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18 条记录 (耗时 0.041 秒)

    Immunostimulatory oligoribonucleotides
    16.
    发明申请
    Immunostimulatory oligoribonucleotides 有权
    免疫刺激寡核糖核苷酸

    公开(公告)号：US20070142315A1

    公开(公告)日：2007-06-21

    申请号：US11603978

    申请日：2006-11-22

    申请人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson Lipford

    发明人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson Lipford

    IPC分类号： A61K48/00 ,  A61K9/14 ,  C07H21/02

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。

    Modified oligoribonucleotide analogs with enhanced immunostimulatory activity
    17.
    发明申请
    Modified oligoribonucleotide analogs with enhanced immunostimulatory activity 审中-公开
    具有增强的免疫刺激活性的修饰的寡核糖核苷酸类似物

    公开(公告)号：US20060241076A1

    公开(公告)日：2006-10-26

    申请号：US11411975

    申请日：2006-04-26

    申请人： Eugen Uhlmann ,  Arthur Krieg ,  Grayson Lipford

    发明人： Eugen Uhlmann ,  Arthur Krieg ,  Grayson Lipford

    IPC分类号： A61K48/00

    CPC分类号： C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2310/3529

    摘要： The invention provides immunostimulatory compositions and methods for their use. In particular, the immunostimulatory compositions of the invention include RNA-like polymers that incorporate an immunostimulatory sequence motif and at least one chemical modification to confer improved stability against nuclease degradation and improved activity. Specific modifications involving phosphate linkages, nucleotide analogs, and combinations thereof are provided. Compositions of the invention optionally include an antigen and can be used to stimulate an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, or asthma. Modified oligoribonucleotide analogs of the invention are believed to stimulate Toll-like receptors TLR7 and TLR8.

    摘要翻译： 本发明提供免疫刺激组合物及其使用方法。 特别地，本发明的免疫刺激组合物包括纳入免疫刺激序列基序的RNA样聚合物和至少一种化学修饰，以提供改善的对核酸酶降解的稳定性和改善的活性。 提供了涉及磷酸键，核苷酸类似物及其组合的具体修饰。 本发明的组合物任选地包括抗原并且可以用于刺激免疫应答。 还提供了可用于治疗感染，癌症，过敏性疾病或哮喘的受试者的组合物和方法。 据信本发明的修饰的寡核糖核苷酸类似物刺激Toll样受体TLR7和TLR8。

    Immunostimulatory viral RNA oligonucleotides
    18.
    发明申请
    Immunostimulatory viral RNA oligonucleotides 审中-公开
    免疫刺激性病毒RNA寡核苷酸

    公开(公告)号：US20050256073A1

    公开(公告)日：2005-11-17

    申请号：US11061140

    申请日：2005-02-18

    申请人： Grayson Lipford ,  Alexandra Forsbach

    发明人： Grayson Lipford ,  Alexandra Forsbach

    IPC分类号： A61K31/7088 ,  A61K31/7105 ,  A61K31/7125 ,  A61K39/39 ,  A61K48/00 ,  C12N15/11 ,  C12Q1/68

    CPC分类号： A61K39/39 ,  A61K2039/55561

    摘要： Immunostimulatory sequence-specific RNA oligonucleotides corresponding to 3′ terminal sequences of single-stranded minus-sense RNA genomic RNAs are provided. Also provided are compositions and methods relating to an immunostimulatory 4-mer RNA motif provided as 5′-C/U-U-G/U-U-3′. Incorporation of this short RNA motif is sufficient to confer new and altered immunostimulatory properties in new and existing oligonucleotides, including CpG oligodeoxynucleotides. Also provided are methods for use of the immunostimulatory RNA oligonucleotides and DNA:RNA chimeric oligonucleotides of the invention to induce an immune response in vitro and in vivo, as well as to treat allergy, asthma, infection, and cancer in a subject. Single-stranded oligoribonucleotides of the invention are believed to signal through a Toll-like receptor (TLR) chosen from TLR9, TLR8, TLR7, and TLR3. The oligoribonucleotides can also be used in a method to screen for TLR antagonists.

    摘要翻译： 提供了对应于单链负义RNA基因组RNA的3'末端序列的免疫刺激序列特异性RNA寡核苷酸。 还提供了与作为5'-C / U-U-G-U-U-3'提供的免疫刺激性4聚体RNA基序相关的组合物和方法。 引入这种短RNA基序足以在新的和现有的寡核苷酸（包括CpG寡脱氧核苷酸）中赋予新的和改变的免疫刺激性质。 还提供了使用本发明的免疫刺激性RNA寡核苷酸和DNA：RNA嵌合寡核苷酸在体外和体内诱导免疫应答以及治疗受试者中的过敏，哮喘，感染和癌症的方法。 据信本发明的单链寡核糖核苷酸通过选自TLR9，TLR8，TLR7和TLR3的Toll样受体（TLR）发出信号。 寡核糖核苷酸也可用于筛选TLR拮抗剂的方法中。