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公开(公告)号：US10905741B2
公开(公告)日：2021-02-02
申请号：US16714098
申请日：2019-12-13
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US10420816B1
公开(公告)日：2019-09-24
申请号：US16419818
申请日：2019-05-22
Applicant: IMMATICS BIOTECHNOLOGIES GMBH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A method of treating a patient who has gastric cancer, gastrointestinal cancer, colorectal cancer, pancreatic cancer, lung cancer, and/or renal cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has gastric cancer, gastrointestinal cancer, colorectal cancer, pancreatic cancer, lung cancer, and/or renal cancer. A method of treating a patient who has cancer includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the cancer.
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公开(公告)号：US09993523B2
公开(公告)日：2018-06-12
申请号：US15639310
申请日：2017-06-30
Applicant: IMMATICS BIOTECHNOLOGIES GMBH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
Abstract: A method of treating a patient who has gastric cancer, gastrointestinal cancer, colorectal cancer, pancreatic cancer, lung cancer, and/or renal cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated T cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the T cells bind to the peptide in a complex with an MHC class I molecule, and the composition is for treating the patient who has gastric cancer, gastrointestinal cancer, colorectal cancer, pancreatic cancer, lung cancer, and/or renal cancer. A method of treating a patient who has cancer includes administering to said patient a composition comprising a peptide in the form of a pharmaceutically acceptable salt, thereby inducing a T-cell response to the cancer.
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公开(公告)号：US11957730B2
公开(公告)日：2024-04-16
申请号：US17383855
申请日：2021-07-23
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61P35/00 , C07K7/06 , G01N33/505 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , C07K2319/00
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US11883462B2
公开(公告)日：2024-01-30
申请号：US17320782
申请日：2021-05-14
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61P35/00 , C07K7/06 , G01N33/505 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , C07K2319/00
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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Patent Agency Ranking
公开(公告)号：US10898546B2
公开(公告)日：2021-01-26
申请号：US16894186
申请日：2020-06-05
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US10434136B2
公开(公告)日：2019-10-08
申请号：US13931413
申请日：2013-06-28
Applicant: Immatics Biotechnologies GmbH
Inventor： Hans-Georg Rammensee , Stefan Stevanovic , Cecile Gouttefangeas , Toni Weinschenk , Peter Lewandrowski
IPC: A61K38/10 , A61K39/00 , C07K14/47 , C07K14/705 , C07K7/08 , C07K16/18 , C07H21/00 , C12N15/86 , C12N15/10
Abstract: The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention specifically relates to three novel peptide sequences and variants thereof derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：US12064465B2
公开(公告)日：2024-08-20
申请号：US17491742
申请日：2021-10-01
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61P35/00 , C07K7/06 , G01N33/505 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , C07K2319/00
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US11975042B2
公开(公告)日：2024-05-07
申请号：US17383892
申请日：2021-07-23
Applicant: Immatics Biotechnologies GmbH
Inventor： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
CPC classification number: A61K38/1709 , A61K39/0011 , A61P35/00 , C07K7/06 , G01N33/505 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , C07K2319/00
Abstract: A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer includes administering to a subject in need thereof the pharmaceutical composition. A kit includes a container that contains the pharmaceutical composition. A method of producing an antibody or a fragment thereof against a peptide or a MHC/peptide complex. A method for detecting a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a radioisotope and detecting a signal from the radioisotope in the subject. A method for treating a diseased tissue includes administering to a subject in need thereof an antibody or a fragment thereof conjugated to a toxin.
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公开(公告)号：US11957729B2
公开(公告)日：2024-04-16
申请号：US16510442
申请日：2019-07-12
Applicant: Immatics Biotechnologies GmbH
Inventor： Hans Georg Rammensee , Stefan Stevanovic , Cecile Gouttefangeas , Toni Weinschenk , Peter Lewandrowski
IPC: A61K39/00 , A61K38/10 , C07K7/08 , C07K14/47 , C07K14/705 , C07K16/18 , C07H21/00 , C12N5/0783 , C12N5/09 , C12N15/10 , C12N15/86
CPC classification number: A61K38/10 , A61K39/00115 , C07K7/08 , C07K14/4747 , C07K14/4748 , C07K14/7056 , C07K16/18 , C07H21/00 , C12N15/10 , C12N15/86
Abstract: The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention specifically relates to three novel peptide sequences and variants thereof derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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