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72 条记录 (耗时 0.028 秒)

    Process for converting a solid (meth)acrylate copolymer into a dispersed form by means of a dispersing agent
    11.
    发明授权
    Process for converting a solid (meth)acrylate copolymer into a dispersed form by means of a dispersing agent 有权
    通过分散剂将固体（甲基）丙烯酸酯共聚物转化为分散形式的方法

    公开(公告)号：US09284416B2

    公开(公告)日：2016-03-15

    申请号：US13504527

    申请日：2009-11-16

    申请人： Erna Roth ,  Ruediger Alexowsky ,  Hans-Ulrich Petereit ,  Kathrin Nollenberger ,  Christian Meier

    发明人： Erna Roth ,  Ruediger Alexowsky ,  Hans-Ulrich Petereit ,  Kathrin Nollenberger ,  Christian Meier

    IPC分类号： A61K47/32 ,  C08K5/11 ,  C08K5/1535 ,  A61P11/00 ,  C08K5/41 ,  C09D105/00 ,  A61K31/522 ,  C08L5/00 ,  C08K5/06 ,  C08J3/03 ,  A61K9/50 ,  C08J3/05 ,  A61K9/28

    CPC分类号： C08J3/03 ,  A61K9/284 ,  A61K9/5026 ,  A61K9/5089 ,  C08J3/05 ,  C08J2333/14

    摘要： The present invention provides a process for converting a solid (meth)acrylate copolymer into a dispersed form by preparing an aqueous dispersion comprising the components (a) a (meth)acrylate copolymer which is composed of free-radical polymerized methyl methacrylate, ethylacrylate and a salt of 2-trimethylammoniumethyl methacrylate, present in solid form as a powder or as a granulate, (b) up to 50% by weight calculated on the (meth)acrylate copolymer (a) of a dispersing agent selected from the groups of (b) i) plasticizers in combination with emulsifiers and/or (b) ii) pharmaceutically acceptable carbohydrates having 6 to 18 carbon atoms with a functional group and (c) water by mixing the components (a), (b) and (c) to give a suspension which becomes an aqueous dispersion during the conversion of the solid (meth)acrylate copolymer into the dispersed form, characterized in that, the (meth)acrylate copolymer is converted into the dispersed form by means of the presence of the dispersing agent at a temperature of less than 50° C.

    摘要翻译： 本发明提供了一种将固体（甲基）丙烯酸酯共聚物转化成分散形式的方法，其中制备含有（a）（甲基）丙烯酸酯共聚物的组分的水性分散体，该组分由自由基聚合的甲基丙烯酸甲酯，丙烯酸乙酯和 以甲基丙烯酸2-三甲基铵乙酯为盐，粉末形式为固体形式，或以颗粒形式存在，（b）按（b）所示的分散剂的（甲基）丙烯酸酯共聚物（a）计算的至多50重量％ ）i）与乳化剂组合的增塑剂和/或（b）ii）具有官能团的具有6至18个碳原子的药学上可接受的碳水化合物和（c）通过将组分（a），（b）和（c） 得到在将固体（甲基）丙烯酸酯共聚物转化成分散形式时成为水分散体的悬浮液，其特征在于，通过存在分散体将（甲基）丙烯酸酯共聚物转化为分散形式 g试剂在低于50℃的温度下

    Granulate or powder for producing coating or binding agents for medicaments
    14.
    发明申请
    Granulate or powder for producing coating or binding agents for medicaments 有权
    用于生产药物的涂层或粘合剂的颗粒或粉末

    公开(公告)号：US20050197434A9

    公开(公告)日：2005-09-08

    申请号：US10489856

    申请日：2003-07-08

    申请人： Hans-Ulrich Petereit ,  Christian Meier ,  Erna Roth ,  Andreas Gryczke

    发明人： Hans-Ulrich Petereit ,  Christian Meier ,  Erna Roth ,  Andreas Gryczke

    IPC分类号： A61K9/16 ,  A61K9/28 ,  A61K9/50 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  B29C39/14 ,  C08J3/00 ,  C08J5/00 ,  C08K5/04

    CPC分类号： A61K9/1694 ,  A61K9/1635 ,  A61K9/1682 ,  A61K9/2846 ,  A61K9/5026

    摘要： The invention relates to a process for the production of granules or powders, suitable as coating agents and binders for oral or dermal pharmaceutical forms, for cosmetics or food supplements, consisting essentially of (a) a copolymer, consisting of free radical- polymerized C1- to C4-esters of acrylic or methacrylic acid and further (meth)acrylate monomers which contain functional tertiary amino groups, (b) 3 to 25% by weight, based on (a), of an emulsifier having an HLB of at least 14, (c) 5 to 50% by weight, based on (a), of a C12- to C18-monocarboxylic acid or of a C12- to C18- hydroxyl compound, where the components (a), (b) and (c) are simultaneously or successively blended or mixed with one another, optionally with addition of a pharmaceutical active compound and/or further customary additives, fused in a heatable mixer, mixed, the melt is cooled and comminuted to give granules or powders.

    摘要翻译： 本发明涉及一种用于生产用于化妆品或食品补充剂的适合作为口服或皮肤药物形式的包衣剂和粘合剂的颗粒或粉末的方法，其基本上由（a）共聚物组成，所述共聚物由游离基聚合的C1- 丙烯酸或甲基丙烯酸的C 4 - 酯和另外（甲基）丙烯酸酯单体，其中含有官能叔氨基，（b）3-25重量％，基于（a）的HLB为至少14的乳化剂， （c）5至50重量％，基于（a），C 12 - 12 - C 18 - 单羧酸或C 12 - 其中组分（a），（b）和（c）同时或相继地彼此混合或混合，任选地加入药物活性物质 化合物和/或其它常规添加剂，在可加热混合器中熔融混合，将熔体冷却并粉碎以产生颗粒或粉末。

    Method for producing an immediately decomposing oral form of administration which releases active ingredients
    16.
    发明授权
    Method for producing an immediately decomposing oral form of administration which releases active ingredients 有权

    公开(公告)号：US08343542B2

    公开(公告)日：2013-01-01

    申请号：US10542283

    申请日：2003-11-21

    申请人： Hans-Ulrich Petereit ,  Christian Meier ,  Andreas Gryczke

    发明人： Hans-Ulrich Petereit ,  Christian Meier ,  Andreas Gryczke

    IPC分类号： A61K9/20 ,  B27N3/00

    CPC分类号： A61J3/10 ,  A61K9/0056 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/2054 ,  A61K31/192

    摘要： The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 μm or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.

    pH-sensitive polymer
    18.
    发明授权
    pH-sensitive polymer 有权
    pH敏感聚合物

    公开(公告)号：US07553918B2

    公开(公告)日：2009-06-30

    申请号：US10510371

    申请日：2002-10-22

    申请人： Hans-Ulrich Petereit ,  Christian Meier ,  Klaus Schultes ,  Marie-Andree Yessine ,  Jean-Christophe Leroux

    发明人： Hans-Ulrich Petereit ,  Christian Meier ,  Klaus Schultes ,  Marie-Andree Yessine ,  Jean-Christophe Leroux

    IPC分类号： C08F20/06

    CPC分类号： A61K9/0019 ,  A61K9/0014 ,  A61K47/32

    摘要： The invention relates to a pH-sensitive polymer which is a (meth)acrylate copolymer composed of 20 to 65% by weight acrylic and/or methacrylic acid units and 80 to 35% by weight units of C1- to C18-alkyl esters of (meth)acrylic acid, characterized in that it has a molecular weight in the range from 1 000 to 50 000 g/mol, and brings about at least 60% haemolysis at pH 5.5, and less than 5% haemolysis at pH 7.4, in a concentration of 150 μg/ml in a cytotoxicity test with human red blood cells. The invention further relates to the use of the pH-sensitive polymer as carrier for pharmaceutically effective biomolecules or active pharmaceutical ingredients and as ingredient of corresponding dosage forms.

    摘要翻译： 本发明涉及一种pH敏感性聚合物，它是由20-65％（重量）丙烯酸和/或甲基丙烯酸单元组成的（甲基）丙烯酸酯共聚物和80-35％（重量）单元的C 1 -C 18烷基酯（ 甲基）丙烯酸，其特征在于其分子量在1000至500000克/摩尔的范围内，并且在pH7.5下产生至少60％的溶血，并且在pH7.4时溶血小于5％，在 在人红细胞的细胞毒性试验中浓度为150ug / ml。 本发明还涉及pH敏感性聚合物作为药学上有效的生物分子或活性药物成分的载体和作为相应剂型的成分的用途。

    Macroporous material in the form of plastic pearls
    20.
    发明授权
    Macroporous material in the form of plastic pearls 失效
    大孔材料以塑料珠的形式

    公开(公告)号：US07381552B2

    公开(公告)日：2008-06-03

    申请号：US10498971

    申请日：2003-08-25

    申请人： Stefan Menzler ,  Hans-Ulrich Petereit ,  Christian Meier ,  Thomas Boller ,  Thomas Suefke ,  Klaus Schultes ,  Roger Recktenwald

    发明人： Stefan Menzler ,  Hans-Ulrich Petereit ,  Christian Meier ,  Thomas Boller ,  Thomas Suefke ,  Klaus Schultes ,  Roger Recktenwald

    IPC分类号： C12N11/08 ,  G01N33/545 ,  C07K17/08

    CPC分类号： C08F220/28 ,  C08F246/00 ,  Y10S530/815

    摘要： The invention relates to a macroporous plastics bead material with an average particle diameter from 10 to 1000 μm, containing a copolymer of a) 5-60 wt. % vinylically polymerizable monomers with a water solubility of at least 1% at 20° C., b) 1-40 wt. % vinylically polymerizable monomers with an additional functional group, which can enter into covalent bonds with the nucleophilic groups of the ligands in a polymer-like reaction, c) 10-40 wt. % hydrophilic, crosslinking radical-polymerizable monomers with two or more ethylenically unsaturated polymerizable groups and d) 10-60 wt. % vinylically polymerizable monomers with a water solubility of at most 1% at 20° C. are contained, as a rule with the monomers a) to d) adding up to 100%.

    摘要翻译： 本发明涉及平均粒径为10-1000μm的大孔塑料珠粒材料，其含有a）5-60wt。 ％乙烯基聚合性单体，水溶性在20℃下至少为1％，b）1-40wt。 具有另外的官能团的具有可与聚合物样反应中的配体的亲核基团共价键的乙烯基聚合性单体的％，c）10-40wt。 具有两个或更多个烯属不饱和可聚合基团的亲水性交联自由基聚合单体，和d）10-60wt。 在20℃下水溶解度最多为1％的％乙烯基聚合性单体的含量通常与单体a）至d）相加至100％。