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11.发明授权3-cyano 5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases 有权3-氰基-5-硫杂杂环芳基 - 二氢吡啶及其用于治疗心血管疾病的用途公开(公告)号：US08404723B2
公开(公告)日：2013-03-26
申请号：US12442399
申请日：2007-09-08
IPC分类号： A61K31/4436 , C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的芳基取代的3-氰基-5-噻唑基 - 和3-氰基-5-噻二唑基-1,4-二氢吡啶，其制备方法，它们用于治疗和/或预防疾病， 以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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12.发明申请3-Cyano-5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases 有权3-氰基-5-硫杂杂环芳基 - 二氢吡啶及其用于治疗心血管疾病的用途公开(公告)号：US20100240620A1
公开(公告)日：2010-09-23
申请号：US12442399
申请日：2007-09-08
IPC分类号： A61K31/60 , C07D417/04 , A61K31/4439 , A61P5/42 , A61P9/12 , A61P9/04 , A61P9/10 , A61P13/12 , A61P1/16 , C07D417/14 , A61K31/444 , A61K31/4709
CPC分类号： C07D417/04 , C07D417/14
摘要： The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的芳基取代的3-氰基-5-噻唑基 - 和3-氰基-5-噻二唑基-1,4-二氢吡啶，其制备方法，它们用于治疗和/或预防疾病， 以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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公开(公告)号：US20080194598A1
公开(公告)日：2008-08-14
申请号：US11886289
申请日：2006-03-07
申请人： Elisabeth Woltering , Arounarith Tuch , Elke Dittrich-Wengenroth , Axel Kretschmer , Lars Barfacker , Marcus Bauser , Peter Ellinghaus , Klemens Lustig , Elisabeth Pook , Olaf Weber
发明人： Elisabeth Woltering , Arounarith Tuch , Elke Dittrich-Wengenroth , Axel Kretschmer , Lars Barfacker , Marcus Bauser , Peter Ellinghaus , Klemens Lustig , Elisabeth Pook , Olaf Weber
IPC分类号： A61K31/513 , C07D239/34 , C07D239/26 , A61K31/505 , A61P9/10
CPC分类号： C07D239/28 , C07D239/34
摘要： The present application relates to pyrimidinecarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.
摘要翻译： 本申请涉及嘧啶羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或 预防心血管疾病，特别是血脂异常和动脉硬化。
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公开(公告)号：US20070161662A1
公开(公告)日：2007-07-12
申请号：US10556437
申请日：2004-04-27
申请人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20070105876A1
公开(公告)日：2007-05-10
申请号：US10556224
申请日：2004-04-28
申请人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20060154912A1
公开(公告)日：2006-07-13
申请号：US10537623
申请日：2003-11-28
申请人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： A61K31/455 , A61K31/397 , A61K31/195 , A61K31/445
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。
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