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公开(公告)号：US20100311767A1
公开(公告)日：2010-12-09
申请号：US12529331
申请日：2008-02-27
申请人： Volker Nimmrich , Stefan Barghorn , Ulrich Ebert , Heinz Hillen , Gerhard Gross , Andreas Draguhn , Claus Bruhl , Christine Grimm , Carsten Krantz
发明人： Volker Nimmrich , Stefan Barghorn , Ulrich Ebert , Heinz Hillen , Gerhard Gross , Andreas Draguhn , Claus Bruhl , Christine Grimm , Carsten Krantz
IPC分类号： A61K31/52 , A61K31/519 , A61K31/137 , A61P3/00 , A61P25/28 , A61P25/00
CPC分类号： A61K31/015 , A61K31/05 , A61K31/519 , A61K39/3955
摘要： The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an agonist of the P/Q type voltage-gated presynaptic calcium channel to said subject.
摘要翻译： 本发明涉及在有需要的受试者中治疗淀粉样变性如阿尔茨海默氏病的方法，其特征在于其包括向所述受试者施用P / Q型电压门控突触前钙通道的激动剂。
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2.发明申请Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 有权淀粉样蛋白β（1-42）寡聚体，其衍生物和抗体，其制备方法和用途公开(公告)号：US20070098721A1
公开(公告)日：2007-05-03
申请号：US10543841
申请日：2004-02-02
IPC分类号： A01K67/00 , G01N33/567 , C12P21/06 , C12P21/04 , A61K39/395 , C07K16/18
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译： 本发明涉及淀粉样蛋白-β（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗剂 ，用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白-β（1-42）蛋白的缩写形式的寡聚物和寡聚体的衍生物，其生产和用途。
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3.发明授权Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 有权淀粉样蛋白β（1-42）寡聚体，其衍生物和抗体，其制备方法和用途公开(公告)号：US09176150B2
公开(公告)日：2015-11-03
申请号：US13195533
申请日：2011-08-01
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译： 本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗 用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白（1-42）蛋白质的缩写形式的寡聚物和低聚物的衍生物，其生产和用途。
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4.发明申请AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF 有权AMYLOID BETA（1-42）低聚物，其衍生物及其抗体，其制备方法及其用途公开(公告)号：US20120034166A1
公开(公告)日：2012-02-09
申请号：US13195533
申请日：2011-08-01
IPC分类号： A61K49/00 , A61K39/00 , C12P21/06 , C12N5/16 , G01N33/566 , C12P21/00 , C40B50/06 , C07K7/08 , C07K14/00 , C07K16/18 , C07K1/00 , C07H21/04 , A61K39/395 , C40B30/00
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.
摘要翻译： 本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗 用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白（1-42）蛋白质的缩写形式的寡聚物和低聚物的衍生物，其生产和用途。
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公开(公告)号：US20110130549A1
公开(公告)日：2011-06-02
申请号：US12529467
申请日：2008-02-27
申请人： Volker Nimmrich , Stefan Barghorn , Ulrich Ebert , Heinz Hillen , Gerhard Gross , Andreas Draguhn , Claus Bruehl , Christiane Grimm , Carsten Krantz
发明人： Volker Nimmrich , Stefan Barghorn , Ulrich Ebert , Heinz Hillen , Gerhard Gross , Andreas Draguhn , Claus Bruehl , Christiane Grimm , Carsten Krantz
IPC分类号： C07K16/28 , C07D473/16 , G01N33/53
CPC分类号： A61K31/015 , A61K31/05 , A61K31/519 , A61K39/3955
摘要： The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between Aβ globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.
摘要翻译： 本发明涉及在有需要的受试者中治疗淀粉样变性如阿尔茨海默病的方法，其特征在于其包括施用A＆Bgr之间相互作用的抑制剂; 球聚体和P / Q型电压门控突触前钙通道。
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6.发明申请AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF 审中-公开AMYLOID BETA（1-42）低聚物，其衍生物及其抗体，其制备方法及其用途公开(公告)号：US20100209346A1
公开(公告)日：2010-08-19
申请号：US12559255
申请日：2009-09-14
IPC分类号： A61K49/00 , C07K14/435 , G01N33/68 , G01N33/53 , C12P21/00 , C07K16/00 , C07K14/00 , A61K38/16 , A61K39/00 , A61P25/28
CPC分类号： C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/57 , C07K16/005 , C07K16/18 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6896 , G01N2333/4709
摘要： The invention relates to neuromodulatory oligomers of the amyloid β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers and diagnostic and therapeutic agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof.
摘要翻译： 本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用寡聚物和诊断和治疗剂 ，用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。
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公开(公告)号：US08895004B2
公开(公告)日：2014-11-25
申请号：US12529467
申请日：2008-02-27
申请人： Volker Nimmrich , Stefan Barghorn , Ulrich Ebert , Heinz Hillen , Gerhard Gross , Andreas Draguhn , Claus Bruhl , Christine Grimm , Carsten Krantz
发明人： Volker Nimmrich , Stefan Barghorn , Ulrich Ebert , Heinz Hillen , Gerhard Gross , Andreas Draguhn , Claus Bruhl , Christine Grimm , Carsten Krantz
IPC分类号： A61K39/395 , A61K31/015 , A61K31/05 , A61K31/519
CPC分类号： A61K31/015 , A61K31/05 , A61K31/519 , A61K39/3955
摘要： The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between Aβ globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.
摘要翻译： 本发明涉及在有需要的受试者中治疗淀粉样变性如阿尔茨海默病的方法，其特征在于其包括施用A＆Bgr之间相互作用的抑制剂; 球聚体和P / Q型电压门控突触前钙通道。
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