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    Benzoheterocyclic compounds
    13.
    发明授权
    Benzoheterocyclic compounds 失效
    苯并杂环化合物

    公开(公告)号：US5290934A

    公开(公告)日：1994-03-01

    申请号：US711273

    申请日：1991-06-04

    申请人： Hiraki Ueda ,  Hisashi Miyamoto ,  Hiroshi Yamashita ,  Hitoshi Tone

    发明人： Hiraki Ueda ,  Hisashi Miyamoto ,  Hiroshi Yamashita ,  Hitoshi Tone

    IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D409/04 ,  C07D487/04 ,  C07D491/04 ,  C07D498/06 ,  C07D215/283

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D409/04 ,  C07D487/04 ,  C07D491/04

    摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

    摘要翻译： 具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5至9元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此 可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

    Oxygen-supply-capable cooling water equipment, filtration-equipment and filtration-equipped cooling water equipment incorporated with these equipment
    17.
    发明授权
    Oxygen-supply-capable cooling water equipment, filtration-equipment and filtration-equipped cooling water equipment incorporated with these equipment 失效
    配有供氧设备的冷却水设备，过滤设备和配备有过滤设备的冷却水设备

    公开(公告)号：US07087158B2

    公开(公告)日：2006-08-08

    申请号：US10928132

    申请日：2004-08-30

    申请人： Hisashi Miyamoto ,  Akira Nakano

    发明人： Hisashi Miyamoto ,  Akira Nakano

    IPC分类号： A01K63/04

    CPC分类号： A01K63/045 ,  A01K63/042 ,  F28C1/02

    摘要： Filtration-function-equipped cooling water equipment that includes: filtration equipment connected to water-purifying, oxygen-supply-capable cooling water equipment, wherein the filtration equipment includes a filtration space for a filter, wherein the water-purifying, oxygen-supply-capable cooling water equipment comprises a cooling oxidation unit disposed inside of a tank body and comprising a honeycombed or latticed porous material, wherein the filtration-function-equipped cooling water equipment operates to enlarge a contact area between water and air when untreated water drips onto the cooling oxidation unit and flows through the cooling oxidation unit while forced air flows in a counter current against the flow of water in the cooling oxidation unit, thereby facilitating solubility of oxygen in the untreated water and augmenting a cooling capability due to evaporation provided by the water-purifying, oxygen-supply-capable cooling water equipment.

    摘要翻译： 具有过滤功能的冷却水设备，包括：与净水，供氧能力的冷却水设备连接的过滤设备，其中过滤设备包括用于过滤器的过滤空间，其中净水，供氧 - 冷却水设备包括设置在罐体内部并包括蜂窝状或网状多孔材料的冷却氧化单元，其中配备过滤功能的冷却水设备用于当未处理的水滴入到水中时扩大水和空气之间的接触面积 冷却氧化单元并流过冷却氧化单元，同时强制空气以相对于冷却氧化单元中的水流的逆流流动，从而促进氧在未处理水中的溶解度并且由于由水提供的蒸发而增加冷却能力 纯化，供氧能力的冷却水设备。

    1-Cyclopropyl-6-fl uoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives
    18.
    发明授权
    1-Cyclopropyl-6-fl uoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives 失效
    1-环丙基-6-氟-7-哌嗪基-1,4-二氢-4-氧代 - 喹啉-3-羧酸衍生物

    公开(公告)号：US4880806A

    公开(公告)日：1989-11-14

    申请号：US76890

    申请日：1987-07-23

    申请人： Hiraki Ueda ,  Hisashi Miyamoto ,  Shinji Aki ,  Tatsuya Otsuka

    发明人： Hiraki Ueda ,  Hisashi Miyamoto ,  Shinji Aki ,  Tatsuya Otsuka

    IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D487/04

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D487/04

    摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.2 is a heterocyclic group: ##STR2## in which R.sup.A is H, C.sub.1 -C.sub.6 alkyl or phenyl (C.sub.1 -C.sub.6) alkyl, R.sup.B is 2-oxo-1,3-dioxolenemethyl substituted by C.sub.1 -C.sub.6 alkyl, or C.sub.3 -C.sub.8 cycloalkyl, R.sup.C is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxycarbonyl, or phenyl(C.sub.1 -C.sub.6)alkyl, R.sup.D is H or C.sub.1 -C.sub.6 alkyl, R.sup.G is C.sub.1 -C.sub.6 alkyl, and R.sup.H is C.sub.1 -C.sub.6 alkyl, phenyl(C.sub.1 -C.sub.6)alkyl, or C.sub.1 C.sub.6 alkanoyl, and R.sup.3 is C.sub.1 -C.sub.6 alkyl, or R.sup.3 is C.sub.1 -C.sub.6 alkyl having 1 to 3 substituents selected from OH, C.sub.1 -C.sub.6 alkoxy and halogen when R.sup.2 is ##STR3## or a salt thereof, said compounds having excellent antimicrobial activity and being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

    摘要翻译： 新颖的下式的4-氧代喹啉-3-羧酸化合物：其中R 2是杂环基：其中RA是H，C 1 -C 6烷基或苯基（C 1 -C 6） C6）烷基，RB是被C1-C6烷基或C3-C8环烷基取代的2-氧代-1,3-二氧杂环戊烯甲基，RC是H，C1-C6烷基，C1-C6烷氧基羰基或苯基（C1-C6）烷基 ，RD为H或C1-C6烷基，RG为C1-C6烷基，RH为C1-C6烷基，苯基（C1-C6）烷基或C1C6烷酰基，R3为C1-C6烷基，R3为C1- 当R2为1或3个选自OH，C1-C6烷氧基和卤素的取代基时，具有1至3个取代基的C6烷基或其盐，所述具有优异抗微生物活性并可用作抗微生物剂的化合物和含有所述化合物的药物组合物 活性成分。

    Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof
    19.
    发明授权
    Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof 失效
    抗菌剂1-取代苯基-4-氧代喹啉-3-羧酸化合物及其组合物

    公开(公告)号：US4684648A

    公开(公告)日：1987-08-04

    申请号：US770080

    申请日：1985-08-28

    申请人： Hitoshi Tone ,  Hisashi Miyamoto ,  Hiraki Ueda ,  Kazuyuki Nakagawa

    发明人： Hitoshi Tone ,  Hisashi Miyamoto ,  Hiraki Ueda ,  Kazuyuki Nakagawa

    IPC分类号： C07D215/56 ,  C07D487/04 ,  A61K31/40 ,  A61K31/47 ,  C07D401/14

    CPC分类号： C07D487/04 ,  C07D215/56

    摘要： Novel 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R is hydrogen atom or fluorine atom, R.degree. is hydroxy, fluorine atom or an alkanoyloxy having 1 to 6 carbon atoms, and X.sup.1 is hydrogen atom or fluorine atom, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.

    摘要翻译： 新颖的1-取代的苯基-4-氧代喹啉-3-羧酸化合物，其结构式如下：其中R是氢原子或氟原子，R是羟基，氟原子或具有1至6个碳原子的烷酰氧基，X1 所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及包含作为活性成分的所述1-取代苯基-4-氧代喹啉-3-酮的药物组合物， 羧酸化合物或其药学上可接受的盐与药学上可接受的稀释剂或载体混合。

    Oxygen-supply-capable cooling water equipment and filtration-function-equipped cooling water equipment incorporated with these equipment
    20.
    发明申请
    Oxygen-supply-capable cooling water equipment and filtration-function-equipped cooling water equipment incorporated with these equipment 失效
    配备有供氧能力的冷却水设备和配备过滤功能的冷却水设备

    公开(公告)号：US20050029176A1

    公开(公告)日：2005-02-10

    申请号：US10928132

    申请日：2004-08-30

    申请人： Hisashi Miyamoto ,  Akira Nakano

    发明人： Hisashi Miyamoto ,  Akira Nakano

    IPC分类号： A01K63/04 ,  A01K63/06 ,  C02F1/00 ,  C02F3/04 ,  F28C1/02 ,  F28C1/10 ,  F28C1/16 ,  F28F25/04 ,  F28F25/06 ,  F28F25/08 ,  C02F3/02

    CPC分类号： A01K63/045 ,  A01K63/042 ,  F28C1/02

    摘要： Filtration-function-equipped cooling water equipment that includes: filtration equipment connected to water-purifying, oxygen-supply-capable cooling water equipment, wherein the filtration equipment includes a filtration space for a filter, wherein the water-purifying, oxygen-supply-capable cooling water equipment comprises a cooling oxidation unit disposed inside of a tank body and comprising a honeycombed or latticed porous material, wherein the filtration-function-equipped cooling water equipment operates to enlarge a contact area between water and air when untreated water drips onto the cooling oxidation unit and flows through the cooling oxidation unit while forced air flows in a counter current against the flow of water in the cooling oxidation unit, thereby facilitating solubility of oxygen in the untreated water and augmenting a cooling capability due to evaporation provided by the water-purifying, oxygen-supply-capable cooling water equipment.

    摘要翻译： 具有过滤功能的冷却水设备，包括：与净水，供氧能力的冷却水设备连接的过滤设备，其中过滤设备包括用于过滤器的过滤空间，其中净水，供氧 - 冷却水设备包括设置在罐体内部并包括蜂窝状或网状多孔材料的冷却氧化单元，其中配备过滤功能的冷却水设备用于当未处理的水滴入到水中时扩大水和空气之间的接触面积 冷却氧化单元并流过冷却氧化单元，同时强制空气以相对于冷却氧化单元中的水流的逆流流动，从而促进氧在未处理水中的溶解度并且由于由水提供的蒸发而增加冷却能力 纯化，供氧能力的冷却水设备。