公开(公告)号：US20240383904A1

公开(公告)日：2024-11-21

申请号：US18632636

申请日：2024-04-11

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Julie Elisabeth Francoise BLAISING ,  Maude GIROUD ,  Uwe GRETHER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn Susannah O’HARA ,  Bernd PUELLMANN ,  Martin RITTER ,  Didier ROMBACH ,  Philipp Claudio SCHMID ,  Matthias Beat WITTWER

IPC: C07D487/04 ,  A61K9/20 ,  A61K9/48 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/424 ,  A61K31/427 ,  A61K31/433 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/537 ,  A61K31/5386 ,  A61K31/675 ,  C07D471/10 ,  C07D498/10 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides new MAGL inhibitors having the general formula (I) wherein the variables are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20240199587A1

公开(公告)日：2024-06-20

申请号：US18490967

申请日：2023-10-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Niels Kevin BRIAN ,  Kallie FRISTON ,  Maude GIROUD ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Camiel John LEAKE ,  Rainer E. MARTIN ,  David Friedrich Erhard NIPPA ,  Fionn Susannah O’HARA ,  Bernd PUELLMANN ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Philipp Claudio SCHMID ,  Shounan ZHANG

IPC: C07D403/14 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

Abstract: The invention provides new heterocyclic compounds having the general formula (I)




wherein A, B, X, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220275005A1

公开(公告)日：2022-09-01

申请号：US17737656

申请日：2022-05-05

Applicant: Hoffmann-La Roche Inc.

Inventor： Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O`HARA ,  Hans RICHTER

IPC: C07D498/04

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220213093A1

公开(公告)日：2022-07-07

申请号：US17552792

申请日：2021-12-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Fionn O'HARA ,  Hans RICHTER

IPC: C07D471/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20210094973A1

公开(公告)日：2021-04-01

申请号：US17027976

申请日：2020-09-22

Applicant: Hoffmann-La Roche Inc.

Inventor： Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER

IPC: C07D498/04 ,  A61K9/20 ,  A61K9/48

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L1, X, m, n and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220242876A1

公开(公告)日：2022-08-04

申请号：US17569749

申请日：2022-01-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Carsten KROLL ,  Flore REGGIANI ,  Miroslav KOSAR ,  Maurice BIEDERMANN ,  Bernd KUHN ,  Benoit HORNSPERGER ,  Uwe GRETHER ,  Fionn O'HARA ,  Hans RICHTER

IPC: C07D498/04 ,  C07D519/00 ,  C07D513/04

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1, R2, X, and Y are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220202963A1

公开(公告)日：2022-06-30

申请号：US17692632

申请日：2022-03-11

Applicant: Hoffmann-La Roche Inc. ,  ETH ZUERICH

Inventor： Ludovic COLLIN ,  Martin EDELMANN ,  Luca GOBBI ,  Uwe GRETHER ,  Thomas HARTUNG ,  Yingfang HE ,  Michael HONER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Linjing MU ,  Dieter MURI ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER

IPC: A61K51/04 ,  A61B6/03

Abstract: The invention provides new radiolabeled monoacylglycerol lipase (MAGL) inhibitors that are useful for medical imaging, such as positron-emission tomography (PET), single-photon emission computed tomography (SPECT) and/or autoradiography.

公开(公告)号：US20220106328A1

公开(公告)日：2022-04-07

申请号：US17552816

申请日：2021-12-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn O`HARA ,  Bernd PUELLMANN ,  Hans RICHTER ,  Martin RITTER

IPC: C07D498/04 ,  A61K9/20 ,  A61K9/48

Abstract: The invention provides new heterocyclic compounds having the general formulae (Ia) and (Ib) wherein A, B, and L are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20210387999A1

公开(公告)日：2021-12-16

申请号：US17325934

申请日：2021-05-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Bernd KUHN ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Hans RICHTER ,  Carsten KROLL ,  Katrin GROEBKE ZBINDEN ,  Fionn O'HARA ,  Didier ROMBACH ,  Marius Daniel Rinaldo LUTZ

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20210277020A1

公开(公告)日：2021-09-09

申请号：US17174000

申请日：2021-02-11

Applicant: Hoffmann-La Roche Inc.

Inventor： Lilli ANSELM ,  Joerg BENZ ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Dominik HEER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Fionn O`HARA ,  Hans RICHTER

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds, methods of using the compounds and methods of determining the monoacylglycerol lipase (MAGL) inhibitory activity of the compounds.