligonucleotide probe that comprises the protein binding region of a gene for a BRM, or the pattern of distribution of T lymphocytes in a density gradient following density gradient centrifugation are also suitable as an immune status index. The methods are useful in identifying patients exhibiting immunosuppression, hyperimmunity and autoimmunity, as well as in assessing the immune status of a patient undergoing organ transplant.

    摘要翻译： 识别具有改变的免疫状态的患者的方法包括确定患者的免疫状态指数并将其与健康个体的免疫状态指数进行比较。 通常，免疫状态指数是在具有改变的免疫状态的患者中显着变化的蛋白质的量与健康和免疫改变个体中基本上不变的另一蛋白质的量的比率。 可变蛋白可以是TCR亚基蛋白，T淋巴细胞信号转导通路蛋白，多核苷酸结合蛋白或生物反应调节剂（BRM）。 此外，TH-1型BRM与TH-2型BRM的比例，多核苷酸结合蛋白质的细胞质与核水平的比例，蛋白质与寡核苷酸探针结合的模式，其包含蛋白质结合区域 用于BRM的基因或密度梯度离心后的密度梯度中T淋巴细胞的分布模式也适合作为免疫状态指数。 该方法可用于鉴定表现出免疫抑制，超免疫和自身免疫的患者以及评估接受器官移植的患者的免疫状态。