利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

34 条记录 (耗时 0.018 秒)

    Medical devices having soft, flexible lubricious coatings
    1.
    发明授权
    Medical devices having soft, flexible lubricious coatings 有权
    具有软，柔性润滑涂层的医疗设备

    公开(公告)号：US08323799B2

    公开(公告)日：2012-12-04

    申请号：US13282239

    申请日：2011-10-26

    申请人： Can B Hu ,  Michael D Lowery ,  Harish Makker

    发明人： Can B Hu ,  Michael D Lowery ,  Harish Makker

    IPC分类号： A61F2/16 ,  A61F9/00

    CPC分类号： A61F2/1675 ,  A61L27/34 ,  C08G18/0823 ,  C08G18/833 ,  C08L39/06 ,  C09D175/04 ,  Y10T428/31536 ,  Y10T428/31551 ,  Y10T428/31663 ,  C08L5/08 ,  C08L2666/04

    摘要： Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.

    摘要翻译： 提供用于聚合物IOL插入盒的柔软，柔性高润滑性涂层，其允许IOL容易地插入适于与小（小于3mm）切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛，而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说，使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络（IPN）。 因此，IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。

    POLYMER COMPOSITIONS SUITABLE FOR INTRAOCULAR LENSES AND RELATED METHODS
    3.
    发明申请
    POLYMER COMPOSITIONS SUITABLE FOR INTRAOCULAR LENSES AND RELATED METHODS 有权
    适用于内镜的聚合物组合物及相关方法

    公开(公告)号：US20090088839A1

    公开(公告)日：2009-04-02

    申请号：US11864450

    申请日：2007-09-28

    申请人： Can B. Hu ,  Michael D. Lowery

    发明人： Can B. Hu ,  Michael D. Lowery

    IPC分类号： A61F2/16 ,  C08G77/04

    CPC分类号： A61F2/16 ,  A61F2/15 ,  A61F2/1613 ,  A61F2002/1681 ,  A61F2002/1682 ,  A61F2250/0018 ,  A61L27/18 ,  A61L2430/16 ,  C08F230/08 ,  C08G77/20 ,  C08G77/70 ,  C08L83/04 ,  Y10T156/10

    摘要： A polymeric material with a molecular response time that makes it suitable for use near fragile body tissues. The polymeric material is useful for both low modulus and high modulus applications thereby simplifying the multi-part polymeric article manufacturing process and creating better integrated multi-part polymeric articles. Cross-linked polymers with different moduli may be obtained utilizing the same or similar starting materials but modifying the amount of catalyst, the amount of cross-linking agent, and/or the amount of methyl vinyl cyclics.

    摘要翻译： 具有分子响应时间的聚合材料，使其适合在脆弱的身体组织附近使用。 聚合物材料可用于低模量和高模量应用，从而简化了多部件聚合物制品的制造过程，并且形成了更好的集成的多部分聚合物制品。 具有不同模量的交联聚合物可以利用相同或相似的起始材料获得，但改变催化剂的量，交联剂的量和/或甲基乙烯基环状的量。

    Devices for harvesting and homogenizing adipose tissue containing autologous endothelial cells
    4.
    发明授权
    Devices for harvesting and homogenizing adipose tissue containing autologous endothelial cells 失效
    用于收获和匀浆含有自体内皮细胞的脂肪组织的装置

    公开(公告)号：US6020196A

    公开(公告)日：2000-02-01

    申请号：US36162

    申请日：1998-03-06

    申请人： Can B. Hu ,  Keith E. Myers ,  Robert C. Peterson

    发明人： Can B. Hu ,  Keith E. Myers ,  Robert C. Peterson

    IPC分类号： A61B17/20 ,  A61M1/00 ,  A61N1/30 ,  C12N5/00

    CPC分类号： A61B17/20 ,  A61M1/00 ,  A61N1/30 ,  C12N5/00 ,  Y10S435/975

    摘要： Disclosed herein are methods for harvesting adipose tissue so as to preserve an increased population of viable microvascular endothelial cells. Adipose tissue containing microvascular endothelial cells is harvested using a collection apparatus incorporating an elongate cannula having apertures with tissue cutting edges. A sub-ambient pressure is applied to a lumen in the cannula to draw the adipose tissue through the aperture where it is then severed using the cutting edge to disrupt the connective adipose matrix. This harvesting provides a cleaner, more homogeneous sample of adipose tissue, thereby increasing the population of viable microvascular endothelial cells obtained through further processing. Rapid and easy methods for the further homogenization of the harvested adipose tissue are also disclosed.

    摘要翻译： 本文公开了用于收获脂肪组织的方法，以便保持增加的活微血管内皮细胞的数量。 使用收集装置收集含有微血管内皮细胞的脂肪组织，所述收集装置包含具有带有组织切割边缘的孔的细长插管。 将副环境压力施加到套管中的内腔以通过孔将纤维组织穿过，然后使用切割边缘切断脂肪组织以破坏连接性脂肪基质。 这种收获提供了更清洁，更均匀的脂肪组织样品，从而增加了通过进一步加工获得的活微血管内皮细胞的数量。 还公开了用于进一步均化收获的脂肪组织的快速和容易的方法。

    Method of making an article having a hemocompatible surface
    5.
    发明授权
    Method of making an article having a hemocompatible surface 失效
    制备具有血液相容性表面的制品的方法

    公开(公告)号：US5059269A

    公开(公告)日：1991-10-22

    申请号：US491020

    申请日：1990-03-09

    申请人： Can B. Hu ,  Donald D. Solomon ,  Stanley C. Wells

    发明人： Can B. Hu ,  Donald D. Solomon ,  Stanley C. Wells

    IPC分类号： A61L33/06 ,  C08G18/61

    CPC分类号： C08G18/61 ,  A61L33/068

    摘要： An article has a blood-contacting hemocompatible surface layer of a urethane-siloxane copolymer on a thermoplastic polymeric base material. The copolymer has siloxane segments prepared from hydroxyalkyl terminated polysiloxane glycols. The article is prepared by coextrusion of the base material and the copolymer.

    摘要翻译： 制品在热塑性聚合物基材上具有聚氨酯 - 硅氧烷共聚物的与血液接触的血液相容性表面层。 该共聚物具有由羟烷基封端的聚硅氧烷二醇制备的硅氧烷链段。 该制品通过共挤出基材和共聚物制备。

    Intraocular Lens Insertion Devices
    7.
    发明申请
    Intraocular Lens Insertion Devices 有权
    眼内透镜插入装置

    公开(公告)号：US20110295264A1

    公开(公告)日：2011-12-01

    申请号：US12753762

    申请日：2010-04-02

    申请人： Mark S. Cole ,  Can B. Hu ,  Kevin R. Springer

    发明人： Mark S. Cole ,  Can B. Hu ,  Kevin R. Springer

    IPC分类号： A61F9/00

    CPC分类号： A61F2/1675 ,  A61F2/1662 ,  A61F2/167 ,  A61F2/1678 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10

    摘要： A cartridge for an intraocular lens insertion device is disclosed. An example cartridge may include an intraocular lens insertion cartridge body having a distal end and a proximal end and configured to receive an intraocular lens for insertion into a patient's eye through an incision; the intraocular lens insertion cartridge body having an inner surface comprising at least one polymeric material having a hardness greater than about 50 D and an elongation at break greater than about 150%; the inner surface of the intraocular lens insertion cartridge body defining an at least partially tapering insertion pathway disposed within the intraocular lens insertion cartridge body and extending from the proximal end to the distal end of the intraocular lens insertion cartridge body.

    摘要翻译： 公开了一种用于眼内透镜插入装置的盒。 示例性盒可以包括眼内透镜插入盒本体，其具有远端和近端并且被配置为接收通过切口插入患者眼睛的眼内透镜; 所述眼内透镜插入筒体具有包含至少一种硬度大于约50D且断裂伸长率大于约150％的至少一种聚合材料的内表面; 眼内透镜插入盒本体的内表面限定设置在眼内透镜插入盒本体内并从眼内透镜插入筒体的近端延伸到远端的至少部分渐缩的插入通道。

    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses
    8.
    发明授权
    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses 有权
    用于制造前房人工晶状体的生物相容性聚合物组合物

    公开(公告)号：US07247689B2

    公开(公告)日：2007-07-24

    申请号：US11219021

    申请日：2005-09-01

    申请人： Harish C. Makker ,  Michael D. Lowery ,  Can B. Hu

    发明人： Harish C. Makker ,  Michael D. Lowery ,  Can B. Hu

    IPC分类号： C08F120/22 ,  C08F20/22 ,  C08F220/22 ,  C08F18/20

    CPC分类号： A61L27/26 ,  A61L2430/16 ,  C08F220/18

    摘要： Biocompatible polymers useful for making anterior chamber intraocular lenses (AC-IOL) are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violet light absorbing dyes. The AC-IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia and astigmatisms.

    摘要翻译： 提供了可用于制备前房人工晶状体（AC-IOL）的生物相容性聚合物。 生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外光和/或蓝紫色光吸收染料。 使用本文公开的生物相容性聚合物制备的AC-IOL适于放置在晶状体或无晶状体眼睛中，并且用于屈光矫正，包括近视，远视，老花眼和散光。

    Lubricious coatings for medical devices
    9.
    发明授权
    Lubricious coatings for medical devices 有权
    用于医疗器械的润滑涂层

    公开(公告)号：US06340465B1

    公开(公告)日：2002-01-22

    申请号：US09290501

    申请日：1999-04-12

    申请人： Li-Chien Hsu ,  Can B. Hu

    发明人： Li-Chien Hsu ,  Can B. Hu

    IPC分类号： A61K900

    CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606

    摘要： Biocompatible surfaces on medical devices, particularly those formed of synthetic materials, are produced by providing coating compounds having crosslinked regions capable of entrapping biocompatible molecules on the surfaces of medical devices in order to form a stable base layer. The crosslinked base layer is lubricious and is able to function as an entrapping or coupling site for additional biocompatible agents, which agents may be stably incorporated into its crosslinked lattice. Thus, the coatings of the present invention have enhanced lubricity and may also have antimicrobial, protein-repelling, and/or antithrombotic properties. The present invention thus discloses novel, stable, biocompatible coating compositions, devices coated with the compositions of the present invention, methods of making and applying such compounds, and methods of preparing and using devices and apparatus coated with such compositions.

    摘要翻译： 医疗装置上的生物相容性表面，特别是由合成材料形成的表面，是通过提供具有交联区域的涂层化合物制成的，该交联区域能够将生物相容性分子截留在医疗装置的表面上，以便形成稳定的基底层。 交联的基层是光滑的，并且能够用作另外的生物相容剂的捕获或偶联位点，这些试剂可以稳定地并入其交联的晶格中。 因此，本发明的涂层具有增强的润滑性并且还可具有抗微生物，蛋白排斥和/或抗血栓形成性质。 因此，本发明公开了新颖的，稳定的生物相容性涂料组合物，涂有本发明组合物的装置，制备和施用这些化合物的方法，以及制备和使用涂有这些组合物的装置和装置的方法。