公开(公告)号：US11691975B2

公开(公告)日：2023-07-04

申请号：US17343227

申请日：2021-06-09

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: A61K31/438 ,  A61K31/407 ,  C07D471/10

CPC classification number: C07D471/10

Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11655217B2

公开(公告)日：2023-05-23

申请号：US16615747

申请日：2018-05-22

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  John J. M. Wiener ,  Olivia D. Weber ,  Katharine K. Duncan

IPC: A61K31/496 ,  A61P25/06 ,  A61K31/5377 ,  C07D231/14 ,  A61P29/00 ,  C07D401/14 ,  C07D405/10 ,  C07D471/04 ,  C07D491/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D519/00

CPC classification number: C07D231/14 ,  A61K31/496 ,  A61K31/5377 ,  A61P25/06 ,  A61P29/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D491/08 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising the same. The compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11993588B2

公开(公告)日：2024-05-28

申请号：US17469535

申请日：2021-09-08

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Todd K. Jones ,  Kurt G. Grimm ,  Jacqueline Lorayne Blankman ,  Channing Rodney Beals

IPC: C07D403/10

CPC classification number: C07D403/10 ,  C07B2200/13

Abstract: Described herein is the MAGL inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate, including crystalline forms and pharmaceutically acceptable salts and solvates thereof.

公开(公告)号：US11434222B2

公开(公告)日：2022-09-06

申请号：US17524632

申请日：2021-11-11

Applicant: H. LUNDBECK A/S

Inventor： John J. M. Wiener ,  Cheryl A. Grice ,  Daniel J. Buzard ,  Justin S. Cisar ,  Olivia Delene Weber ,  Amy Allan ,  Nicholas Raffaele ,  Jeanne Moody ,  Michael B. Shaghafi

IPC: C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07F9/6558 ,  C07D401/14 ,  A61P25/04 ,  C07D487/04 ,  C07D471/04 ,  C07D417/12 ,  A61P25/08 ,  C07D221/20

Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.

公开(公告)号：US11273159B2

公开(公告)日：2022-03-15

申请号：US16349042

申请日：2017-11-15

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Nicole S. White ,  Joel P. Zingerman ,  Hibreniguss Terefe ,  Isaac Ghebre-Sellassie

IPC: A61K31/497 ,  A61K47/58 ,  A61K9/00 ,  A61K47/02 ,  A61K47/26

Abstract: Provided herein are pharmaceutical formulations comprising a monoacylglycerol lipase (MAGL) inhibitor, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

公开(公告)号：US11214557B2

公开(公告)日：2022-01-04

申请号：US16739642

申请日：2020-01-10

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D295/185 ,  C07D305/08 ,  C07D213/55 ,  C07D241/12 ,  C07D263/32 ,  C07D305/06

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11142526B2

公开(公告)日：2021-10-12

申请号：US16642717

申请日：2018-08-28

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Olivia D. Weber ,  Daniel J. Buzard ,  Michael B. Shaghafi ,  Todd K. Jones

IPC: C07D471/10 ,  C07D401/12 ,  C07D409/12 ,  C07D487/04 ,  C07D519/00 ,  A61P25/02 ,  A61P1/00 ,  A61P25/08 ,  A61P25/06

Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.