公开(公告)号：US4008237A

公开(公告)日：1977-02-15

申请号：US626001

申请日：1975-10-28

申请人： Hideo Agui ,  Iwao Nakatsuka ,  Toru Mitani ,  Mitsuo Nakashita ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

发明人： Hideo Agui ,  Iwao Nakatsuka ,  Toru Mitani ,  Mitsuo Nakashita ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

IPC分类号： C07D215/56 ,  C07D491/048

CPC分类号： C07D491/048

摘要： Novel antibacterial agents consisting of a 2,3,5,8-tetrahydro-5-alkoxy-8-oxofuro(2,3-g)quinoline-7-carboxylic acid of the formula: ##STR1## wherein R is C.sub.1 -C.sub.4 alkyl, a process for producing the derivatives and pharmaceutical compositions containing the same. The above-identified derivatives possess antibacterial activity against gram-negative bacteria at test concentration levels of about 0.0001 to 1.0 mg/cc.

摘要翻译： 新型抗菌剂由下列通式的2,3,5,8-四氢-5-烷氧基-8-氧代呋喃（2,3-g）喹啉-7-羧酸组成，其中R是C 1 -C 4烷基 ，制备衍生物的方法和含有该衍生物的药物组合物。 上述衍生物在约0.0001至1.0mg / cc的测试浓度水平下对革兰氏阴性细菌具有抗菌活性。

公开(公告)号：US3954775A

公开(公告)日：1976-05-04

申请号：US515753

申请日：1974-10-17

申请人： Hideo Agui ,  Toru Mitani ,  Mitsuo Nakashita ,  Eiichi Murayama ,  Kousaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

发明人： Hideo Agui ,  Toru Mitani ,  Mitsuo Nakashita ,  Eiichi Murayama ,  Kousaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

IPC分类号： C07D513/04

CPC分类号： C07D513/04

摘要： Thiazolo[5,4-f]quinoline-8-carboxylic acid derivatives having either the general formula (I): ##SPC1##wherein R.sub.1 is a lower alkyl group, a lower alkenyl group or a benzyl group; or the general formula (III-a): ##SPC2##Wherein R.sub.3 is a lower alkyl group and X is a halogen atom; and methods for the preparation thereof. The compounds of the general formula (I) are useful as antibacterial agents against gram-negative and gram-positive bacteria. The compounds of the general formula (III-a) are useful as antifungal agents against eumycetes and also as an intermediate in a preparation of the compounds of the general formula (I).

摘要翻译： 具有通式（I）的噻唑并[5,4-f]喹啉-8-羧酸衍生物：

公开(公告)号：US4054568A

公开(公告)日：1977-10-18

申请号：US661455

申请日：1976-02-25

申请人： Hideo Agui ,  Toru Mitani ,  Mitsuo Nakashita ,  Eiichi Murayama ,  Kousaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

发明人： Hideo Agui ,  Toru Mitani ,  Mitsuo Nakashita ,  Eiichi Murayama ,  Kousaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Yasuko Eda

IPC分类号： C07D513/04

CPC分类号： C07D513/04

摘要： Thiazolo[5,4-f]quinoline-8-carboxylic acid derivatives having either the general formula (I): ##STR1## wherein R.sub.1 is a lower alkyl group, a lower alkenyl group or a benzyl group; or the general formula (III-a): ##STR2## WHEREIN R.sub.3 is a lower alkyl group and X is a halogen atom; and methods for the preparation thereof. The compounds of the general formula (I) are useful as antibacterial agents against gram-negative and gram-positive bacteria. The compounds of the general formula (III-a) are useful as antifungal agents against eumycetes and also as an intermediate in a peparation of the compounds of the general formula (I).

摘要翻译： 具有通式（I）的噻唑并[5,4-f]喹啉-8-羧酸衍生物：其中R1是低级烷基，低级烯基或苄基; （III-a）：（III-a）其中R3为低级烷基，X为卤素原子; 及其制备方法。 通式（I）的化合物可用作抗革兰氏阴性细菌和革兰氏阳性细菌的抗菌剂。 通式（III-a）的化合物可用作抗真菌剂的抗真菌剂，也可用作通式（I）化合物的分离中的中间体。

公开(公告)号：US4226863A

公开(公告)日：1980-10-07

申请号：US937626

申请日：1978-08-25

申请人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

发明人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

IPC分类号： A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/04 ,  C07D501/06 ,  C07D501/20 ,  C07D501/24 ,  C07D501/28 ,  C07D501/32 ,  C07D501/34 ,  C07D501/36 ,  C07D501/40 ,  C07D501/44 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D501/60 ,  C07D519/06

CPC分类号： C07D501/57 ,  Y02P20/55

摘要： A cephalosporin of the formula (I): ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted; R is a phenyl group which may be unsubstituted or substituted, a thienyl group, a furyl group, a cyclohexadienyl group or a cyclohexenyl group; X is an acetoxy group, a pyridinium group which may be unsubstituted or substituted with a methyl or carbamoyl group, a group of the formula: ##STR2## in which R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group, or a group of the formula:--S--Hetin which Het is a heterocyclic ring containing 1 to 5 oxygen, nitrogen and sulfur atoms as a hetero atom, in which the heterocyclic ring system may be either polycyclic or 5- or 6-membered monocyclic and may be unsubstituted or substituted; and M is a hydrogen atom or a biologically active carboxyl-protecting group, or is an anionic charge only when X is a pyridinium group; and the pharamaceutically acceptable salts thereof, which are useful as antimicrobial agents and prepared by the reaction of a compound of the formula (II):HO--A--COOH (II)wherein A is as defined above, or a reactive derivative thereof, with a compound of the formula (III): ##STR3## wherein R, M and X are as defined above, or a derivative thereof.

摘要翻译： 式（I）的头孢菌素：其中A是含有至少一个氮原子作为杂原子的单环或多环杂芳环，其可以是未取代的或取代的; R是可以是未取代或取代的苯基，噻吩基，呋喃基，环己二烯基或环己烯基; X是乙酰氧基，可以是未取代的或被甲基或氨基甲酰基取代的吡啶鎓基，下式的基团：其中R 1和R 2可以相同或不同，各自为氢原子 或（C 1 -C 4）烷基或其中Het为含有1至5个氧，氮和硫原子作为杂原子的杂环的式-S-Het基团，其中杂环系统可以 可以是多环或5-或6-元单环，并且可以是未取代的或取代的; M为氢原子或生物活性羧基保护基，或仅当X为吡啶鎓基时为阴离子电荷; 和其药物学上可接受的盐，其可用作抗微生物剂并通过式（II）化合物：其中A如上定义的HO-A-COOH（II）或其反应性衍生物与 式（III）的化合物：其中R，M和X如上定义，或其衍生物。

公开(公告)号：US4302454A

公开(公告)日：1981-11-24

申请号：US105440

申请日：1979-12-19

申请人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

发明人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

IPC分类号： A61K31/545 ,  C07D501/36

CPC分类号： A61K31/545

摘要： A compound of the formula (I): ##STR1## wherein A is a monocyclic or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted with one or more substituents;R is a phenyl group which can be unsubstituted or substituted or a thienyl group;T is (1) a --CH.sub.2 --S--Het group, where Het is a tetrazolopyridazine ring, a triazolopyridazine ring, or a triazolopyridine ring, (2) a ##STR2## group where R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group, (3) a --CH.sub.2 N.sub.3 group or (4) a --CH.sub.2 S--D group in which D is a group selected from the group consisting of ##STR3## where m and n each is 0 to 3: with the proviso that (a) when the HO--A-- moiety is a ##STR4## group where B represents the non-metallic atoms necessary to complete a pyridine ring, a pyrimidine ring or a pyrazole ring, each of which may be unsubstituted or substituted, then T is the --CH.sub.2 SD group wherein D is as defined above, and(b) when T is the --CH.sub.2 N.sub.3 group, then R is a substituted phenyl groupand the non-toxic, pharmaceutically acceptable salts thereof, processes for preparing the same, and anti-microbial compositions containing the same.

摘要翻译： 式（I）的化合物：其中A是含有至少一个氮原子作为杂原子的单环或多环杂芳族环，其可以是未取代的或被一个或多个取代基取代; R是可以是未取代的或取代的苯基或噻吩基; T是（1）-CH 2 -S-Het基团，其中Het是四唑并哒嗪环，三唑并哒嗪环或三唑并吡啶环，（2）其中R 1和R 2可以相同或不同 各自为氢原子或（C1-C4）烷基，（3）-CH2N3基或（4）-CH2S-D基，其中D为选自下组的基团：图像 其中m和n各自为0至3，条件是（a）当HO-A-部分为“IMAGE”基团时，B表示完成所需的非金属原子 吡啶环，嘧啶环或吡唑环，其各自可以是未取代的或取代的，则T是-CH2SD基团，其中D如上所定义，和（b）当T是-CH 2 N 3基团时，R是 取代的苯基及其无毒的药学上可接受的盐，及其制备方法和含有它们的抗微生物组合物。

公开(公告)号：US4368198A

公开(公告)日：1983-01-11

申请号：US18212

申请日：1979-03-07

申请人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

发明人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

IPC分类号： A61K31/545 ,  C07D501/20

CPC分类号： A61K31/545

摘要： A compound of the formula (I): ##STR1## wherein A is a monocyclic or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted with one or more substituents;R is a phenyl group which can be unsubstituted or substituted or a thienyl group;T is (1) a --CH.sub.2 --S--Het group, where Het is a tetrazolopyridazine ring, a triazolopyridazine ring, or a triazolopyridine ring, (2) a ##STR2## group wherein R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group, (3) a --CH.sub.2 N.sub.3 group or (4) is --CH.sub.2 S--D group in which D is a group selected from the group consisting of ##STR3## where m and n each is 0 to 3: with the proviso that (a) when the HO--A-- moiety is a ##STR4## group where b represents the non-metallic atoms necessary to complete a pyridine ring, a pyrimidine ring or a pyrazole ring, each of which may be unsubstituted or substituted, then T is the --CH.sub.2 SD group wherein D is as defined above, and(b) when T is the --CH.sub.2 N.sub.3 group, then R is a substituted phenyl group and the non-toxic, pharmaceutically acceptable salts thereof, processes for preparing the same, and anti-microbial compositions containing the same.

摘要翻译： 式（I）的化合物：其中A是含有至少一个氮原子作为杂原子的单环或多环杂芳族环，其可以是未取代的或被一个或多个取代基取代; R是可以是未取代的或取代的苯基或噻吩基; T是（1）-CH 2 -S-Het基团，其中Het是四唑并哒嗪环，三唑并哒嗪环或三唑并吡啶环，（2）其中R 1和R 2可以相同或不同 各自为氢原子或（C1-C4）烷基，（3）-CH2N3基或（4）为-CH2S-D基，其中D为选自下组的基团：图像 > + TR 其中m和n各自为0至3：条件是（a）当HO-A-部分为“IMAGE”基团时，其中b表示完成吡啶环所必需的非金属原子 ，嘧啶环或吡唑环，其各自可以是未取代的或取代的，则T是-CH 2 SD基团，其中D如上所定义，和（b）当T是-CH 2 N 3基团时，则R是取代的苯基 组及其无毒的药学上可接受的盐，其制备方法和含有该组合物的抗微生物组合物。

公开(公告)号：US4165373A

公开(公告)日：1979-08-21

申请号：US773729

申请日：1977-03-02

申请人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

发明人： Hirotada Yamada ,  Takenari Nakagome ,  Toshiaki Komatsu

IPC分类号： A61K31/545 ,  C07D501/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D501/44

CPC分类号： A61K31/545

摘要： A compound of the formula (I): ##STR1## wherein A is a monocyclic or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted with one or more substituents;R is a phenyl group which can be unsubstituted or substituted or a thienyl group;T is (1) a -CH.sub.2 -S-Het group, where Het is a tetrazolopyridazine ring, a triazolopyridazine ring, or a triazolopyridine ring, (2) ##STR2## WHERE R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group, (3) a -CH.sub.2 N.sub.3 group or (4) a --CH.sub.2 S--D group in which D is a group selected from the group consisting of ##STR3## where m and n each is 0 to 3; with the proviso that (A) WHEN T is the --CH.sub.2 SD group wherein D is as defined above then the HO-A- moiety is a ##STR4## where B represents the non-metallic atoms necessary to complete a pyridine ring, a pyrimidine ring or a pyrazoline ring, each of which may be unsubstituted or subsituted, and(b) when T is the --CH.sub.2 N.sub.3 group, then R is a substituted phenyl groupAnd the non-toxic, pharmaceutically acceptable salts thereof, processes for preparing the same, and anti-microbial compositions containing the same.

摘要翻译： 式（I）的化合物：其中A是含有至少一个氮原子作为杂原子的单环或多环杂芳族环，其可以是未取代的或被一个或多个取代基取代; R是可以是未取代的或取代的苯基或噻吩基; T是（1）-CH2-S-Het基团，其中Het是四唑并哒嗪环，三唑并哒嗪环或三唑并吡啶环，（2）每个R 1和R 2可以相同或不同， 是氢原子或（C1-C4）烷基，（3）-CH2N3基团或（4）-CH2S-D基团，其中D是选自下组的基团：＆lt; IMAGE＆gt; + tr 其中m和n各自为0至3; 条件是（A）当T是-CH 2 SD基团，其中D如上所定义，则HO-A-部分是其中B表示完成吡啶环所需的非金属原子，嘧啶环 或吡唑啉环，其各自可以是未取代的或取代的，和（B）当T是-CH 2 N 3基团时，则R是取代的苯基，并且其非药物，药学上可接受的盐，其制备方法， 和含有该组合物的抗微生物组合物。

公开(公告)号：US4125611A

公开(公告)日：1978-11-14

申请号：US745749

申请日：1976-11-29

申请人： Hirotada Yamade ,  Takenari Nakagome ,  Toshiaki Komatsu

发明人： Hirotada Yamade ,  Takenari Nakagome ,  Toshiaki Komatsu

IPC分类号： A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/04 ,  C07D501/06 ,  C07D501/20 ,  C07D501/24 ,  C07D501/28 ,  C07D501/32 ,  C07D501/34 ,  C07D501/36 ,  C07D501/40 ,  C07D501/44 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57 ,  C07D501/60 ,  C07D519/06

CPC分类号： C07D501/57 ,  Y02P20/55

摘要： A cephalosporin of the formula (I): ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted; R is a phenyl group which may be unsubstituted or substituted, a thienyl group, a furyl group, a cyclohexadienyl group or a cyclohexenyl group; X is an acetoxy group, a pyridinium group which may be unsubstituted or substituted with a methyl or carbamoyl group, a group of the formula: ##STR2## in which R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or a (C.sub.1 - C.sub.4) alkyl group, or a group of the formula:-S-Hetin which Het is a heterocyclic ring containing 1 to 5 oxygen, nitrogen and sulfur atoms as a hetero atom, in which the heterocyclic ring system may be either polycyclic or 5- or 6-membered monocyclic and may be unsubstituted or substituted; and M is a hydrogen atom or a biologically active carboxyl-protecting group, or is an anionic charge only when X is a pyridinium group; and the pharmaceutically acceptable salts thereof, which are useful as antimicrobial agents and prepared by the reaction of a compound of the formula (II):ho--a--cooh (ii)wherein A is as defined above, or a reactive derivative thereof, with a compound of the formula (III): ##STR3## wherein R, M and X are as defined above, or a derivative thereof.

摘要翻译： 式（I）的头孢菌素：其中A是含有至少一个氮原子作为杂原子的单环或多环杂芳环，其可以是未取代的或取代的; R是可以是未取代或取代的苯基，噻吩基，呋喃基，环己二烯基或环己烯基; X是乙酰氧基，可以是未取代的或被甲基或氨基甲酰基取代的吡啶鎓基，下式的基团：其中R 1和R 2可以相同或不同，各自为氢原子 或（C 1 -C 4）烷基，或下式的基团：

公开(公告)号：US4146717A

公开(公告)日：1979-03-27

申请号：US454284

申请日：1974-03-25

申请人： Michihiro Yamamoto ,  Shigeaki Morooka ,  Masao Koshiba ,  Toshiaki Komatsu ,  Hiroshi Noguchi ,  Shigeho Inaba ,  Hisao Yamamoto

发明人： Michihiro Yamamoto ,  Shigeaki Morooka ,  Masao Koshiba ,  Toshiaki Komatsu ,  Hiroshi Noguchi ,  Shigeho Inaba ,  Hisao Yamamoto

IPC分类号： C07D239/82

CPC分类号： C07D239/82

摘要： Viral infections caused by viruses which belong to, e.g. Pox, Herpes, Adeno, Myxo, Paramyxo groups are controlled by administering an effective amount of quinazoline derivatives of the formula ##STR1## wherein R.sub.1 is cyclo, C.sub.3 -C.sub.8 alkyl, cyclo C.sub.3 -C.sub.8 alkyl C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy C.sub.1 -C.sub.4 alkyl, C.sub.2-C.sub.5 alkenyloxy C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkylthio C.sub.1 -C.sub.4 alkyl, polyhalo C.sub.1- C.sub.4 alkyl, a group of the formula ##STR2## (wherein m is an integer of 1 to 3; and R.sub.4 and R.sub.5 are individually C.sub.1 -C.sub.4 alkyl, and may form together with the adjacent nitrogen atom an unsubstituted or C.sub.1 -C.sub.4 alkyl substituted 3 to 6 membered saturated heterocyclic ring, which may contain another nitrogen or oxygen atom) or a group of the formula --C.sub.n H.sub.2n --R.sub.6 (wherein n is 0 or an integer of 1 to 3; and R.sub.6 is a phenyl group, a substituted phenyl group or an aromatic or non-aromatic 3 to 6 membered heterocyclic ring which contains one or two hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atom, and may be optionally substituted by one or two C.sub.1 -C.sub.4 alkyl, and further, those substituents on adjacent carbon atoms may be joined to form a benzene or cyclohexane ring); R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, trifluoromethyl or nitro; and R.sub.3 is phenyl, substituted phenyl, cyclo C.sub.3 -C.sub.6 alkyl, pyridyl, furyl, nitrofuryl, thienyl, nitrothienyl, methylthienyl or pyrimidinyl.

公开(公告)号：US08591375B2

公开(公告)日：2013-11-26

申请号：US12917272

申请日：2010-11-01

申请人： Atsushi Maruyama ,  Toshiaki Komatsu ,  Noriyuki Sudou ,  Masaaki Fusegi ,  Hiroyasu Furukawa

发明人： Atsushi Maruyama ,  Toshiaki Komatsu ,  Noriyuki Sudou ,  Masaaki Fusegi ,  Hiroyasu Furukawa

IPC分类号： F16H48/06 ,  F16H48/20 ,  F16H48/12 ,  F16D19/00

CPC分类号： F16H48/30 ,  F16D27/118 ,  F16D2300/12 ,  F16H48/08 ,  F16H48/24 ,  F16H2048/346

摘要： A clutch device is used in combination with a differential device. The clutch device is comprised of: a clutch housed in and rotatable with the differential device and axially movable from a disengaged state into an engaged state; a plunger slidably fit on the differential device and being axially movable from a first position where the plunger does not force the clutch to a second position where the plunger forces the clutch into the engaged state; an anti-rotated solenoid configured to drive the plunger; and a retainer supported by the differential device and in contact with both the plunger at the first position and the solenoid, whereby the plunger is barred from going beyond the first position and the solenoid is axially positioned in place.

摘要翻译： 离合器装置与差动装置结合使用。 离合器装置包括：离合器，其容纳在差速装置中并且可与该差速装置一起旋转并且可以从分离状态轴向移动到接合状态; 柱塞可滑动地装配在差速装置上并且可从第一位置轴向移动，其中柱塞不迫使离合器到第二位置，在第二位置，柱塞迫使离合器进入接合状态; 构造成驱动柱塞的反旋转螺线管; 以及由所述差速装置支撑并且与所述第一位置处的所述柱塞和所述螺线管接触的保持器，由此所述柱塞被禁止超过所述第一位置，并且所述螺线管被轴向定位就位。