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公开(公告)号：US07399877B2
公开(公告)日：2008-07-15
申请号：US10549630
申请日：2004-03-19
申请人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： C07F9/02
摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome
摘要翻译： 由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数， 符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性 的脂质体
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公开(公告)号：US5626751A
公开(公告)日：1997-05-06
申请号：US91714
申请日：1993-07-15
申请人： Hiroshi Kikuchi , Hitoshi Yamauchi , Kiyoto Yachi , Hiroshi Honda , Norio Suzuki , Akinori Hoshio , Takazo Hirose
发明人： Hiroshi Kikuchi , Hitoshi Yamauchi , Kiyoto Yachi , Hiroshi Honda , Norio Suzuki , Akinori Hoshio , Takazo Hirose
CPC分类号： B01D61/147 , A61K9/127 , B01D29/05 , B01D63/08 , B01D63/081 , Y10T156/1057
摘要： A filter unit comprises a metallic supporting plate possessed of stepped through holes opening with a larger diameter in one main surface and with a smaller diameter in the other main surface (wherein the diameter ratio of larger-diameter openings to smaller-diameter openings is desired to be in the range of 1:0.01 to 1:0.5) or a pressureproof supporting plate having in one surface thereof inclined liquid flow grooves arranged in a radial pattern and concentric circular liquid flow grooves adapted to intersect the radially arranged liquid flow grooves and a membrane filter disposed on the surface of the supporting plate containing larger-diameter openings or liquid flow grooves. This filter unit is ideally used for finely dividing and uniformly sizing suspended lipid particles assuming a definite average particle size and a specific particle size distribution. The high-pressure sizing apparatus and the method for production of suspended lipid particles utilize the filter unit constructed as described above and rely essentially for their operation on effecting fine division of lipid particles in the suspension by supplying the suspension of lipid particles from the membrane filter side under pressure and causing the suspension to pass through the membrane filter. Thus, they constitute themselves effective measures for pharmacological products and cosmetic products which are in need of lipid particles assuming a definite average particle size and a specific particle size distribution.
摘要翻译： 过滤器单元包括金属支撑板，其具有在一个主表面中具有较大直径的阶梯状通孔，并且在另一个主表面中具有较小直径（其中大直径开口与较小直径开口的直径比期望为 在1：0.01〜1：0.5的范围内）或者在一个表面上具有倾斜的液体流槽的径向图案的压力支撑板和适于与径向布置的液体流槽相交的同心圆形液体流动槽 过滤器设置在包含较大直径开口或液体流动槽的支撑板的表面上。 这种过滤器单元理想地用于假定具有确定的平均粒度和特定的粒度分布的悬浮脂质颗粒的细分和均匀的尺寸。 高压施胶装置和悬浮脂质颗粒的生产方法利用如上所述构造的过滤器单元，并且主要依靠它们的操作来通过从膜过滤器中提供脂质颗粒的悬浮液来实现悬浮液中脂质颗粒的精细分配 并使悬浮液通过膜过滤器。 因此，它们构成了需要脂质颗粒的药理产品和化妆品的有效措施，其具有确定的平均粒度和特定的粒度分布。
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公开(公告)号：US4960595A
公开(公告)日：1990-10-02
申请号：US222309
申请日：1987-11-16
CPC分类号： A61K9/1272 , Y10T428/249997
摘要： Lipid membrane structures containing a lactose monofatty acid ester or amide are disclosed. The lipid membrane structures are delivered preferentially to the liver parenchymal cells and are useful as carriers of drugs.
摘要翻译： 公开了含有乳糖单脂肪酸酯或酰胺的脂质膜结构。 脂质膜结构优先递送到肝实质细胞，并且可用作药物的载体。
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公开(公告)号：US20100166467A1
公开(公告)日：2010-07-01
申请号：US12278850
申请日：2007-03-28
申请人： Hiroshi Nakamura , Hitoshi Yamauchi , Koji Abe , Katsuhiko Sekine , Junji Tsuboi , Shinji Souma
发明人： Hiroshi Nakamura , Hitoshi Yamauchi , Koji Abe , Katsuhiko Sekine , Junji Tsuboi , Shinji Souma
IPC分类号： G03G15/095 , B29C39/12
CPC分类号： G03G15/0812 , G03G2215/0634
摘要： A developing blade (1) comprises a support member (2) having a coefficient of elasticity in the range of 0.5×104 to 4.0×104 kg/mm2 and a moment of inertia of area (Iz) in the range of 6.5E-04 to 1.2E-02, and a blade member (4) located on one surface of the support member (2) along one side edge (2A). The blade member (4) is made of a rubber material having a 25% modulus of no greater than 0.85 MPa, and has a moment of inertia of area (Iz) in the range of 8E-02 to 1.2E+01, and the blade member (4) has a warping of no greater than 10 mm in the longitudinal direction.
摘要翻译： 显影叶片（1）包括具有在0.5×10 4至4.0×10 4 kg / mm 2范围内的弹性系数的弹性系数的支撑构件（2），并且面积（Iz）的惯性矩在6.5E-04的范围内 至1.2E-02，以及沿着一个侧边缘（2A）位于支撑构件（2）的一个表面上的刀片构件（4）。 叶片构件（4）由25％模量不大于0.85MPa的橡胶材料制成，并且具有在8E-02至1.2E + 01范围内的面积（Iz）的惯性矩，并且 叶片构件（4）在纵向上具有不大于10mm的翘曲。
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15.发明授权公开(公告)号：US07725117B2
公开(公告)日：2010-05-25
申请号：US11647355
申请日：2006-12-29
摘要： In a network including a relay apparatus, a relay apparatus management part, a communication management server for controlling communication between communication terminals including a mobile communication terminal, and a messaging server, a communication support system that supports an establishment of connection between communication terminals includes a communication information acquiring part for, in a case where communication cannot be established between a mobile communication terminal and a partner-side terminal due to the congestion of communication, receiving terminal data thereof, a relay apparatus specifying part for specifying an alternative relay apparatus, and a message control part for causing a messaging server to perform processing of transmitting an inquiry message for inquiring about a possibility of movement to a coverage area of the alternative relay apparatus and processing of transmitting a content of a response message. The communication support system enables a rapid transition to a state in which communication between the mobile communication terminal and the partner-side terminal can be established, by allowing information to be exchanged between both the terminals, even in a case where the communication between the terminal and the relay apparatus is congested.
摘要翻译： 在包括中继设备，中继设备管理部分，用于控制包括移动通信终端的通信终端之间的通信和通信服务器的通信管理服务器的网络中，支持建立通信终端之间的连接的通信支持系统包括： 通信信息获取部，用于在由于通信拥塞而在移动通信终端与对方侧终端之间进行通信的接收的接收终端数据的情况下，用于指定备选中继装置的中继装置指定部，以及 消息控制部分，用于使消息传送服务器执行发送询问消息的处理，所述询问消息用于询问移动到替代中继装置的覆盖区域的可能性以及发送响应消息的内容的处理。 通信支持系统能够通过允许在两个终端之间交换信息来快速转换到可以建立移动通信终端和对方终端之间的通信的状态，即使在终端之间的通信 并且中继装置拥塞。
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公开(公告)号：US07531604B2
公开(公告)日：2009-05-12
申请号：US10529692
申请日：2003-09-30
申请人： Syunsuke Ohhashi , Kazuhiro Kubo , Chika Itoh , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
发明人： Syunsuke Ohhashi , Kazuhiro Kubo , Chika Itoh , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
CPC分类号： C08F8/40 , A61K8/14 , A61K8/8164 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K31/795 , A61Q19/00 , C08F220/28 , C08F222/06 , C08L53/00 , C08F222/04 , C08L2666/02
摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.
摘要翻译： 可用于脂质体改性的磷脂衍生物等，其是以式（1）表示的成分单元A，式（2A）表示的成分单元B和/或式 式（2B）和式（3）表示的成分单元C [R1和R2表示氢原子或甲基，条件是R1和R2不同时表示甲基; R3表示碳原子数为1〜3的二价烃基; AO表示碳原子数2〜4的氧化烯基， m表示加成的氧化烯基的平均摩尔数，为4≤m≤100的范围内的数; R4表示氢原子，碳原子数为1〜20的烃基或酰基， R5CO和R6CO表示碳原子数为8〜24的酰基， R 7表示碳原子数为2〜4的二价烃基; 并且X和Y表示氢原子，碱金属原子，铵或有机铵]，其中组分单元A相对于组分单元B和组分单元C的总量的摩尔比为7/3至3 / 7，组分单元C的含量相对于1摩尔共聚物为1〜4摩尔。
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公开(公告)号：US07440761B2
公开(公告)日：2008-10-21
申请号：US10896881
申请日：2004-07-23
IPC分类号： H04Q7/20
CPC分类号： H04B7/155
摘要： A wireless communication system including a wireless relay station storing a priority table in which identifiers of the communications that are relayed with higher priority are registered, a wireless relay device relaying communications specified by the communication identifiers registered in the priority table with higher priority than other communications, a stream server receiving communication start requests from any of the wireless terminals and sends to the wireless relay station communication identifiers specifying the communications that are about to be started, and requests registration in the priority table, and a wireless relay station registering the communication identifiers whose registration has been requested in the priority table, such that a proportion S/U of a sum S of consumption bandwidths of the communications specified by communication identifiers registered in the priority table to the available bandwidth U of the wireless network does not exceed a predetermined upper limit.
摘要翻译： 一种无线通信系统，包括存储优先级表的无线中继站，其中登记有以较高优先级中继的通信的标识符;无线中继设备，中继由优先级高于其他通信优先级的优先级表中登记的通信标识符指定的通信 接收来自任何无线终端的通信开始请求的流服务器，并向所述无线中继站发送指定要开始的通信的通信标识符，并请求在所述优先级表中的登记，以及登记所述通信标识符的无线中继站 在优先权表中请求其注册，使得在优先级表中登记的通信标识符指定的通信的消耗带宽的总和S与无线网络的可用带宽U的比例S / U不超过预定 上限
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公开(公告)号：US20080137587A1
公开(公告)日：2008-06-12
申请号：US12068352
申请日：2008-02-05
IPC分类号： H04B7/14
CPC分类号： H04B7/155
摘要： A wireless communication system including a wireless relay station storing a priority table in which identifiers of the communications that are relayed with higher priority are registered, a wireless relay device relaying communications specified by the communication identifiers registered in the priority table with higher priority than other communications, a stream server receiving communication start requests from any of the wireless terminals and sends to the wireless relay station communication identifiers specifying the communications that are about to be started, and requests registration in the priority table, and a wireless relay station registering the communication identifiers whose registration has been requested in the priority table, such that a proportion S/U of a sum S of consumption bandwidths of the communications specified by communication identifiers registered in the priority table to the available bandwidth U of the wireless network does not exceed a predetermined upper limit.
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19.发明申请公开(公告)号：US20070263818A1
公开(公告)日：2007-11-15
申请号：US11525053
申请日：2006-09-22
IPC分类号： H04M3/42
CPC分类号： H04L29/06027 , H04L47/10 , H04L47/14 , H04L47/2416 , H04L47/2433 , H04L65/1083 , H04L65/4076 , H04L65/4084 , H04L65/80
摘要： A relay apparatus for relaying communication between a plurality of wireless terminals and a wired network includes a priority data recording part for recording communication identification data and required bandwidth data, a priority control part for relaying, by priority, the communication recorded in the priority data recording part, a request receiving part for receiving communication identification data and multimedia type data, a selecting part for selecting a multimedia type to be relayed by priority, an updating part for additionally recording data that represents a bandwidth required for relaying a stream of the selected multimedia type and the communication identification data, and a responding part for transmitting a response. The selecting part selects the multimedia type so that a sum of bandwidths represented by the required bandwidth data does not exceed a predetermined upper limit value. With the above configuration, the relay apparatus can perform bandwidth control of communication to be relayed, considering the multimedia type included in the communication by a wireless terminal.
摘要翻译： 用于中继多个无线终端和有线网络之间的通信的中继装置包括用于记录通信识别数据和所需带宽数据的优先级数据记录部分，优先级优先控制记录在优先级数据记录中的通信的优先级控制部分 部分，用于接收通信识别数据和多媒体类型数据的请求接收部分，用于选择要优先中继的多媒体类型的选择部分，用于附加地记录表示所选择的多媒体流的中继所需的带宽的数据的更新部分 类型和通信识别数据，以及用于发送响应的响应部分。 选择部分选择多媒体类型，使得由所需带宽数据表示的带宽之和不超过预定的上限值。 利用上述配置，考虑到由无线终端进行的通信中包含的多媒体类型，中继装置可以进行要中继的通信的带宽控制。
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公开(公告)号：US08078187B2
公开(公告)日：2011-12-13
申请号：US12068352
申请日：2008-02-05
IPC分类号： H04W72/00
CPC分类号： H04B7/155
摘要： A wireless communication system including a wireless relay station storing a priority table in which identifiers of the communications that are relayed with higher priority are registered, a wireless relay device relaying communications specified by the communication identifiers registered in the priority table with higher priority than other communications, a stream server receiving communication start requests from any of the wireless terminals and sends to the wireless relay station communication identifiers specifying the communications that are about to be started, and requests registration in the priority table, and a wireless relay station registering the communication identifiers whose registration has been requested in the priority table, such that a proportion S/U of a sum S of consumption bandwidths of the communications specified by communication identifiers registered in the priority table to the available bandwidth U of the wireless network does not exceed a predetermined upper limit.
摘要翻译： 一种无线通信系统，包括存储优先级表的无线中继站，其中登记有以较高优先级中继的通信的标识符;无线中继设备，中继由优先级高于其他通信优先级的优先级表中登记的通信标识符指定的通信 接收来自任何无线终端的通信开始请求的流服务器，并向所述无线中继站发送指定要开始的通信的通信标识符，并请求在所述优先级表中的登记，以及登记所述通信标识符的无线中继站 在优先权表中请求其注册，使得在优先级表中登记的通信标识符指定的通信的消耗带宽的总和S与无线网络的可用带宽U的比例S / U不超过预定 上限
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