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公开(公告)号：US07632431B2
公开(公告)日：2009-12-15
申请号：US11317154
申请日：2005-12-22
申请人： Massoud Ghazizadeh , Harish Makker
发明人： Massoud Ghazizadeh , Harish Makker
IPC分类号： B29D11/00
CPC分类号： A61F2/1678 , A61F2002/1683
摘要： An intraocular lens includes an optic adapted to focus light toward a retina of an eye, and at least one fixation member configured to at least assist in supporting the optic in the eye. The fixation member includes a proximal portion coupled to the optic and a distal portion configured to be in contact with eye tissue when the intraocular lens is in use in the eye. The proximal portion of the fixation member includes at least one first area formed of a first, substantially rigid material, and at least one second area formed of a second material which is more flexible than the first material.
摘要翻译： 眼内透镜包括适于将光聚焦到眼睛的视网膜的光学镜片，以及至少一个固定构件，其被配置为至少辅助支撑眼睛中的光学元件。 固定构件包括联接到光学元件的近端部分和当眼内透镜在眼睛中使用时构造成与眼睛组织接触的远端部分。 固定构件的近端部分包括由第一基本上刚性的材料形成的至少一个第一区域和由比第一材料更柔性的第二材料形成的至少一个第二区域。
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公开(公告)号：US07687097B2
公开(公告)日：2010-03-30
申请号：US11146983
申请日：2005-06-07
申请人： Harish Makker , Can B. Hu , Michael D. Lowery
发明人： Harish Makker , Can B. Hu , Michael D. Lowery
CPC分类号： A61F2/1664 , A61F2/167 , A61F2/1675 , A61F2/1678 , Y10T428/1393
摘要： Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.
摘要翻译： 公开了用于插入眼内透镜（IOL）的装置和制造和使用装置的方法。 该装置包括具有限定中空空间的内壁的中空管，眼内透镜可以通过该中空空间从开放空间传入眼睛。 润滑性增强组分以有效促进眼内透镜通过中空空间的量在内壁处共价结合到中空管。 润滑性增强组分包括相对于没有取代基组分的相同润滑性增强组分有效减少所述润滑性增强组分的水解的取代基组分。
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公开(公告)号：US06679891B2
公开(公告)日：2004-01-20
申请号：US10077615
申请日：2002-02-15
IPC分类号： A61F900
CPC分类号： A61F2/1675 , A61F2/1664
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译： 将眼内透镜（IOL）插入到眼睛中的装置包括中空管，其包括材料并具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口，以及 润滑性增强部件物理地固定到所述中空管并且在内壁或其附近集中在有效促进IOL通过中空空间的量的量。
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公开(公告)号：US06283975B1
公开(公告)日：2001-09-04
申请号：US09370009
申请日：1999-08-06
IPC分类号： A61F900
CPC分类号： A61F2/1675
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a water soluble lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译： 用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及 水溶性润滑增强组分物理地固定到所述中空管上，并且以有效促进IOL通过中空空间的量在内壁或其附近集中。
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公开(公告)号：US07348038B2
公开(公告)日：2008-03-25
申请号：US10738561
申请日：2003-12-16
CPC分类号： A61F2/1675 , A61F2/1664
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译： 用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及 润滑性增强部件物理地固定到所述中空管上并且以有效促进IOL通过中空空间的量在内壁或其附近集中。
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公开(公告)号：US20070203502A1
公开(公告)日：2007-08-30
申请号：US11696811
申请日：2007-04-05
申请人： Harish Makker , Shih-Liang Yang , Daniel Brady , Robert Glick
发明人： Harish Makker , Shih-Liang Yang , Daniel Brady , Robert Glick
IPC分类号： A61F9/007
CPC分类号： A61F2/1675 , A61F2/1664
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译： 用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及 润滑性增强部件物理地固定到所述中空管上并且以有效促进IOL通过中空空间的量在内壁或其附近集中。
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公开(公告)号：US06398788B1
公开(公告)日：2002-06-04
申请号：US09535267
申请日：2000-03-23
IPC分类号： A61F9007
CPC分类号： A61F2/1675 , A61F2/1664
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译： 用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及 润滑性增强部件物理地固定到所述中空管上并且以有效促进IOL通过中空空间的量在内壁或其附近集中。
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公开(公告)号：US5942277A
公开(公告)日：1999-08-24
申请号：US903282
申请日：1997-07-30
CPC分类号： A61F2/1664 , Y10S623/907
摘要： Method of making an apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having a plasma exposed interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译： 制造用于将眼内透镜（IOL）插入眼睛的装置的方法包括：中空管，其包括材料并具有限定通过IOL的中空空间的等离子体暴露的内壁，以及IOL从中空穿过的出口 空间成为眼睛，以及润滑性增强部件，其物理地固定到所述中空管，并且以有效促进IOL通过中空空间的量在内壁或其附近集中。
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公开(公告)号：US5716364A
公开(公告)日：1998-02-10
申请号：US676699
申请日：1996-07-10
CPC分类号： A61F2/1664 , Y10S623/907
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes include a hollow tube including a material and having an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component physically secured to said hollow tube and concentrated at or near the interior wall in an amount effective to facilitate the passage of the IOL through the hollow space.
摘要翻译： 用于将眼内透镜（IOL）插入眼睛的装置包括：中空管，其包括材料，并且具有限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间穿过眼睛的出口;以及 润滑性增强部件物理地固定到所述中空管上并且以有效促进IOL通过中空空间的量在内壁或其附近集中。
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公开(公告)号：US08323799B2
公开(公告)日：2012-12-04
申请号：US13282239
申请日：2011-10-26
申请人： Can B Hu , Michael D Lowery , Harish Makker
发明人： Can B Hu , Michael D Lowery , Harish Makker
CPC分类号： A61F2/1675 , A61L27/34 , C08G18/0823 , C08G18/833 , C08L39/06 , C09D175/04 , Y10T428/31536 , Y10T428/31551 , Y10T428/31663 , C08L5/08 , C08L2666/04
摘要： Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.
摘要翻译： 提供用于聚合物IOL插入盒的柔软，柔性高润滑性涂层，其允许IOL容易地插入适于与小（小于3mm）切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛，而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说，使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络（IPN）。 因此，IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。
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