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    Immunostimulatory oligoribonucleotides
    1.
    发明申请
    Immunostimulatory oligoribonucleotides 有权
    免疫刺激寡核糖核苷酸

    公开(公告)号：US20070142315A1

    公开(公告)日：2007-06-21

    申请号：US11603978

    申请日：2006-11-22

    申请人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson Lipford

    发明人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson Lipford

    IPC分类号： A61K48/00 ,  A61K9/14 ,  C07H21/02

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。

    Immunostimulatory oligoribonucleotides
    2.
    发明授权
    Immunostimulatory oligoribonucleotides 有权
    免疫刺激寡核糖核苷酸

    公开(公告)号：US08354522B2

    公开(公告)日：2013-01-15

    申请号：US13046871

    申请日：2011-03-14

    申请人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson B. Lipford

    发明人： Alexandra Forsbach ,  Jorg Vollmer ,  Grayson B. Lipford

    IPC分类号： C07H21/04 ,  C07H21/02 ,  A61K39/00 ,  A61K48/00

    CPC分类号： A61K39/39 ,  A61K31/7105 ,  A61K2039/55561 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315

    摘要： The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).

    摘要翻译： 本发明提供免疫刺激组合物和这些化合物在制备用于治疗疾病和体外用途的药物中的用途。 特别地，本发明的组合物包括掺入序列依赖性免疫刺激序列基序的免疫刺激性寡核糖核苷酸。 提供涉及磷酸键，核苷酸类似物，加合物及其组合的具体修饰。 任选地可以包括抗原的本发明的组合物可以单独使用或与其它治疗一起使用以刺激或增强免疫应答。 还提供了可用于治疗患有感染，癌症，过敏性疾病，哮喘，气道重塑或免疫缺陷的受试者的组合物和方法。 认为本发明的免疫刺激性寡核糖核苷酸可刺激Toll样受体8（TLR8）。

    Immunostimulatory nucleic acids
    6.
    发明申请
    Immunostimulatory nucleic acids 审中-公开
    免疫刺激核酸

    公开(公告)号：US20070066554A1

    公开(公告)日：2007-03-22

    申请号：US11507079

    申请日：2006-08-18

    申请人： Arthur Krieg ,  Christian Schetter ,  Jorg Vollmer

    发明人： Arthur Krieg ,  Christian Schetter ,  Jorg Vollmer

    IPC分类号： A61K48/00 ,  C12Q1/68

    CPC分类号： A61K31/7105 ,  A61K31/7088 ,  A61K31/7125 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55561

    摘要： The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.

    摘要翻译： 本发明涉及免疫刺激性核酸组合物和使用该组合物的方法。 富含T的核酸含有多T序列和/或具有大于25％的T核苷酸残基。 TG核酸具有TG二核苷酸。 富含C的核酸具有至少一个多C区和/或大于50％c核苷酸。 这些免疫刺激性核酸以与含有CpG基序的核酸类似的方式起作用。 本发明还包括优选的CpG核酸。