公开(公告)号：US20230141600A1

公开(公告)日：2023-05-11

申请号：US18076274

申请日：2022-12-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Christian KRAMER ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Sébastien SCHMITT ,  Theodor STOLL ,  Jianhua WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/20 ,  A61K9/48 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

CPC classification number: C07D487/04 ,  C07D519/00 ,  A61P31/04 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2009 ,  A61K9/4866 ,  A61K9/4858 ,  A61K9/485 ,  A61K9/08 ,  A61K47/12 ,  A61K47/40

Abstract: The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein:




or pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20230017532A1

公开(公告)日：2023-01-19

申请号：US17349862

申请日：2021-06-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Sebastien SCHMITT ,  Theodor STOLL ,  Jianhua WANG ,  Song YANG

IPC: C07D487/04 ,  C07D519/00

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof.
Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.

公开(公告)号：US20150299165A1

公开(公告)日：2015-10-22

申请号：US14648418

申请日：2013-12-04

Applicant: HOFFMANN-LA ROCHE INC.

Inventor： Stefanie BENDELS ,  Uwe GRETHER ,  Atsushi KIMBARA ,  Matthias NETTEKOVEN ,  Stephan ROEVER ,  Mark ROGERS-EVANS ,  Ernst SCHAFFTER ,  Tanja SCHULZ-GASCH

IPC: C07D401/04 ,  C07D401/14 ,  C07D471/10 ,  C07D405/12 ,  C07D495/08 ,  C07D495/10 ,  C07D491/107 ,  C07D413/14

CPC classification number: C07D401/04 ,  C07D213/81 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/10 ,  C07D487/08 ,  C07D491/04 ,  C07D491/08 ,  C07D491/10 ,  C07D491/107 ,  C07D495/08 ,  C07D495/10

Abstract: The invention relates to CB2 agonists of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract translation: 本发明涉及式（I）的CB 2激动剂，其中R 1至R 4如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。