Patent search ap:("ILLUMINA Page INC.") AND inv:"Michal Lebl"

1.

发明授权
Microfabrication methods for the optimal patterning of substrates 有权

公开(公告)号：US09677194B2

公开(公告)日：2017-06-13

申请号：US13707337

申请日：2012-12-06

Applicant: ILLUMINA, INC.

Inventor： Michal Lebl , David L. Heiner , Chanfeng Zhao , David L. Barker

IPC: C40B50/06 , B01J19/00 , C40B40/06 , C40B50/14

CPC classification number: C40B50/06 , B01J19/0046 , B01J2219/00317 , B01J2219/00497 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B50/14

Abstract: A method of fabricating a microarray including the steps of: (a) contacting a substrate having wells with a reagent reactive with said substrate to produce a surface modification within said wells and a surface modification surrounding said wells; (b) polishing said substrate to produce a polished surface modification surrounding said wells, wherein said surface modification surrounding said wells is removed and said surface modification within said wells is retained, and (c) depositing a biopolymer onto said substrate, wherein different affinities of said surface modification within said wells and said polished surface facilitate localization of said biopolymer within said wells.

2.

发明授权
Microvessels, microparticles, and methods of manufacturing and using the same 有权
Title translation: 微血管，微粒及其制造方法和使用方法

公开(公告)号：US09023638B2

公开(公告)日：2015-05-05

申请号：US13969050

申请日：2013-08-16

Applicant: Illumina, Inc.

Inventor： John A. Moon , M. Shane Bowen , Ryan C. Smith , Michel Perbost , Michal Lebl , Steven H. Modiano

IPC: G01N33/50 , B01J19/00 , B01L3/00 , C40B20/04 , G01N21/25 , G01N21/64 , G01N21/01 , G01N35/00

CPC classification number: G01N33/50 , B01J19/0046 , B01J2219/00306 , B01J2219/00511 , B01J2219/0052 , B01J2219/00524 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00673 , B01J2219/00702 , B01J2219/0072 , B01L3/502761 , B01L3/5082 , B01L3/50857 , B01L3/5088 , B01L3/545 , C40B20/04 , G01N21/01 , G01N21/253 , G01N21/6452 , G01N35/00732

Abstract: A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical substance in the reservoir core from an ambient environment surrounding the microbody. The microbody includes a transparent material that at least partially surrounds the reservoir core and facilitates detection of an optical characteristic of the substance within the reservoir core. The microbody of each microvessel includes an identifiable code that distinguishes individual microvessels of the plurality of encoded microvessels from each other. The plurality of isolated microvessels also includes a plurality of compartments each configured to separate individual microvessels of the plurality of encoded microvessels from each other.

Abstract translation: 多个分离的微血管包括多个编码的微血管，每个具有微体和储存器芯。微体构造成将储层芯中的生物或化学物质与围绕微体的周围环境分离。微体包括透明材料，其至少部分地围绕储存器芯并且便于检测储存器芯内的物质的光学特性。每个微血管的微体包括将多个编码微血管的各个微血管彼此区分开的可识别代码。多个分离的微血管还包括多个隔室，每个隔室被配置为将多个编码微血管中的各个微血管彼此分开。

3.

发明申请
SYSTEM OR DEVICE FOR BIOCHEMICAL ANALYSIS HAVING AT LEAST ONE ELECTROOSMOTIC PUMP 有权
Title translation: 用于生物化学分析的系统或装置，具有至少一个电动泵

公开(公告)号：US20140080205A1

公开(公告)日：2014-03-20

申请号：US14085122

申请日：2013-11-20

Applicant: THE ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , ILLUMINA, INC.

Inventor： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder

IPC: F04B37/10

CPC classification number: F04B37/10 , F04B19/00 , Y10T436/2575

Abstract: An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.

Abstract translation: 提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

4.

发明申请
MICROVESSELS, MICROPARTICLES, AND METHODS OF MANUFACTURING AND USING THE SAME 有权
Title translation: MICROVESSELS，MICROPARTICLES，AND METHODS OF MANUFACTURING AND USING THE SAME

公开(公告)号：US20140100123A1

公开(公告)日：2014-04-10

申请号：US13969050

申请日：2013-08-16

Applicant: Illumina, Inc.

Inventor： John A. Moon , M. Shane Bowen , Ryan C. Smith , Michel Perbost , Michal Lebl , Steven H. Modiano

IPC: G01N33/50

CPC classification number: G01N33/50 , B01J19/0046 , B01J2219/00306 , B01J2219/00511 , B01J2219/0052 , B01J2219/00524 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00673 , B01J2219/00702 , B01J2219/0072 , B01L3/502761 , B01L3/5082 , B01L3/50857 , B01L3/5088 , B01L3/545 , C40B20/04 , G01N21/01 , G01N21/253 , G01N21/6452 , G01N35/00732

Abstract: A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical substance in the reservoir core from an ambient environment surrounding the microbody. The microbody includes a transparent material that at least partially surrounds the reservoir core and facilitates detection of an optical characteristic of the substance within the reservoir core. The microbody of each microvessel includes an identifiable code that distinguishes individual microvessels of the plurality of encoded microvessels from each other. The plurality of isolated microvessels also includes a plurality of compartments each configured to separate individual microvessels of the plurality of encoded microvessels from each other.

Abstract translation: 多个分离的微血管包括多个编码的微血管，每个具有微体和储存器芯。微体构造成将储层芯中的生物或化学物质与围绕微体的周围环境分离。微体包括透明材料，其至少部分地围绕储存器芯并且便于检测储存器芯内的物质的光学特性。每个微血管的微体包括将多个编码微血管的各个微血管彼此区分开的可识别代码。多个分离的微血管还包括多个隔室，每个隔室被配置为将多个编码微血管中的各个微血管彼此分开。

5.

发明申请
MICROFABRICATION METHODS FOR THE OPTIMAL PATTERNING OF SUBSTRATES 有权
Title translation: 用于基板的最佳方案的微晶化方法

公开(公告)号：US20130096034A1

公开(公告)日：2013-04-18

申请号：US13707337

申请日：2012-12-06

Applicant: ILLUMINA, INC.

Inventor： Michal Lebl , David L. Heiner , Chanfeng Zhao , David L. Barker

IPC: C40B50/06

CPC classification number: C40B50/06 , B01J19/0046 , B01J2219/00317 , B01J2219/00497 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B50/14

Abstract: A method of fabricating a microarray including the steps of: (a) contacting a substrate having wells with a reagent reactive with said substrate to produce a surface modification within said wells and a surface modification surrounding said wells; (b) polishing said substrate to produce a polished surface modification surrounding said wells, wherein said surface modification surrounding said wells is removed and said surface modification within said wells is retained, and (c) depositing a biopolymer onto said substrate, wherein different affinities of said surface modification within said wells and said polished surface facilitate localization of said biopolymer within said wells.

Abstract translation: 一种制造微阵列的方法，包括以下步骤：（a）使具有孔的底物与具有与所述底物反应的试剂接触以在所述孔内产生表面改性和围绕所述孔的表面改性; （b）抛光所述基底以产生围绕所述孔的抛光表面修饰，其中去除围绕所述孔的所述表面改性并保留所述孔内的所述表面改性，和（c）将生物聚合物沉积到所述基底上，其中不同的亲和力所述孔和所述抛光表面内的所述表面改性促进所述生物聚合物在所述孔内的定位。

6.

发明授权
System or device for biochemical analysis having at least one electroosmotic pump 有权
Title translation: 用于生化分析的系统或装置具有至少一个电渗泵

公开(公告)号：US08753584B2

公开(公告)日：2014-06-17

申请号：US14085122

申请日：2013-11-20

Applicant: Illumina, Inc. , The Arizona Board of Regents for and on Behalf of Arizona State University

Inventor： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder

IPC: B01L3/00

CPC classification number: F04B37/10 , F04B19/00 , Y10T436/2575

Abstract: An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.

Abstract translation: 提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。