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公开(公告)号：US08729061B2
公开(公告)日：2014-05-20
申请号：US13681470
申请日：2012-11-20
发明人： David Banner , Wolfgang Haap , Bernd Kuhn , Thomas Luebbers , Jens-Uwe Peters , Tanja Schulz-Gasch
IPC分类号： A01N57/00 , A61K31/675 , A61K31/66 , A01N43/00 , A61K31/33
CPC分类号： C07D413/12 , C07D207/16 , C07D401/06 , C07D401/08 , C07D403/04 , C07D405/12
摘要： The invention relates to a compound of formula (I) wherein A and R1 to R7 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中A和R 1至R 7如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：US20130137687A1
公开(公告)日：2013-05-30
申请号：US13681470
申请日：2012-11-20
发明人： David Banner , Wolfgang Haap , Bernd Kuhn , Thomas Luebbers , Jens-Uwe Peters , Tanja Schulz-Gasch
IPC分类号： C07D413/12 , C07D403/04 , C07D401/06 , C07D207/16
CPC分类号： C07D413/12 , C07D207/16 , C07D401/06 , C07D401/08 , C07D403/04 , C07D405/12
摘要： The invention relates to a compound of formula (I) wherein A and R1 to R7 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中A和R 1至R 7如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：US20220135571A1
公开(公告)日：2022-05-05
申请号：US17558053
申请日：2021-12-21
发明人： Cosimo Dolente , Annick Goergler , Georg Jaeschke , Bernd Kuhn , Christa Ulrike Obst-Sander , Antonio Ricci , Daniel Rueher , Sandra Steiner , David Hewings , Yvonne Alice Nagel
IPC分类号： C07D487/04
摘要： The invention provides novel compounds as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20190308955A1
公开(公告)日：2019-10-10
申请号：US16449040
申请日：2019-06-21
发明人： Martin Duplessis , Georg Jaeschke , Bernd Kuhn , Kiel Lazarski , Yanke Liang , Yvonne Alice Nagel , Antonio Ricci , Daniel Rueher , Sandra Steiner
IPC分类号： C07D403/12 , C07D417/12 , C07D403/14 , C07D417/14 , A61K9/02 , A61K9/00 , A61K9/48 , A61K9/20
摘要： The present invention provides compounds which are selective allosteric inhibitors of T790M and C797S containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.
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公开(公告)号：US10035804B2
公开(公告)日：2018-07-31
申请号：US15479701
申请日：2017-04-05
发明人： Johannes Aebi , Kurt E. Amrein , Junli Chen , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Dongbo Li , Hans Peter Maerki , Rainer E. Martin , Alexander Mayweg , Xuefei Tan , Jun Wu , Jianhua Yu
IPC分类号： C07D487/10 , C07D471/10
CPC分类号： C07D487/10 , A61K9/2054 , A61K9/2059 , C07D471/10 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09790217B2
公开(公告)日：2017-10-17
申请号：US15498977
申请日：2017-04-27
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Dongbo Li , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan , Lisha Wang , Jun Wu
IPC分类号： C07D401/10 , C07D417/04 , C07D231/18 , C07D401/12 , C07D401/04 , C07D403/10 , C07D413/12 , C07D403/12 , C07D401/14 , C07D403/04
CPC分类号： C07D417/04 , C07D231/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2 and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20170226097A1
公开(公告)日：2017-08-10
申请号：US15498977
申请日：2017-04-27
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Dongbo Li , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan , Lisha Wang , Jun Wu
IPC分类号： C07D417/04 , C07D401/12 , C07D401/04 , C07D401/10 , C07D413/12 , C07D403/12 , C07D401/14 , C07D403/04 , C07D231/18 , C07D403/10
CPC分类号： C07D417/04 , C07D231/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2 and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20160075687A1
公开(公告)日：2016-03-17
申请号：US14947760
申请日：2015-11-20
发明人： Johannes Aebi , Kurt Amrein , Wenming Chen , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander Mayweg , Xuefei Tan , Lisha Wang , Mingwei Zhou
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, A, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09187429B2
公开(公告)日：2015-11-17
申请号：US13864889
申请日：2013-04-17
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Peter Mohr , Xuefei Tan
IPC分类号： C07D217/22 , C07D217/24 , A61K31/47 , C07D217/14 , C07D221/04 , C07D405/12 , C07D221/16
CPC分类号： C07D217/14 , C07D217/22 , C07D217/24 , C07D221/04 , C07D221/16 , C07D405/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，A和n如本文所述，包括化合物和 使用化合物的方法。
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公开(公告)号：US09133158B2
公开(公告)日：2015-09-15
申请号：US13688373
申请日：2012-11-29
发明人： Johannes Aebi , Kurt Amrein , Wenming Chen , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Alexander V. Mayweg , Peter Mohr , Xuefei Tan , Zhanguo Wang , Mingwei Zhou
IPC分类号： C07D471/04 , C07D217/22 , C07D405/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/107 , C07D491/113
CPC分类号： C07D401/04 , C07D217/22 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/107 , C07D491/113
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful, for example, as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，A1，A2，A3，A4，A5和n如本文所述，包括该化合物的组合物和使用 化合物。 该化合物可用作例如用于治疗或预防慢性肾脏疾病，充血性心力衰竭，高血压，原发性醛固酮增多症和库兴综合征的醛固酮合酶（CYP11B2或CYP11B1）抑制剂。
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