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    THERAPEUTIC USE OF PLEUROMUTILINS
    1.
    发明公开
    THERAPEUTIC USE OF PLEUROMUTILINS 审中-公开

    公开(公告)号：US20230174472A1

    公开(公告)日：2023-06-08

    申请号：US17919200

    申请日：2021-04-16

    申请人： NABRIVA THERAPEUTICS GMBH

    发明人： Michael Hafner ,  Susanne Paukner ,  Wolfgang Wicha ,  Rosemarie Riedl ,  Zrinka Ivezic-Schoenfeld

    IPC分类号： C07C321/16 ,  A61P11/00 ,  A61P31/16 ,  A61P29/00

    CPC分类号： C07C321/16 ,  A61P11/00 ,  A61P31/16 ,  A61P29/00

    摘要： A compound of formula (I)






    wherein
    n is 0 to 4;
    m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2′, and if m=1 then R3 is on position 1′);
    R is ethyl or vinyl;
    R1 is hydrogen or (C1-6)alkyl,
    R2 is hydrogen or

    (C3-6)cycloalkyl, or
    unsubstituted (C1-6)alkyl, or
    (C1-6)alkyl substituted by one or more of

    hydroxy; preferably one or two,
    methoxy,
    halogen,
    (C3-6)cycloalkyl, or








    R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom e. g. selected from N or O, or



    R1 is hydroxy and R2 is formyl;
    R3 is OH, OR4, a halogen atom, or
    R3 is bound to 2′ and represents —O—(CH2)p—O— with p is 2 or 3;
    R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl,
    or a pharmaceutically acceptable salt, solvate, prodrug or metabolite thereof




    for the specific use in the treatment or prevention of an inflammatory disease which is not mediated by bacteria.

    Surfactants and hydrophilic colloid compositions and materials
    5.
    发明授权
    Surfactants and hydrophilic colloid compositions and materials 失效
    表面活性剂和亲水胶体组合物和材料

    公开(公告)号：US5952521A

    公开(公告)日：1999-09-14

    申请号：US996414

    申请日：1997-12-22

    申请人： Alan Robert Pitt ,  Trevor John Wear ,  Danuta Gibson

    发明人： Alan Robert Pitt ,  Trevor John Wear ,  Danuta Gibson

    IPC分类号： C07C309/17 ,  G03C1/38 ,  G03C7/388 ,  C07C321/16 ,  C07C69/74

    CPC分类号： C07C309/17 ,  G03C1/38 ,  G03C7/388 ,  Y10S516/04 ,  Y10S516/902

    摘要： Surfactants useful as dispersing aids in the preparation of compositions comprising a hydrophilic colloid having hydrophobic particles dispersed therein have the structure ##STR1## wherein M is a cation; X represents a group having the structure ##STR2## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents hydrogen or alkyl; or R.sup.1 and R.sup.2 taken together represent cycloalkyl; or R.sup.3 and R.sup.4 taken together represent cycloalkyl; and, n represents 0 or 1; provided that the total number of carbon atoms in each X group is 3 or 4, and when R.sup.1 is hydrogen R.sup.2 is other than methyl. Such surfactants offer coating and photographic property advantages when incorporated in multilayer photographic materials comprising a support bearing a plurality of hydrophilic colloid layers.

    摘要翻译： 用作制备包含疏水颗粒分散在其中的亲水胶体的组合物的分散助剂的表面活性剂具有其中M是阳离子的结构; X表示具有以下结构的基团，其中R 1，R 2，R 3和R 4各自独立地表示氢或烷基; 或者R 1和R 2一起代表环烷基; 或者R 3和R 4一起代表环烷基; 和n表示0或1; 条件是每个X基团中的碳原子总数为3或4，并且当R 1为氢时，R 2不是甲基。 这种表面活性剂当掺入含有多个亲水胶体层的载体的多层照相材料中时，具有涂层和照相性能优点。

    SYNTHESIS OF CYCLOPHANES FOR A SELF-ASSEMBLY REACTION
    10.
    发明申请
    SYNTHESIS OF CYCLOPHANES FOR A SELF-ASSEMBLY REACTION 审中-公开

    公开(公告)号：US20170369456A1

    公开(公告)日：2017-12-28

    申请号：US15698284

    申请日：2017-09-07

    申请人： University of Oregon

    发明人： Darren W. Johnson ,  Mary Collins

    IPC分类号： C07D251/24 ,  C07C321/16 ,  C07D341/00 ,  C07D495/22

    CPC分类号： C07D251/24 ,  C07C321/16 ,  C07D341/00 ,  C07D495/22

    摘要： Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method.