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    Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds
    1.
    发明授权
    Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds 失效
    抗菌性1-取代苯基-4-氧代喹啉-3-羧酸化合物

    公开(公告)号：US4755513A

    公开(公告)日：1988-07-05

    申请号：US766337

    申请日：1985-08-16

    申请人： Hitoshi Tone ,  Hisashi Miyamoto ,  Hiraki Ueda ,  Kazuyuki Nakagawa

    发明人： Hitoshi Tone ,  Hisashi Miyamoto ,  Hiraki Ueda ,  Kazuyuki Nakagawa

    IPC分类号： C07D215/56 ,  C07D487/04 ,  A61K31/495 ,  C07D401/04

    CPC分类号： C07D487/04 ,  C07D215/56

    摘要： Novel 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or an alkyl having 1 to 2 carbon atoms, R.sup.2 is hydrogen atom or fluorine atom, and R.sup.3 is hydroxy, fluorine atom or an alkanoyloxy having 1 to 6 carbon atoms, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.

    摘要翻译： 新颖的1-取代的苯基-4-氧代喹啉-3-羧酸化合物，其结构式如下：其中R 1是氢原子或具有1至2个碳原子的烷基，R 2是氢原子或氟原子，R 3是羟基， 氟原子或具有1至6个碳原子的烷酰氧基及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及药物组合物，其包含作为活性成分的所述1-取代苯基-4 - 氧喹啉-3-羧酸化合物或其药学上可接受的盐与药学上可接受的稀释剂或载体混合。

    Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof
    2.
    发明授权
    Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof 失效
    抗菌剂1-取代苯基-4-氧代喹啉-3-羧酸化合物及其组合物

    公开(公告)号：US4684648A

    公开(公告)日：1987-08-04

    申请号：US770080

    申请日：1985-08-28

    申请人： Hitoshi Tone ,  Hisashi Miyamoto ,  Hiraki Ueda ,  Kazuyuki Nakagawa

    发明人： Hitoshi Tone ,  Hisashi Miyamoto ,  Hiraki Ueda ,  Kazuyuki Nakagawa

    IPC分类号： C07D215/56 ,  C07D487/04 ,  A61K31/40 ,  A61K31/47 ,  C07D401/14

    CPC分类号： C07D487/04 ,  C07D215/56

    摘要： Novel 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R is hydrogen atom or fluorine atom, R.degree. is hydroxy, fluorine atom or an alkanoyloxy having 1 to 6 carbon atoms, and X.sup.1 is hydrogen atom or fluorine atom, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.

    摘要翻译： 新颖的1-取代的苯基-4-氧代喹啉-3-羧酸化合物，其结构式如下：其中R是氢原子或氟原子，R是羟基，氟原子或具有1至6个碳原子的烷酰氧基，X1 所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及包含作为活性成分的所述1-取代苯基-4-氧代喹啉-3-酮的药物组合物， 羧酸化合物或其药学上可接受的盐与药学上可接受的稀释剂或载体混合。

    Benzoheterocyclic compounds
    6.
    发明授权
    Benzoheterocyclic compounds 失效
    苯并杂环化合物

    公开(公告)号：US5290934A

    公开(公告)日：1994-03-01

    申请号：US711273

    申请日：1991-06-04

    申请人： Hiraki Ueda ,  Hisashi Miyamoto ,  Hiroshi Yamashita ,  Hitoshi Tone

    发明人： Hiraki Ueda ,  Hisashi Miyamoto ,  Hiroshi Yamashita ,  Hitoshi Tone

    IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D409/04 ,  C07D487/04 ,  C07D491/04 ,  C07D498/06 ,  C07D215/283

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D409/04 ,  C07D487/04 ,  C07D491/04

    摘要： Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R.sup.2 is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be substituted, R.sup.3 is alkyl, R is H or alkyl, and X is halogen, and pharmaceutically acceptable salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient.

    摘要翻译： 具有下式的新型4-氧代喹啉-3-羧酸化合物：其中R 1是可以具有1至3个烷基和卤素取代基的环丙基; 可被1至3个烷氧基，卤素和OH取代基取代的苯基; 可被卤素，烷酰氧基或OH取代的烷基; 烯基; 或噻吩基，R 2为可被取代的5至9元饱和或不饱和杂环，R 3为烷基，R为H或烷基，X为卤素及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此 可用作抗微生物剂，以及含有所述化合物作为活性成分的药物组合物。

    Antimicrobial 1-thienyl-4-oxoquinoline-3-carboxylic acids
    10.
    发明授权
    Antimicrobial 1-thienyl-4-oxoquinoline-3-carboxylic acids 失效
    抗微生物1-噻吩基-4-氧代喹啉-3-羧酸

    公开(公告)号：US4786649A

    公开(公告)日：1988-11-22

    申请号：US929847

    申请日：1986-11-13

    申请人： Hiraki Ueda ,  Hisashi Miyamoto

    发明人： Hiraki Ueda ,  Hisashi Miyamoto

    IPC分类号： C07D333/00 ,  A61K31/47 ,  A61P31/04 ,  C07D401/14 ,  C07D409/14

    CPC分类号： C07D409/14

    摘要： Novel 1-thienyl-4-oxoquinoline-3-carboxylic acid compounds of the formula ##STR1## wherein R.sup.1 is an amino (lower) alkyl, R.sup.2 is thienyl, and X is a halogen atom, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-thienyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.

    摘要翻译： 新颖的下式的1-噻吩基-4-氧代喹啉-3-羧酸化合物，其中R 1是氨基（低级）烷基，R 2是噻吩基，X是卤素原子及其可药用盐，所述化合物 具有优异的抗微生物活性，因此可用作抗微生物剂，以及药物组合物，其包含作为活性成分的所述1-噻吩基-4-氧代喹啉-3-羧酸化合物或其药学上可接受的盐与药学上可接受的稀释剂或 载体