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    COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING
    12.
    发明申请
    COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING 有权
    核苷酸序列的组合物和方法

    公开(公告)号：US20150225785A1

    公开(公告)日：2015-08-13

    申请号：US14695955

    申请日：2015-04-24

    Applicant: ILLUMINA, INC.

    Inventor： Chanfeng Zhao ,  Igor Kozlov ,  Melissa Won

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H19/04

    CPC classification number: C12Q1/6869 ,  C07H19/04 ,  C12P19/34 ,  C12Q1/6823 ,  C12Q2525/117 ,  C12Q2525/186 ,  C12Q2563/107

    Abstract: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group.

    Abstract translation: 本发明提供了含有连接标记如染料的可切割连接子的核苷和核苷酸分子。 本发明还提供含有可拆卸或不可移除的封闭基团的核苷和核苷酸分子。 本发明另外提供了使用含有可裂解连接子和/或封闭基团的核苷和核苷酸分子的方法。

    Compositions and methods for nucleotide sequencing
    13.
    发明授权
    Compositions and methods for nucleotide sequencing 有权
    核苷酸测序的组成和方法

    公开(公告)号：US09051612B2

    公开(公告)日：2015-06-09

    申请号：US14327872

    申请日：2014-07-10

    Applicant: Illumina, Inc.

    Inventor： Chanfeng Zhao ,  Igor Kozlov ,  Melissa Won

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H19/04

    CPC classification number: C12Q1/6869 ,  C07H19/04 ,  C12P19/34 ,  C12Q1/6823 ,  C12Q2525/117 ,  C12Q2525/186 ,  C12Q2563/107

    Abstract: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group.

    Abstract translation: 本发明提供了含有连接标记如染料的可切割连接子的核苷和核苷酸分子。 本发明还提供含有可拆卸或不可移除的封闭基团的核苷和核苷酸分子。 本发明另外提供了使用含有可裂解连接子和/或封闭基团的核苷和核苷酸分子的方法。

    Independently removable nucleic acid sequencing system and method
    15.
    发明授权
    Independently removable nucleic acid sequencing system and method 有权

    公开(公告)号：US11499191B2

    公开(公告)日：2022-11-15

    申请号：US16105262

    申请日：2018-08-20

    Applicant: Illumina, Inc.

    Inventor： Robert C. Kain ,  David L. Heiner ,  Chanfeng Zhao ,  Kevin Gunderson

    IPC: C12Q1/6874 ,  C12Q1/686 ,  C12Q1/6869

    Abstract: A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.

    COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING
    16.
    发明申请
    COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING 审中-公开
    核苷酸序列的组合物和方法

    公开(公告)号：US20170029883A1

    公开(公告)日：2017-02-02

    申请号：US15295728

    申请日：2016-10-17

    Applicant: Illumina, Inc.

    Inventor： Chanfeng Zhao ,  Igor Kozlov ,  Melissa Won

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6869 ,  C07H19/04 ,  C12P19/34 ,  C12Q1/6823 ,  C12Q2525/117 ,  C12Q2525/186 ,  C12Q2563/107

    Abstract: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either immovable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group.

    Abstract translation: 本发明提供了含有连接标记如染料的可切割连接子的核苷和核苷酸分子。 本发明还提供含有不可移动或不可移除的封闭基团的核苷和核苷酸分子。 本发明另外提供了使用含有可裂解连接子和/或封闭基团的核苷和核苷酸分子的方法。

    EFFICIENT BIOMOLECULE RECYCLING METHOD AND SYSTEM
    17.
    发明申请
    EFFICIENT BIOMOLECULE RECYCLING METHOD AND SYSTEM 有权
    有效的生物分子循环方法与系统

    公开(公告)号：US20160201126A1

    公开(公告)日：2016-07-14

    申请号：US15076962

    申请日：2016-03-22

    Applicant: Illumina, Inc.

    Inventor： Chanfeng Zhao

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q2563/107 ,  C12Q2565/629 ,  C12Q2565/30

    Abstract: A technique is disclosed for recapturing and recycling biomolecule reagents. The technique may be applied in a range of settings, including biopolymer synthesis, sequencing, and so forth. Biomolecule reagents such as nucleotides and oligonucleotides used to process nucleic acids, which may be marked with fluorescent tags, carry blocking agents, and so forth, are introduced to samples in a sample container. After the desired reaction occurs with some of the biomolecule reagents, such as some of the nucleotides or oligonucleotides, the effluent stream is processed to recapture unreacted biomolecule reagents. These may be separated from other reaction components, and recycled into the same or a different sample container. The recaptured biomolecule reagents may be mixed with additional biomolecule reagents prior to reintroduction to the same or different samples.

    Abstract translation: 公开了用于重新捕获和再循环生物分子试剂的技术。 该技术可以在一系列设置中应用，包括生物聚合物合成，测序等。 将用于处理核酸的核苷酸和寡核苷酸的生物分子试剂（可以用荧光标记进行标记，携带封闭剂等）引入到样品容器中的样品中。 在与一些生物分子试剂（例如一些核苷酸或寡核苷酸）发生所需反应之后，处理流出物流以再捕获未反应的生物分子试剂。 这些可以与其他反应组分分离，并且再循环到相同或不同的样品容器中。 在重新引入相同或不同的样品之前，重新捕获的生物分子试剂可与另外的生物分子试剂混合。

    COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING
    18.
    发明申请
    COMPOSITIONS AND METHODS FOR NUCLEOTIDE SEQUENCING 有权
    核苷酸序列的组合物和方法

    公开(公告)号：US20140370498A1

    公开(公告)日：2014-12-18

    申请号：US14327872

    申请日：2014-07-10

    Applicant: ILLUMINA, INC.

    Inventor： Chanfeng Zhao ,  Igor Kozlov ,  Melissa Won

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  C07H19/04 ,  C12P19/34 ,  C12Q1/6823 ,  C12Q2525/117 ,  C12Q2525/186 ,  C12Q2563/107

    Abstract: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group.

    Abstract translation: 本发明提供了含有连接标记如染料的可切割连接子的核苷和核苷酸分子。 本发明还提供含有可拆卸或不可移除的封闭基团的核苷和核苷酸分子。 本发明另外提供了使用含有可裂解连接子和/或封闭基团的核苷和核苷酸分子的方法。

    INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD
    19.
    发明申请
    INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD 有权
    独立的可除去的核酸序列系统和方法

    公开(公告)号：US20130288931A1

    公开(公告)日：2013-10-31

    申请号：US13653979

    申请日：2012-10-17

    Applicant: Illumina, Inc.

    Inventor： Robert C. Kain ,  David L. Heiner ,  Chanfeng Zhao ,  Kevin Gunderson

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q2565/501 ,  C12Q2537/143

    Abstract: A system for sequencing nucleic acids, that includes (a) a table having an arrangement of sites, including a site for receiving a first substrate, and a site for receiving a second substrate, the substrates each having an array for providing sequencing data for a plurality of different nucleic acids in parallel; (b) a plurality of stations configured to carry out manipulations in a sequencing procedure; and (c) a system control interface configured to direct relative movement between the table and the plurality of stations, and to direct different steps of the sequencing procedure to occur at the sites for receiving the different substrates, wherein the first substrate can be removed from the system independently of the second substrate such that the second substrate can be processed to obtain sequencing data independently of the first substrate.

    Abstract translation: 一种用于对核酸进行测序的系统，其包括（a）具有位置排列的表，包括用于接收第一底物的位点和用于接收第二底物的位点，所述基底各自具有阵列，用于提供用于 多个不同的核酸并行; （b）多个站，被配置为在排序过程中执行操作; 以及（c）系统控制接口，被配置为引导所述台与所述多个站之间的相对运动，并且引导所述排序程序的不同步骤在用于接收所述不同衬底的位置处发生，其中所述第一衬底可以从 所述系统独立于所述第二衬底，使得可以处理所述第二衬底以获得独立于所述第一衬底的测序数据。

    MICROFABRICATION METHODS FOR THE OPTIMAL PATTERNING OF SUBSTRATES
    20.
    发明申请
    MICROFABRICATION METHODS FOR THE OPTIMAL PATTERNING OF SUBSTRATES 有权
    用于基板的最佳方案的微晶化方法

    公开(公告)号：US20130096034A1

    公开(公告)日：2013-04-18

    申请号：US13707337

    申请日：2012-12-06

    Applicant: ILLUMINA, INC.

    Inventor： Michal Lebl ,  David L. Heiner ,  Chanfeng Zhao ,  David L. Barker

    IPC: C40B50/06

    CPC classification number: C40B50/06 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B50/14

    Abstract: A method of fabricating a microarray including the steps of: (a) contacting a substrate having wells with a reagent reactive with said substrate to produce a surface modification within said wells and a surface modification surrounding said wells; (b) polishing said substrate to produce a polished surface modification surrounding said wells, wherein said surface modification surrounding said wells is removed and said surface modification within said wells is retained, and (c) depositing a biopolymer onto said substrate, wherein different affinities of said surface modification within said wells and said polished surface facilitate localization of said biopolymer within said wells.

    Abstract translation: 一种制造微阵列的方法，包括以下步骤：（a）使具有孔的底物与具有与所述底物反应的试剂接触以在所述孔内产生表面改性和围绕所述孔的表面改性; （b）抛光所述基底以产生围绕所述孔的抛光表面修饰，其中去除围绕所述孔的所述表面改性并保留所述孔内的所述表面改性，和（c）将生物聚合物沉积到所述基底上，其中不同的亲和力 所述孔和所述抛光表面内的所述表面改性促进所述生物聚合物在所述孔内的定位。

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