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![Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors](/abs-image/US/2023/03/21/US11608347B2/abs.jpg.150x150.jpg)
公开(公告)号：US11608347B2
公开(公告)日：2023-03-21
申请号：US16922427
申请日：2020-07-07
发明人： Ann Petersen , Joerg Benz , Uwe Grether , Benoit Hornsperger , Buelent Kocer , Bernd Kuhn , Hans Richter , Satoshi Tsuchiya , Yangcheng Qiu , Rui Chen
IPC分类号： C07D471/04 , C07D519/00
摘要： The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US11001555B2
公开(公告)日：2021-05-11
申请号：US16283595
申请日：2019-02-22
IPC分类号： C07D207/16 , C07D401/12 , C07K5/06 , C07K5/065 , C07K5/062 , C07D207/277 , C07K5/02 , A61P27/02 , A61P1/16 , A61P9/00 , A61P13/12 , A61P29/00 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X and R11 are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US10428108B2
公开(公告)日：2019-10-01
申请号：US15805521
申请日：2017-11-07
发明人： Benoit Hornsperger , Roberto Iacone , Eric A. Kitas , Hans P. Maerki , Michael Reutlinger , Peter Mohr
IPC分类号： C07D295/13 , C07K5/02 , C07C323/60 , C07C237/22 , A61K38/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20190185427A1
公开(公告)日：2019-06-20
申请号：US16283595
申请日：2019-02-22
IPC分类号： C07D207/16 , C07D401/12 , C07D413/12 , A61P9/00 , A61P29/00 , A61P1/16 , A61P13/12 , A61P27/02
CPC分类号： C07D207/16 , A61P1/16 , A61P9/00 , A61P13/12 , A61P27/02 , A61P29/00 , C07D207/277 , C07D401/12 , C07D413/12 , C07K5/0205 , C07K5/06026 , C07K5/06069 , C07K5/06078 , C07K5/06191
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X and R11 are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20150376180A1
公开(公告)日：2015-12-31
申请号：US14850052
申请日：2015-09-10
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Hans P. Maerki , Alexander V. Mayweg , Xuefei Tan
IPC分类号： C07D417/14 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R9, R10 and R11 are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 9，R 10和R 11如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：US10035804B2
公开(公告)日：2018-07-31
申请号：US15479701
申请日：2017-04-05
发明人： Johannes Aebi , Kurt E. Amrein , Junli Chen , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Dongbo Li , Hans Peter Maerki , Rainer E. Martin , Alexander Mayweg , Xuefei Tan , Jun Wu , Jianhua Yu
IPC分类号： C07D487/10 , C07D471/10
CPC分类号： C07D487/10 , A61K9/2054 , A61K9/2059 , C07D471/10 , C07D519/00
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R5, A1, A2, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09790217B2
公开(公告)日：2017-10-17
申请号：US15498977
申请日：2017-04-27
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Dongbo Li , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan , Lisha Wang , Jun Wu
IPC分类号： C07D401/10 , C07D417/04 , C07D231/18 , C07D401/12 , C07D401/04 , C07D403/10 , C07D413/12 , C07D403/12 , C07D401/14 , C07D403/04
CPC分类号： C07D417/04 , C07D231/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2 and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20170226097A1
公开(公告)日：2017-08-10
申请号：US15498977
申请日：2017-04-27
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Dongbo Li , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Xuefei Tan , Lisha Wang , Jun Wu
IPC分类号： C07D417/04 , C07D401/12 , C07D401/04 , C07D401/10 , C07D413/12 , C07D403/12 , C07D401/14 , C07D403/04 , C07D231/18 , C07D403/10
CPC分类号： C07D417/04 , C07D231/18 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2 and n are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20160075687A1
公开(公告)日：2016-03-17
申请号：US14947760
申请日：2015-11-20
发明人： Johannes Aebi , Kurt Amrein , Wenming Chen , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander Mayweg , Xuefei Tan , Lisha Wang , Mingwei Zhou
IPC分类号： C07D401/14
CPC分类号： C07D401/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, A, m, n and p are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US09187429B2
公开(公告)日：2015-11-17
申请号：US13864889
申请日：2013-04-17
发明人： Johannes Aebi , Kurt Amrein , Benoit Hornsperger , Bernd Kuhn , Yongfu Liu , Hans P. Maerki , Rainer E. Martin , Alexander V. Mayweg , Peter Mohr , Xuefei Tan
IPC分类号： C07D217/22 , C07D217/24 , A61K31/47 , C07D217/14 , C07D221/04 , C07D405/12 , C07D221/16
CPC分类号： C07D217/14 , C07D217/22 , C07D217/24 , C07D221/04 , C07D221/16 , C07D405/12
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，A和n如本文所述，包括化合物和 使用化合物的方法。
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