公开(公告)号：US20070098721A1

公开(公告)日：2007-05-03

申请号：US10543841

申请日：2004-02-02

申请人： Heinz Hillen ,  Andreas Striebinger ,  Carsten Krantz ,  Achim Moeller ,  Reinhold Mueller

发明人： Heinz Hillen ,  Andreas Striebinger ,  Carsten Krantz ,  Achim Moeller ,  Reinhold Mueller

IPC分类号： A01K67/00 ,  G01N33/567 ,  C12P21/06 ,  C12P21/04 ,  A61K39/395 ,  C07K16/18

CPC分类号： C07K14/4711 ,  A61K38/1709 ,  A61K39/0007 ,  A61K2039/57 ,  C07K16/005 ,  C07K16/18 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/6896 ,  G01N2333/4709

摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.

摘要翻译： 本发明涉及淀粉样蛋白-β（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗剂 ，用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白-β（1-42）蛋白的缩写形式的寡聚物和寡聚体的衍生物，其生产和用途。