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公开(公告)号：US08071770B2
公开(公告)日：2011-12-06
申请号：US12084917
申请日：2006-11-14
IPC分类号： C07D211/00 , C07D401/00
CPC分类号： C07D487/10 , C07D471/10 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2和R6如本文所述），其是CGRP受体的拮抗剂 并且其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20090325991A1
公开(公告)日：2009-12-31
申请号：US12085131
申请日：2006-11-14
IPC分类号： A61K31/437 , C07D471/04 , A61P25/00
CPC分类号： C07D471/20 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2, J and K are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2，J和K如本文所述） CGRP受体，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08071771B2
公开(公告)日：2011-12-06
申请号：US12085005
申请日：2006-11-14
IPC分类号： C07D211/00 , C07D401/00
CPC分类号： C07D487/10 , C07D471/10
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2和R6如本文所述），其是CGRP受体的拮抗剂 并且其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20090239870A1
公开(公告)日：2009-09-24
申请号：US12084917
申请日：2006-11-14
IPC分类号： A61K31/502 , C07D471/10 , A61K31/4747 , A61K31/496 , C07D487/10
CPC分类号： C07D487/10 , C07D471/10 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2和R6如本文所述），其是CGRP受体的拮抗剂 并且其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20090176757A1
公开(公告)日：2009-07-09
申请号：US12085005
申请日：2006-11-14
IPC分类号： A61K31/554 , A61K31/553 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/496 , A61K31/4747
CPC分类号： C07D487/10 , C07D471/10
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2和R6如本文所述），其是CGRP受体的拮抗剂 并且其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080214511A1
公开(公告)日：2008-09-04
申请号：US11662246
申请日：2005-09-06
申请人： Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
发明人： Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
IPC分类号： A61K31/437 , C07D471/06 , C07D487/06 , A61P25/00 , A61K31/55 , A61K31/53 , A61K31/4985 , A61K31/616 , A61K31/5415
CPC分类号： C07D519/00 , C07D209/96 , C07D471/06 , C07D471/16 , C07D487/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A 1，A 2，B 1，B 2， B，S 4，B 4，D 1，D 2，J，K，T， U，V，W，X，Y，Z，R 4，R 5a，R 5b，R 5c， >，m和n在本文中定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080318927A1
公开(公告)日：2008-12-25
申请号：US12214460
申请日：2008-06-19
申请人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
发明人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
IPC分类号： A61K31/551 , A61K31/454 , C07D401/12 , A61K31/541 , A61P25/06 , A61K31/501 , A61K31/496 , C07D417/12 , C07D471/04
CPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/20 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A2, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A2，A4，m，n，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf，RPG和Y如本文所述） CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07625901B2
公开(公告)日：2009-12-01
申请号：US12214460
申请日：2008-06-19
申请人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
发明人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
IPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D519/00 , C07D471/20 , A61K31/499 , A61K31/4965 , A61K31/438 , A61K31/4439 , A61K31/4188 , A61P25/06
CPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/20 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，m，n，J，Q，R4，Ea，Eb，Ec，R6，R7，Re，Rf，RPG和Y如本文所述） CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07629338B2
公开(公告)日：2009-12-08
申请号：US11800626
申请日：2007-05-07
申请人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
发明人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
IPC分类号： C07D401/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D519/00 , A61K31/403 , A61K31/407 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/438 , A61P25/06
CPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/20 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20070265225A1
公开(公告)日：2007-11-15
申请号：US11800626
申请日：2007-05-07
申请人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
发明人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
IPC分类号： C07F7/02 , A61K31/695 , A61K31/55
CPC分类号： C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/20 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A 1，A 2，A 3，A 4，m， n，J，Q，R 4，O，S，O，B， 6，R 7，R e，R f，R PG和Y如上所述 在本文中），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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