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公开(公告)号:US20150299220A1
公开(公告)日:2015-10-22
申请号:US14648399
申请日:2013-12-04
Applicant: HOFFMANN-LA ROCHE INC.
Inventor: Baledi DHURWASULU , Uwe GRETHER , Matthias NETTEKOVEN , Stephan ROEVER , Mark ROGERS-EVANS , Tanja SCHULZ-GASCH
IPC: C07D498/08 , C07D403/14 , C07D417/14 , C07D413/14 , C07D491/107 , C07D403/06 , C07D403/04
CPC classification number: C07D498/08 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D491/107
Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) is a CB2 receptor agonist for use in the treatment of several disorders, such as pain, atherosclerosis and glaucoma.
Abstract translation: 本发明涉及式(I)化合物,其中R 1至R 4如说明书和权利要求中所定义。 式(I)化合物是用于治疗几种疾病如疼痛,动脉粥样硬化和青光眼的CB2受体激动剂。
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公开(公告)号:US20150344429A1
公开(公告)日:2015-12-03
申请号:US14648412
申请日:2013-12-04
Applicant: HOFFMANN-LA ROCHE INC.
Inventor: Uwe GRETHER , Atsushi KIMBARA , Matthias NETTEKOVEN , Fabienne RICKLIN , Stephan ROEVER , Mark ROGERS-EVANS , Didier ROMBACH , Tanja SCHULZ-GASCH , Matthias WESTPHAL
IPC: C07D213/81 , C07D413/14 , C07D491/107 , C07D417/14 , C07D401/04 , C07D405/12 , C07D417/12
CPC classification number: C07D213/81 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/10 , C07D491/107
Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) is a CB2 agonist and can be used as an active ingredient in a medicament.
Abstract translation: 本发明涉及式(I)化合物,其中R 1至R 4如说明书和权利要求中所定义。 式(I)化合物是CB 2激动剂,可用作药物中的活性成分。
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公开(公告)号:US20150299165A1
公开(公告)日:2015-10-22
申请号:US14648418
申请日:2013-12-04
Applicant: HOFFMANN-LA ROCHE INC.
Inventor: Stefanie BENDELS , Uwe GRETHER , Atsushi KIMBARA , Matthias NETTEKOVEN , Stephan ROEVER , Mark ROGERS-EVANS , Ernst SCHAFFTER , Tanja SCHULZ-GASCH
IPC: C07D401/04 , C07D401/14 , C07D471/10 , C07D405/12 , C07D495/08 , C07D495/10 , C07D491/107 , C07D413/14
CPC classification number: C07D401/04 , C07D213/81 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/04 , C07D491/08 , C07D491/10 , C07D491/107 , C07D495/08 , C07D495/10
Abstract: The invention relates to CB2 agonists of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Abstract translation: 本发明涉及式(I)的CB 2激动剂,其中R 1至R 4如在说明书和权利要求书中所定义。 式(I)化合物可以用作药物。
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公开(公告)号:US20180290966A1
公开(公告)日:2018-10-11
申请号:US16003385
申请日:2018-06-08
Applicant: Hoffmann-La Roche Inc.
Inventor: Olivier GAVELLE , Uwe GRETHER , Matthias NETTEKOVEN , Stephan ROEVER , Mark ROGERS-EVANS , Didier ROMBACH
IPC: C07C235/52 , C07C231/02 , C07D271/06 , C07D277/28 , C07D205/04 , C07D413/12 , C07D305/08 , C07D331/04 , C07D207/16 , C07D413/10 , C07D213/61 , C07D403/10 , C07D231/12 , C07D401/10 , C07D207/10 , C07D413/06
Abstract: The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号:US20150307452A1
公开(公告)日:2015-10-29
申请号:US14648431
申请日:2013-12-02
Applicant: HOFFMANN-LA ROCHE INC.
Inventor: Beat FREI , Luca GOBBI , Uwe GRETHER , Atsushi KIMBARA , Matthias NETTEKOVEN , Stephan ROEVER , Mark ROGERS-EVANS , Tanja SCHULZ-GASCH
IPC: C07D213/81 , C07D401/12 , C07D405/14 , C07D405/12 , C07D401/14 , C07D401/04
CPC classification number: C07D213/81 , A61P3/10 , A61P9/00 , A61P27/02 , A61P29/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Abstract translation: 本发明涉及式(I)化合物,其中R 1至R 3如在说明书和权利要求书中所定义。 式(I)化合物可以用作药物。
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