公开(公告)号：US20230420237A1

公开(公告)日：2023-12-28

申请号：US18037383

申请日：2021-09-17

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masahiro KOTANI ,  Takayuki OHMURA ,  Akira TASHIRO

IPC: H01J49/04

CPC classification number: H01J49/0418 ,  H01J49/40

Abstract: A sample support body is used for ionizing a component of a sample. The sample support body includes: a substrate; a porous layer provided on the substrate and having a front surface on a side opposite to the substrate; and a partition portion partitioning the front surface into a first region and a second region. The porous layer includes a main body layer having a plurality of holes opening to the front surface. The partition portion includes a partition groove formed on the front surface so as to pass between the first region and the second region.

公开(公告)号：US20220260528A1

公开(公告)日：2022-08-18

申请号：US17737430

申请日：2022-05-05

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takayuki OHMURA ,  Masahiro KOTANI

IPC: G01N27/62 ,  H01J49/04

Abstract: Provided is a sample support body that includes a substrate, an ionization substrate, a support, and a frame. The ionization substrate has a plurality of measurement regions for dropping a sample on second surface. A plurality of through-holes that open in a first surface and the second surface are formed at least in the measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. The frame has a wall provided on peripheral edges of the measurement regions on the second surface to separate the plurality of measurement regions when viewed in the direction in which the substrate and the ionization substrate face each other.

公开(公告)号：US20220189757A1

公开(公告)日：2022-06-16

申请号：US17442729

申请日：2020-01-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masahiro KOTANI ,  Takayuki OHMURA

IPC: H01J49/04 ,  H01J49/16

Abstract: A sample support body is a sample support body for ionization of a sample, including: a substrate having a first surface, a second surface on a side opposite to the first surface, and a plurality of through-holes opening on each of the first surface and the second surface; and a frame attached to the substrate, in which a thermal conductivity of the frame is 1.0 W/m·K or less.

公开(公告)号：US20220189752A1

公开(公告)日：2022-06-16

申请号：US17442760

申请日：2020-01-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masahiro KOTANI ,  Takayuki OHMURA ,  Daisuke SAIGUSA

IPC: H01J49/00 ,  H01J49/16

Abstract: An ionization method includes: a first process of preparing a sample support body including an electrically insulating substrate having a first surface, a second surface on a side opposite to the first surface, and a plurality of through-holes opening on each of the first surface and the second surface and an electrically insulating frame attached to the substrate; a second process of mounting a sample on a mount surface of a mount portion and mounting the sample support body on the mount surface so that the second surface is in contact with the sample; and a third process of ionizing components of the sample that have moved to the first surface side via the plurality of through-holes by irradiating the first surface with charged-droplets and sucking the ionized components.

公开(公告)号：US20210398790A1

公开(公告)日：2021-12-23

申请号：US17465173

申请日：2021-09-02

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yasuhida NAITO ,  Masahiro KOTANI ,  Takayuki OHMURA

IPC: H01J49/04 ,  G01N27/62 ,  G01N1/28 ,  G01N33/68 ,  H01J49/16 ,  H01J49/26

Abstract: A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.

公开(公告)号：US20210231610A1

公开(公告)日：2021-07-29

申请号：US17229914

申请日：2021-04-14

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takayuki OHMURA ,  Masahiro KOTANI

IPC: G01N27/62 ,  H01J49/04

Abstract: Provided is a sample support body that includes a substrate, an ionization substrate, a support, and a frame. The ionization substrate has a plurality of measurement regions for dropping a sample on second surface. A plurality of through-holes that open in a first surface and the second surface are formed at least in the measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. The frame has a wall provided on peripheral edges of the measurement regions on the second surface to separate the plurality of measurement regions when viewed in the direction in which the substrate and the ionization substrate face each other.

公开(公告)号：US20200266043A1

公开(公告)日：2020-08-20

申请号：US16647261

申请日：2018-08-06

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yasuhide NAITO ,  Masahiro KOTANI ,  Takayuki OHMURA

IPC: H01J49/04 ,  H01J49/00 ,  H01J49/16

Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; a third step of introducing a matrix solution into the plurality of through holes; and a fourth step of ionizing a component of the sample that is mixed with the matrix solution and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser light while a voltage is applied to the conductive layer.

公开(公告)号：US20250014881A1

公开(公告)日：2025-01-09

申请号：US18709584

申请日：2022-09-05

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takamasa IKEDA ,  Masahiro KOTANI ,  Takayuki OHMURA

IPC: H01J49/04 ,  H01J9/30 ,  H01J49/00

Abstract: A sample support includes a substrate including a first surface, and a second surface on a side opposite to the first surface, and including a measurement region in which a porous structure for communicating the first surface and the second surface with each other is formed. A calibration portion including a surface flush with the first surface is formed in the substrate. The water absorbability of the calibration portion is lower than the water absorbability of the measurement region.

公开(公告)号：US20230086284A1

公开(公告)日：2023-03-23

申请号：US17908001

申请日：2021-01-15

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masahiro KOTANI ,  Takayuki OHMURA ,  Akira TASHIRO

IPC: H01J49/04

Abstract: A sample support used for ionizing a component of a sample includes: a substrate having a first surface, a second surface opposite the first surface, and a plurality of through-holes that are open on the first surface and on the second surface; a conductive layer provided on at least the first surface; and a cationizing agent provided in the plurality of through-holes to cationize the component with a predetermined atom.

公开(公告)号：US20220199387A1

公开(公告)日：2022-06-23

申请号：US17439431

申请日：2020-01-23

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masahiro KOTANI ,  Takayuki OHMURA ,  Akira TASHIRO

IPC: H01J49/04

Abstract: A sample support body for ionization of a sample, including: a substrate having a first surface, a second surface on a side opposite to the first surface, and a plurality of through-holes opening on each of the first surface and the second surface; a conductive layer provided on the first surface; and a matrix crystal layer provided on at least one of the conductive layer and the second surface, in which the matrix crystal layer is formed of a plurality of matrix crystal grains so as to include a gap communicating the plurality of through-holes with an outside.