公开(公告)号：US11578094B2

公开(公告)日：2023-02-14

申请号：US17106963

申请日：2020-11-30

Applicant: ILLUMINA, INC. ,  ILLUMINA SINGAPORE PTE. LTD.

Inventor： Jeffrey Mandell ,  Silvia Gravina ,  Sergio Peisajovich ,  Kaitlin Pugliese ,  Yin Nah Teo ,  Xiangyuan Yang ,  Maria Candelaria Rogert Bacigalupo

IPC: C12Q1/68 ,  C07H21/00 ,  C12Q1/6869 ,  C40B70/00

Abstract: Provided is a method including detecting an incorporation of a labelled nucleotide into a nascent polynucleotide strand complementary to a template polynucleotide strand by a polymerase, wherein the polymerase is tethered to a solid support conductive channel by a tether and the labelled nucleotides is a compound of Formula I: