公开(公告)号：US20250099448A1

公开(公告)日：2025-03-27

申请号：US18832840

申请日：2023-01-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Julie Elisabeth Francoise BLAISING ,  Jason Jacques DENIZOT ,  Kallie FRISTON ,  Rudolf Liun Zaccaria GANZONI ,  Maude GIROUD ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Isabelle KAUFMANN ,  Bernd KUHN ,  Camiel John LEAKE ,  Jacopo MARGARINI ,  Rainer Eugen MARTIN ,  Fionn Susannah O'HARA ,  Bernd PUELLMANN ,  Martin RITTER ,  Didier ROMBACH ,  Valerie RUNTZ-SCHMITT ,  Philipp Claudio SCHMID ,  Matthias Beat WITTWER

IPC: A61K31/4439 ,  A61K31/4196 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/675 ,  C07D401/14 ,  C07D403/14 ,  C07D487/10

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A and R1 to R4 are as described heroin, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20240383904A1

公开(公告)日：2024-11-21

申请号：US18632636

申请日：2024-04-11

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Julie Elisabeth Francoise BLAISING ,  Maude GIROUD ,  Uwe GRETHER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn Susannah O’HARA ,  Bernd PUELLMANN ,  Martin RITTER ,  Didier ROMBACH ,  Philipp Claudio SCHMID ,  Matthias Beat WITTWER

IPC: C07D487/04 ,  A61K9/20 ,  A61K9/48 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/424 ,  A61K31/427 ,  A61K31/433 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/537 ,  A61K31/5386 ,  A61K31/675 ,  C07D471/10 ,  C07D498/10 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides new MAGL inhibitors having the general formula (I) wherein the variables are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20240199587A1

公开(公告)日：2024-06-20

申请号：US18490967

申请日：2023-10-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Machoud AMOUSSA ,  Joerg BENZ ,  Niels Kevin BRIAN ,  Kallie FRISTON ,  Maude GIROUD ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Camiel John LEAKE ,  Rainer E. MARTIN ,  David Friedrich Erhard NIPPA ,  Fionn Susannah O’HARA ,  Bernd PUELLMANN ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Philipp Claudio SCHMID ,  Shounan ZHANG

IPC: C07D403/14 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

CPC classification number: C07D403/14 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052

Abstract: The invention provides new heterocyclic compounds having the general formula (I)




wherein A, B, X, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.